Search Results - "Choveau, Frank"

Clustering and Functional Coupling of Diverse Ion Channels and Signaling Proteins Revealed by Super-resolution STORM Microscopy in Neurons by Zhang, Jie, Carver, Chase M., Choveau, Frank S., Shapiro, Mark S.

“…The fidelity of neuronal signaling requires organization of signaling molecules into macromolecular complexes, whose components are in intimate proximity. The…”
Get full text

Phosphatidylinositol 4,5-bisphosphate (PIP2) regulates KCNQ3 K+ channels by interacting with four cytoplasmic channel domains by Choveau, Frank S., De la Rosa, Victor, Bierbower, Sonya M., Hernandez, Ciria C., Shapiro, Mark S.

“…Phosphatidylinositol 4,5-bisphosphate (PIP2) in the plasma membrane regulates the function of many ion channels, including M-type (potassium voltage-gated…”
Get full text

Augmentation of M-type (KCNQ) potassium channels as a novel strategy to reduce stroke-induced brain injury by Bierbower, Sonya M, Choveau, Frank S, Lechleiter, James D, Shapiro, Mark S

“…Cerebral ischemic stroke is a worldwide cause of mortality/morbidity and thus an important focus of research to decrease the severity of brain injury…”
Get full text

Antagonistic Effect of a Cytoplasmic Domain on the Basal Activity of Polymodal Potassium Channels by Soussia, Ismail Ben, Choveau, Frank S, Blin, Sandy, Kim, Eun-Jin, Feliciangeli, Sylvain, Chatelain, Franck C, Kang, Dawon, Bichet, Delphine, Lesage, Florian

“…TREK/TRAAK channels are polymodal K channels that convert very diverse stimuli, including bioactive lipids, mechanical stretch and temperature, into electrical…”
Get full text

Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels by Choveau, Frank S, Ben Soussia, Ismail, Bichet, Delphine, Franck, Chatelain C., Feliciangeli, Sylvain, Lesage, Florian

“…Inhibitory potassium channels of the TREK1/TRAAK family are integrators of multiple stimuli, including temperature, membrane stretch, polyunsaturated fatty…”
Get full text

The Role of the Carboxyl Terminus Helix C-D Linker in Regulating KCNQ3 K+ Current Amplitudes by Controlling Channel Trafficking by Choveau, Frank S, Zhang, Jie, Bierbower, Sonya M, Sharma, Ramaswamy, Shapiro, Mark S

“…In the central and peripheral nervous system, the assembly of KCNQ3 with KCNQ2 as mostly heteromers, but also homomers, underlies "M-type" currents, a…”
Get full text

Corrigendum: Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels by Choveau, Frank S., Ben Soussia, Ismail, Bichet, Delphine, Chatelain, Franck C., Feliciangeli, Sylvain, Lesage, Florian

Get full text

Pore Helix-S6 Interactions Are Critical in Governing Current Amplitudes of KCNQ3 K+ Channels by Choveau, Frank S., Bierbower, Sonya M., Shapiro, Mark S.

“…Two mechanisms have been postulated to underlie KCNQ3 homomeric current amplitudes, which are small compared with those of KCNQ4 homomers and KCNQ2/Q3…”
Get full text

Pore Determinants of KCNQ3 K+ Current Expression by Choveau, Frank S., Hernandez, Ciria C., Bierbower, Sonya M., Shapiro, Mark S.

“…KCNQ3 homomeric channels yield very small macroscopic currents compared with other KCNQ channels or KCNQ2/3 heteromers. Two disparate regions of the…”
Get full text

Astemizole Sensitizes Adrenocortical Carcinoma Cells to Doxorubicin by Inhibiting Patched Drug Efflux Activity by Hasanovic, Anida, Simsir, Méliné, Choveau, Frank S., Lalli, Enzo, Mus-Veteau, Isabelle

“…Adrenocortical carcinoma (ACC) presents a high risk of relapse and metastases with outcomes not improving despite extensive research and new targeted…”
Get full text

The S4-S5 Linker of KCNQ1 Channels Forms a Structural Scaffold with the S6 Segment Controlling Gate Closure by Labro, Alain J., Boulet, Inge R., Choveau, Frank S., Mayeur, Evy, Bruyns, Tine, Loussouarn, Gildas, Raes, Adam L., Snyders, Dirk J.

