Search Results - "Chourasia, Aparajita Hoskote"

Discovery of CDK4/6 bifunctional degraders for ER+/HER2- breast cancer by Majeski, Hannah, Okano, Akinori, Pasis, Angela, Carlson, Casey, Shakya, Arvind, Huang, Shenlin, Chourasia, Aparajita Hoskote, Fung, Leah M., Liu, Qiao

“…1083 Background: CDK4/6 inhibitors (CDK4/6i) such as palbociclib and ribociclib are used to treat ER+/HER2- breast cancer, but patients can develop resistance…”
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BTX-1188, a first-in-class dual degrader of GSPT1 and IKZF1/3, for treatment of acute myeloid leukemia (AML) and solid tumors by Chourasia, Aparajita Hoskote, Majeski, Hannah, Pasis, Angela, Erdman, Paul, Oke, Ashwini, Hecht, David, Lonergan, David, Mercurio, Frank, Chan, Kyle, Thai, Dung Luong, Fung, Leah

“…7025 Background: BTX-1188 is a first-in-class oral molecular glue that degrades GSPT1 and IKZF1/3 and is currently in phase 1 clinical trials for treatment of…”
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Development of bifunctional CRBN-SOS1 degraders for treatment of mutant KRAS cancers by Begovich, Kyle, Schoolmeesters, Angela, Rajapakse, Navin, Kumar, Maneesh, Martinez-Terroba, Elena, Shakya, Arvind, Whitefield, Brandon, Mali, Venkat, Pagadala, Nataraj, Okano, Akinori, Huang, Shenlin, Chourasia, Aparajita Hoskote, Fung, Leah M.

“…3151 Background: KRAS, a GTPase that regulates cellular growth, is the most frequently mutated oncogene in non-small cell lung, pancreatic and colorectal…”
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Abstract 1963: Targeting hematological malignancies with two functionally and mechanistically distinct classes of cereblon mediated protein homeostatic modulators by Chourasia, Aparajita Hoskote, Fung, Leah, Pasis, Angela, McElwee, Brooke, Schoolmeesters, Angela, Richard, Normand, Lam, Imelda, Torres, Eduardo, Erdman, Paul, Sullivan, Robert, Hecht, David, Chan, Kyle W., Mercurio, Frank, Stirling, David I.

“…Abstract BioTheryX's novel and unique Protein Homeostatic Modulators (PHMsTM) are small molecule “molecular glues” that promote ubiquitination of substrate…”
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Bioavailable Dual-Protein Degraders of CK1α and Transcriptional Kinase CDK9 As Potential Therapeutics for Hematological Malignancies by Fung, Leah, Chourasia, Aparajita Hoskote, Torres, Eduardo, Lam, Imelda, Erdman, Paul, Hecht, David, Sullivan, Robert, McElwee, Brooke, Richard, Normand, Venkatachalam, Avanthika, Snir-Alkalay, Irit, Chan, Kyle WH, Mercurio, Frank, Ben-Neriah, Yinon, Stirling, David I

“…BioTheryx's small-molecule kinase inhibitor, BTX-A51 (the ditosylated salt of A51), has recently received FDA approval of its IND application to initiate a…”
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Targeting AML: The Development of Two Functionally and Mechanistically Distinct Classes of Cereblon-Mediated Protein Homeostatic Modulators by Chourasia, Aparajita Hoskote, Fung, Leah, McElwee, Brooke, Richard, Normand, Lam, Imelda, Torres, Eduardo, Erdman, Paul, Sullivan, Robert, Hecht, David, Chan, Kyle WH, Mercurio, Frank, Stirling, David I

“…Targeting disease-relevant proteins by exploiting the cells' very own protein homeostasis machinery is the next generation drug discovery platform that has…”
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Abstract 1553: Discovery of CDK4/6 bifunctional degraders for ER+/HER2- breast cancer andtriple negative breast cancer by Majeski, Hannah, Okano, Akinori, Pasis, Angela, Carlson, Casey, Liu, Qiao, Shakya, Arvind, Huang, Shenlin, Chourasia, Aparajita Hoskote, Fung, Leah

“…Abstract CDK4/6 inhibitors (CDK4/6i) such as palbociclib and ribociclib are used to treatER+/HER2- breast cancer, but patients can develop resistance via…”
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Abstract PO5-05-02: Discovery of BTX-9341, a bifunctional degrader of CDK4 and CDK6 for HR+/HER2- breast cancer by Majeski, Hannah, Okano, Akinori, Chahal, Kirti, Pasis, Angela, Carlson, Casey, Shakya, Arvind, Liu, Qiao, Huang, Shenlin, Chourasia, Aparajita Hoskote, Fung, Leah

“…Abstract CDK4/6 inhibitors (CDK4/6i) such as palbociclib, abemaciclib and ribociclib are used to treat HR+/HER2- breast cancer, but patients can develop…”
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Abstract 5702: BTX-9341, a bifunctional degrader of CDK4 and CDK6 for glioblastoma multiforme by Majeski, Hannah, Chahal, Kirti, Okano, Akinori, Pasis, Angela, Carlson, Casey, Shakya, Arvind, Liu, Qiao, Huang, Shenlin, Chourasia, Aparajita Hoskote, Fung, Leah

“…Abstract Glioblastoma multiforme (GBM) is an aggressive form of brain cancer with limited treatment options. GBM has a high frequency of dysregulation of the…”
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Abstract 6068: Discovery of BTX-9341, a bifunctional degrader of CDK4 and CDK6 for HR+/HER2- breast cancer by Majeski, Hannah, Okano, Akinori, Chahal, Kirti, Pasis, Angela, Carlson, Casey, Shakya, Arvind, Liu, Qiao, Huang, Shenlin, Chourasia, Aparajita Hoskote, Fung, Leah

“…Abstract CDK4/6 inhibitors (CDK4/6i) such as palbociclib, abemaciclib and ribociclib are used to treat HR+/HER2- breast cancer, but patients can develop…”
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Abstract 4316: BNIP3 suppresses mammary tumorigenesis and metastasis through negative regulation of Warburg effect and HIF-1α by Chourasia, Aparajita Hoskote, Tracy, Kristin, Boland, Michelle, Sharifi, Marina, Macleod, Kay F.

“…Abstract BNIP3 is a hypoxia-inducible protein involved in mitochondrial dynamics and mitophagy that is up-regulated at pre-malignant stages of various human…”
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Protein Homeostatic Modulators, a Novel Class of Cereblon-Targeting Small Molecules As Potential Clinical Candidates in Multiple Myeloma by Zou, Jianxuan, Jones, Richard J., Mertz, Janet E., Wang, Hua, Kuiatse, Isere, Sullivan, Bob, Fung, Leah, Richard, Normand, Erdman, Paul, Torres, Eduardo, Chourasia, Aparajita Hoskote, Chan, Kyle WH, Mercurio, Frank, Stirling, David I, Orlowski, Robert Z.

“…Background The immunomodulatory drugs (IMiDs) Thalidomide (THAL), Lenalidomide (LEN), and Pomalidomide (POM) have demonstrated potent anti-multiple myeloma…”
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Tumor suppressive functions of BNIP3 by Chourasia, Aparajita Hoskote

“…BNIP3 is a mitochondrial protein that targets mitochondria for autophagosomal degradation or mitophagy. It is induced under physiological stresses such as…”
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Tumor suppressive functions of BNIP3 by Chourasia, Aparajita Hoskote

“…BNIP3 is a mitochondrial protein that targets mitochondria for autophagosomal degradation or mitophagy. It is induced under physiological stresses such as…”
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