Search Results - "Chou, Leo Y. T"

Strategies for the intracellular delivery of nanoparticles by Chou, Leo Y T, Ming, Kevin, Chan, Warren C W

“…The ability to target contrast agents and therapeutics inside cells is becoming important as we strive to decipher the complex network of events that occur…”
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DNA assembly of nanoparticle superstructures for controlled biological delivery and elimination by Chou, Leo Y. T., Zagorovsky, Kyryl, Chan, Warren C. W.

“…The assembly of nanomaterials using DNA can produce complex nanostructures, but the biological applications of these structures remain unexplored. Here, we…”
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Engineering the Structure and Properties of DNA-Nanoparticle Superstructures Using Polyvalent Counterions by Chou, Leo Y. T, Song, Fayi, Chan, Warren C. W

“…DNA assembly of nanoparticles is a powerful approach to control their properties and prototype new materials. However, the structure and properties of…”
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Controlling DNA–nanoparticle serum interactions by Zagorovsky, Kyryl, Chou, Leo Y. T., Chan, Warren C. W.

“…Understanding the interaction of molecularly assembled nanoparticles with physiological fluids is critical to their use for in vivo delivery of drugs and…”
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Fluorescence-Tagged Gold Nanoparticles for Rapidly Characterizing the Size-Dependent Biodistribution in Tumor Models by Chou, Leo Y. T., Chan, Warren C. W.

“…Nanoparticle vehicles may improve the delivery of contrast agents and therapeutics to diseased tissues, but their rational design is currently impeded by a…”
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Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation by Ponnuswamy, Nandhini, Bastings, Maartje M. C., Nathwani, Bhavik, Ryu, Ju Hee, Chou, Leo Y. T., Vinther, Mathias, Li, Weiwei Aileen, Anastassacos, Frances M., Mooney, David J., Shih, William M.

“…DNA nanostructures have evoked great interest as potential therapeutics and diagnostics due to ease and robustness of programming their shapes, site-specific…”
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Design Verification as Foundation for Advancing DNA Nanotechnology Applications by Chou, Leo Y. T

“…Advances in the field of structural DNA nanotechnology have produced a growing number of nanostructures that are now being developed for diverse applications…”
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Universal, label-free, single-molecule visualization of DNA origami nanodevices across biological samples using origamiFISH by Wang, Wendy Xueyi, Douglas, Travis R., Zhang, Haiwang, Bhattacharya, Afrin, Rothenbroker, Meghan, Tang, Wentian, Sun, Yu, Jia, Zhengping, Muffat, Julien, Li, Yun, Chou, Leo Y. T.

“…Structural DNA nanotechnology enables the fabrication of user-defined DNA origami nanostructures (DNs) for biological applications. However, the role of DN…”
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Tuning the Drug Loading and Release of DNA-Assembled Gold-Nanorod Superstructures by Raeesi, Vahid, Chou, Leo Y. T., Chan, Warren C. W.

“…The use of DNA to assemble inorganic nanoparticles into superstructures is an emerging strategy to build non‐toxic delivery vehicles for targeting diseases in…”
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High‐Throughput, Label‐Free Detection of DNA Origami in Single‐Cell Suspensions Using origamiFISH‐Flow by Alexander, Shana, Wang, Wendy Xueyi, Tseng, Chung‐Yi, Douglas, Travis R., Chou, Leo Y.T.

“…Structural DNA nanotechnology enables custom fabrication of nanoscale devices and promises diverse biological applications. However, the effects of design on…”
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Peptide-Decorated DNA Nanostructures Promote Site-Specific Hydroxyapatite Growth by Danesi, Alexander L, Athanasiadou, Dimitra, Aderinto, Abdulmateen O, Rasie, Prakash, Chou, Leo Y. T, Carneiro, Karina M. M

“…The guiding principle for mineralized tissue formation is that mineral growth occurs through the interaction of Ca2+ and phosphate ions with extracellular…”
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In Vitro Transcriptional Regulation via Nucleic-Acid-Based Transcription Factors by Chou, Leo Y. T, Shih, William M

“…Cells execute complex transcriptional programs by deploying distinct protein regulatory assemblies that interact with cis-regulatory elements throughout the…”
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Visualizing Quantum Dots in Biological Samples Using Silver Staining by Chou, Leo Y. T, Fischer, Hans C, Perrault, Steve D, Chan, Warren C. W

“…Quantum dot (QD) based contrast agents are currently being developed as probes for bioimaging and as vehicles for drug delivery. The ability to detect QDs,…”
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Rewireable Building Blocks for Enzyme-Powered DNA Computing Networks by Lee, Ryan C., Corsano, Ariel, Tseng, Chung Yi, Laohakunakorn, Nadanai, Chou, Leo Y. T.

“…Neural networks enable the processing of large, complex data sets with applications in disease diagnosis, cell profiling, and drug discovery. Beyond electronic…”
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Extrusion of RNA from a DNA-Origami-Based Nanofactory by Hahn, Jaeseung, Chou, Leo Y.T, Sørensen, Rasmus S, Guerra, Richard M, Shih, William M

“…Cells often spatially organize biomolecules to regulate biological interactions. Synthetic mimicry of complex spatial organization may provide a route to…”
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A strategy to assemble nanoparticles with polymers for mitigating cytotoxicity and enabling size tuning by Chou, Leo Y T, Chan, Warren C W

“…We aim to develop a facile strategy for assembling nanoparticles within cross-linked polymer micelles that enables tuning of their overall hydrodynamic size…”
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Engineering DNA Nanostructures to Manipulate Immune Receptor Signaling and Immune Cell Fates by Tseng, Chung Yi, Wang, Wendy Xueyi, Douglas, Travis Robert, Chou, Leo Y. T.

“…Immune cells sense, communicate, and logically integrate a multitude of environmental signals to make important cell‐fate decisions and fulfill their effector…”
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Precision nanoscale patterning of TLR ligands for improved cancer immunotherapy by Tseng, Chung Yi, Murtada, Farshad, Chou, Leo Y.T.

“…In a recent issue of Nature Nanotechnology, Zeng et al. report that arraying immuno-stimulatory CpG molecules with specific nanoscale spacing on DNA origami…”
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DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation by Lee, Ryan C, Douglas, Travis R, Chou, Leo Y T

“…DNA nanotechnology enables programmable self-assembly of nucleic acids into user-prescribed shapes and dynamics for diverse applications. This work…”
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Nanotoxicology. No signs of illness by Chou, Leo Y T, Chan, Warren C W

“…Quantum dots that contain cadmium, selenium and zinc are not toxic to monkeys for periods of up to 90 days, but longer-term studies are needed to determine the…”
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