“…In vivo, KCNQ1 α-subunits associate with the β-subunit KCNE1 to generate the slowly activating cardiac potassium current (IKs). Structurally, they share their…”
Get full text

Kv7.1 (KCNQ1) properties and channelopathies by Peroz, David, Rodriguez, Nicolas, Choveau, Frank, Baró, Isabelle, Mérot, Jean, Loussouarn, Gildas

“…KCNQ1 is the pore-forming subunit of a channel complex whose expression and function have been rather well characterized in the heart. Almost 300 mutations of…”
Get full text

KCNQ1 Channels Voltage Dependence through a Voltage-dependent Binding of the S4-S5 Linker to the Pore Domain by Choveau, Frank S., Rodriguez, Nicolas, Ali, Fayal Abderemane, Labro, Alain J., Rose, Thierry, Dahimène, Shehrazade, Boudin, Hélène, Le Hénaff, Carole, Escande, Denis, Snyders, Dirk J., Charpentier, Flavien, Mérot, Jean, Baró, Isabelle, Loussouarn, Gildas

“…Voltage-dependent potassium (Kv) channels are tetramers of six transmembrane domain (S1–S6) proteins. Crystallographic data demonstrate that the tetrameric…”
Get full text

KCNE1–KCNQ1 osmoregulation by interaction of phosphatidylinositol‐4,5‐bisphosphate with Mg2+ and polyamines by Piron, Julien, Choveau, Frank S., Amarouch, Mohammed Yassine, Rodriguez, Nicolas, Charpentier, Flavien, Mérot, Jean, Baró, Isabelle, Loussouarn, Gildas

“…KCNQ1 osmosensitivity is of physiological and pathophysiological relevance in epithelial and cardiac cells, but the mechanism involved remains elusive. In…”
Get full text

Regions of KCNQ K(+) channels controlling functional expression by Choveau, Frank S, Shapiro, Mark S

“…KCNQ1-5 α-subunits assemble to form K(+) channels that play critical roles in the function of numerous tissues. The channels are tetramers of subunits…”
Get full text

Transfer of Rolf S3-S4 Linker to hERG Eliminates Activation Gating but Spares Inactivation by Choveau, Frank S., El Harchi, Aziza, Rodriguez, Nicolas, Louérat-Oriou, Bénédicte, Baró, Isabelle, Demolombe, Sophie, Charpentier, Flavien, Loussouarn, Gildas

“…Studies in Shaker, a voltage-dependent potassium channel, suggest a coupling between activation and inactivation. This coupling is controversial in hERG, a…”
Get full text

Opposite Effects of the S4–S5 Linker and PIP2 on Voltage-Gated Channel Function: KCNQ1/KCNE1 and Other Channels by Choveau, Frank S., Abderemane-Ali, Fayal, Coyan, Fabien C., Es-Salah-Lamoureux, Zeineb, Baró, Isabelle, Loussouarn, Gildas

“…Voltage-gated potassium (Kv) channels are tetramers, each subunit presenting six transmembrane segments (S1–S6), with each S1–S4 segments forming a…”
Get full text

Abstract P2082: Thrombosis In The Coronary Microvasculature May Be Responsible For Impaired Cardiac Relaxation And Diastolic Dysfunction by Paul, Rouault, Guimbal, Sarah, Cornuault, Lauriane, Foussard, Ninon, Bourguignon, Célia, Grouthier, Virginie, Choveau, Frank, Benoist, David, Gadeau, Alain-Pierre, Couffinhal, Thierry, Renault, Marie-Ange

“…Abstract only Introduction: Heart Failure with Preserved Ejection Fraction (HFpEF) is proposed to be caused by endothelial dysfunction in cardiac small…”
Get full text

Thrombosis in the Coronary Microvasculature Impairs Cardiac Relaxation and Induces Diastolic Dysfunction by Rouault, Paul, Guimbal, Sarah, Cornuault, Lauriane, Bourguignon, Célia, Foussard, Ninon, Alzieu, Philippe, Choveau, Frank, Benoist, David, Chapouly, Candice, Gadeau, Alain-Pierre, Couffinhal, Thierry, Renault, Marie-Ange

“…Heart failure with preserved ejection fraction is proposed to be caused by endothelial dysfunction in cardiac microvessels. Our goal was to identify molecular…”
Get full text

Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels by Choveau, Frank, Ben Soussia, Ismail, Bichet, Delphine, Franck, Chatelain, Feliciangeli, Sylvain, Lesage, Florian

“…Inhibitory potassium channels of the TREK1/TRAAK family are integrators of multiple stimuli, including temperature, membrane stretch, polyunsaturated fatty…”
Get full text