Search Results - "Choudhary, Sinjan"

Inhibition of insulin fibrillation by osmolytes: Mechanistic Insights by Choudhary, Sinjan, Kishore, Nand, Hosur, Ramakrishna V.

“…We have studied here using a number of biophysical tools the effects of osmolytes, betaine, citrulline, proline and sorbitol which differ significantly in…”
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Addressing mechanism of fibrillization/aggregation and its prevention in presence of osmolytes: spectroscopic and calorimetric approach by Choudhary, Sinjan, Kishore, Nand

“…Understanding the mechanism of protein fibrillization/aggregation and its prevention is the basis of development of therapeutic strategies for amyloidosis. An…”
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Elucidation of energetics and mode of recognition of green tea polyphenols by human serum albumin by Save, Shreyada N., Choudhary, Sinjan

“…Green tea is rich in several polyphenols which has many beneficial biological effects. We have done a detailed qualitative and quantitative study on binding of…”
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Insights into the binding of the drugs diclofenac sodium and cefotaxime sodium to serum albumin: Calorimetry and spectroscopy by Sharma, Ruchika, Choudhary, Sinjan, Kishore, Nand

“…Understanding physical chemistry underlying drug–protein interactions is essential to devise guidelines for the synthesis of target oriented drugs. Binding of…”
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Synergistic Inhibition of Protein Fibrillation by Proline and Sorbitol: Biophysical Investigations by Choudhary, Sinjan, Save, Shreyada N, Kishore, Nand, Hosur, Ramakrishna V

“…We report here interesting synergistic effects of proline and sorbitol, two well-known chemical chaperones, in the inhibition of fibrillation of two proteins,…”
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Deciphering the anti-Parkinson's activity of sulphated polysaccharides from Chlamydomonas reinhardtii on the α-Synuclein mutants A30P, A53T, E46K, E57K and E35K by Panigrahi, Gitanjali P, Rane, Ankita R, Vavilala, Sirisha L, Choudhary, Sinjan

“…Parkinsonism-linked mutations in alanine and glutamic acid residues of the pre-synaptic protein α-Synuclein (α-Syn) affect specific tertiary interactions…”
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Unraveling the Energetics and Mode of the Recognition of Antibiotics Tetracycline and Rolitetracycline by Bovine Serum Albumin by Choudhary, Sinjan, Kishore, Nand

“…An understanding of the detailed energetics and mechanism of the binding of drugs with target proteins is essential for devising guidelines to synthesize new…”
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Elucidation of the Tubulin-targeted Mechanism of Action of 9-(3-pyridyl) Noscapine by Pradhan, Swagat, Mahaddalkar, Tejashree, Choudhary, Sinjan, Manhcukonda, Naresh, Nagireddy, Praveen Reddy, Kantevari, Srinivas, Lopus, Manu

“…We have recently reported the synthesis and antiproliferative potential of a series of biaryl type α-noscapine congeners. Among them, 9-(3-pyridyl) noscapine…”
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Interaction of weakly bound antibiotics neomycin and lincomycin with bovine and human serum albumin: biophysical approach by Keswani, Neelam, Choudhary, Sinjan, Kishore, Nand

“…The thermodynamics of interaction of neomycin and lincomycin with bovine serum albumin (BSA) and human serum albumin (HSA) has been studied using isothermal…”
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Quantitative aspects of recognition of the antibiotic drug oxytetracycline by bovine serum albumin: Calorimetric and spectroscopic studies by Keswani, Neelam, Choudhary, Sinjan, Kishore, Nand

“…► Thermodynamics of oxytetracycline (OTC)-bovine serum albumin (BSA) binding addressed. ► ITC and fluorescence spectroscopic analysis provide values of binding…”
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Functional foods and bioactive compounds in the management of neurodegenerative diseases: editorial by Choudhary, Sinjan

“…Malnutrition and poor diet are linked with the development of dementia, ageing and neurodegeneration. Functional foods, nutraceuticals and bioactive compounds…”
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Inhibition of α-Synuclein fibrillation by natural polyphenols: Thermodynamic and biophysical aspects by Tinku, Choudhary, Sinjan

“…[Display omitted] •Binding thermodynamics of EGCG and EC with α-Synuclein was studied using ITC.•Data provide information about nature of interactions between…”
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A thermodynamic approach to understand the partitioning of tetracycline family antibiotics in individual and mixed micellar systems by Tinku, Choudhary, Sinjan

“…•Partitioning of tetracycline antibiotics in surfactant micellar systems were studied.•Partitioning parameters were measured by isothermal titration…”
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Drug–protein interactions in micellar media: Thermodynamic aspects by Choudhary, Sinjan, Kishore, Nand

“…[Display omitted] •Binding of naproxen and diclofenac to serum albumin is modified when delivered from micelles.•Integrity of binding sites is not altered when…”
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Inhibiting the activity of malarial drug target Plasmepsin V by quinolines in aqueous medium by Prajapati, Anitadevi K., Bhattacharya, Anusri, Choudhary, Sinjan

“…[Display omitted] •Expression and purification conditions were optimized to improve yield of PfPlmV.•Conformational characterisation was done using CD and…”
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Physicochemical insights into the micellar delivery of doxycycline and minocycline to the carrier protein in aqueous environment by Tinku, Prajapati, Anitadevi K., Choudhary, Sinjan

“…[Display omitted] •Partitioning of doxycycline/minocycline in surfactant micellar systems were studied.•Partitioning parameters were measured by isothermal…”
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Understanding the partitioning of polyamines in micelles and delivery to the carrier protein: Thermodynamic approach by Tinku, Prajapati, Anitadevi K., Choudhary, Sinjan

“…•Partitioning of polyamines in HTAB micelles were studied.•Partitioning parameters were measured by isothermal titration calorimetry.•Nature of interactions…”
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Thermodynamic insights into drug–surfactant interactions: Study of the interactions of naporxen, diclofenac sodium, neomycin, and lincomycin with hexadecytrimethylammonium bromide by using isothermal titration calorimetry by Choudhary, Sinjan, Talele, Paurnima, Kishore, Nand

“…•Anti-inflammatory, antibiotic drugs interactions studied with HTAB micelles, monomers.•Energetics of drug–surfactant interactions and partitioning in micelles…”
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Inhibition of α-Synuclein fibrillation by curcumin and difluoro boron derivatized curcumin complexes in aqueous environment by Tinku, Shaikh, Shaukat Ali, Priyadarsini, Indira K., Choudhary, Sinjan

“…•Effects of Cur and its derivatives; Cur-BF2 and I-Cur-BF2 on the inhibition of α-Syn fibrillation was investigated.•ITC results showed that curcumin compounds…”
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Role of functional group orientation in the drug partitioning and micelle-mediated delivery of quinoline family drugs to the carrier protein by Syed, Sadaf Fatima, Behera, Siddharth Ranjan, Choudhary, Sinjan

“…[Display omitted] •Partitioning of quinine, quinidine and cinchonidine in HTAB micellar systems was studied.•Partitioning parameters were measured by…”
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