Search Results - "Chou, James J."

Molecular Basis for Interaction of let-7 MicroRNAs with Lin28 by Nam, Yunsun, Chen, Casandra, Gregory, Richard I., Chou, James J., Sliz, Piotr

“…MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate gene expression. Among these, members of the let-7 miRNA family control many cell-fate…”
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Structure and mechanism of the M2 proton channel of influenza A virus by Schnell, Jason R, Chou, James J

“…The integral membrane protein M2 of influenza virus forms pH-gated proton channels in the viral lipid envelope. The low pH of an endosome activates the M2…”
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Architecture of the mitochondrial calcium uniporter by Oxenoid, Kirill, Dong, Ying, Cao, Chan, Cui, Tanxing, Sancak, Yasemin, Markhard, Andrew L., Grabarek, Zenon, Kong, Liangliang, Liu, Zhijun, Ouyang, Bo, Cong, Yao, Mootha, Vamsi K., Chou, James J.

“…The structure of the core region of the mitochondrial calcium uniporter (MCU) is determined by NMR and electron microscopy, revealing that MCU is a…”
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Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor by Fu, Qingshan, Fu, Tian-Min, Cruz, Anthony C., Sengupta, Prabuddha, Thomas, Stacy K., Wang, Shuqing, Siegel, Richard M., Wu, Hao, Chou, James J.

“…Fas (CD95, Apo-1, or TNFRSF6) is a prototypical apoptosis-inducing death receptor in the tumor necrosis factor receptor (TNFR) superfamily. While the…”
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Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling by Pan, Liqiang, Fu, Tian-Min, Zhao, Wenbin, Zhao, Linlin, Chen, Wen, Qiu, Chixiao, Liu, Wenhui, Liu, Zhijun, Piai, Alessandro, Fu, Qingshan, Chen, Shuqing, Wu, Hao, Chou, James J.

“…Receptor clustering on the cell membrane is critical in the signaling of many immunoreceptors, and this mechanism has previously been attributed to the…”
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Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching by Berardi, Marcelo J., Shih, William M., Harrison, Stephen C., Chou, James J.

“…Mitochondrial proton transport The transport of small molecules across the inner mitochondrial membrane is catalysed by a large family of membrane proteins…”
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Structural basis for membrane anchoring of HIV-1 envelope spike by Dev, Jyoti, Park, Donghyun, Fu, Qingshan, Chen, Jia, Ha, Heather Jiwon, Ghantous, Fadi, Herrmann, Tobias, Chang, Weiting, Liu, Zhijun, Frey, Gary, Seaman, Michael S., Chen, Bing, Chou, James J.

“…HIV-1 envelope spike (Env) is a type I membrane protein that mediates viral entry. We used nuclear magnetic resonance to determine an atomic structure of the…”
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Unusual architecture of the p7 channel from hepatitis C virus by OuYang, Bo, Xie, Shiqi, Berardi, Marcelo J., Zhao, Xinhao, Dev, Jyoti, Yu, Wenjing, Sun, Bing, Chou, James J.

“…The structure of the oligomeric hepatitis C virus viroporin p7 protein, solved by NMR spectroscopy, is reported; this protein can self-assemble into a channel…”
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Fatty Acid Flippase Activity of UCP2 Is Essential for Its Proton Transport in Mitochondria by Berardi, Marcelo J., Chou, James J.

“…Modulation of cellular energy expenditure is fundamental to normal and pathological cell growth and differentiation. Mitochondria stores energy as a proton…”
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DNA-nanotube-induced alignment of membrane proteins for NMR structure determination by Douglas, Shawn M, Chou, James J, Shih, William M

“…Membrane proteins are encoded by 20-35% of genes but represent <1% of known protein structures to date. Thus, improved methods for membrane-protein structure…”
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Ion and inhibitor binding of the double-ring ion selectivity filter of the mitochondrial calcium uniporter by Cao, Chan, Wang, Shuqing, Cui, Tanxing, Su, Xun-Cheng, Chou, James J.

“…The calcium (Ca2+) uniporter of mitochondria is a holocomplex consisting of the Ca2+-conducting channel, known as mitochondrial calcium uniporter (MCU), and…”
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Mechanism of drug inhibition and drug resistance of influenza A M2 channel by Pielak, Rafal M, Schnell, Jason R, Chou, James J

“…The influenza A virus M2 proton channel equilibrates pH across the viral membrane during entry and across the trans-Golgi membrane of infected cells during…”
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Structure of the membrane proximal external region of HIV-1 envelope glycoprotein by Fu, Qingshan, Shaik, Md Munan, Cai, Yongfei, Ghantous, Fadi, Piai, Alessandro, Peng, Hanqin, Rits-Volloch, Sophia, Liu, Zhijun, Harrison, Stephen C., Seaman, Michael S., Chen, Bing, Chou, James J.

“…The membrane-proximal external region (MPER) of the HIV-1 envelope glycoprotein (Env) bears epitopes of broadly neutralizing antibodies (bnAbs) from infected…”
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Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance by Zhuang, Xinlei, Wang, Zhe, Fan, Jiansheng, Bai, Xuefei, Xu, Yingchun, Chou, James J., Hou, Tingjun, Chen, Shuqing, Pan, Liqiang

“…Acquired resistance to cetuximab in colorectal cancers is partially mediated by the acquisition of mutations located in the cetuximab epitope in the epidermal…”
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Editorial: Targeting TNF/TNFR signaling pathways by Pan, Liqiang, Chou, James J, Fu, Tianmin

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MemBrain: improving the accuracy of predicting transmembrane helices by Shen, Hongbin, Chou, James J

“…Prediction of transmembrane helices (TMH) in alpha helical membrane proteins provides valuable information about the protein topology when the high resolution…”
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Substrate-modulated ADP/ATP-transporter dynamics revealed by NMR relaxation dispersion by Brüschweiler, Sven, Yang, Qin, Run, Changqing, Chou, James J

“…NMR relaxation dispersion measurements reveal the conformational dynamics of the mitochondrial ADP/ATP carrier and show that the ADP substrate facilitates…”
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Structural Investigation of Rimantadine Inhibition of the AM2-BM2 Chimera Channel of Influenza Viruses by Pielak, Rafal M., Oxenoid, Kirill, Chou, James J.

“…The M2 channel of influenza A is a target of the adamantane family antiviral drugs. Two different drug-binding sites have been reported: one inside the pore,…”
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The Structure of Phospholamban Pentamer Reveals a Channel-Like Architecture in Membranes by Oxenoid, Kirill, Chou, James J., Harrison, Stephen C.

“…Contraction and relaxation of heart muscle cells is regulated by cycling of calcium between cytoplasm and sarcoplasmic reticulum. Human phospholamban (PLN),…”
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Structural basis of transmembrane coupling of the HIV-1 envelope glycoprotein by Piai, Alessandro, Fu, Qingshan, Cai, Yongfei, Ghantous, Fadi, Xiao, Tianshu, Shaik, Md Munan, Peng, Hanqin, Rits-Volloch, Sophia, Chen, Wen, Seaman, Michael S., Chen, Bing, Chou, James J.

“…The prefusion conformation of HIV-1 envelope protein (Env) is recognized by most broadly neutralizing antibodies (bnAbs). Studies showed that alterations of…”
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