Search Results - "Chordia, Mahendra"

Validation of metal-binding sites in macromolecular structures with the CheckMyMetal web server by Zheng, Heping, Chordia, Mahendra D, Cooper, David R, Chruszcz, Maksymilian, Müller, Peter, Sheldrick, George M, Minor, Wladek

“…Metals have vital roles in both the mechanism and architecture of biological macromolecules. Yet structures of metal-containing macromolecules in which metals…”
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Critical role of FPR1 in splenocyte migration into brain to worsen inflammation and ischemic brain injury in mice by Li, Jun, Chordia, Mahendra D, Zhang, Yi, Zong, Hui, Pan, Dongfeng, Zuo, Zhiyi

“…Splenocyte contribution to ischemic brain injury has been suggested. It is not known whether this effect is due to systemic action or direct influence in…”
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Targeted Antioxidant Therapy Reduces Hyperglycemic Exacerbation of Myocardial Ischemia/Reperfusion Injury by Rastogi, Radhika, Marsh, Katherine, Zhang, Aimee Y., Wu, Di, Chordia, Mahendra D., Pan, Dongfeng, Kron, Irving L., Yang, Zequan

“…Acute hyperglycemia (HG) enhances inflammatory and oxidative stress and exacerbates myocardial infarct size during ischemia-reperfusion injury by activating…”
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Targeted Antioxidant Therapy Reduces Hyperglycemic Exacerbation of Myocardial Ischemia-Reperfusion by Rastogi, Radhika, Marsh, Katherine, Zhang, Aimee Y, Wu, Di, Chordia, Mahendra D, Pan, Dongfeng, Kron, Irving L, Yang, Zequan

“…Acute hyperglycemia (HG) enhances inflammatory and oxidative stress and exacerbates myocardial infarct size during ischemia-reperfusion injury by activating…”
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A Metabolic‐Tag‐Based Method for Assessing the Permeation of Small Molecules Across the Mycomembrane in Live Mycobacteria by Liu, Zichen, Lepori, Irene, Chordia, Mahendra D., Dalesandro, Brianna E., Guo, Taijie, Dong, Jiajia, Siegrist, M. Sloan, Pires, Marcos M.

“…The general lack of permeability of small molecules observed for Mycobacterium tuberculosis (Mtb) is most ascribed to its unique cell envelope. More…”
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Measurement of Accumulation of Antibiotics to Staphylococcus aureus in Phagosomes of Live Macrophages by Kelly, Joey J., Dalesandro, Brianna E., Liu, Zichen, Chordia, Mahendra D., Ongwae, George M., Pires, Marcos M.

“…Staphylococcus aureus (S. aureus) has evolved the ability to persist after uptake into host immune cells. This intracellular niche enables S. aureus to…”
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The spleen contributes importantly to myocardial infarct exacerbation during post-ischemic reperfusion in mice via signaling between cardiac HMGB1 and splenic RAGE by Tian, Yikui, Pan, Dongfeng, Chordia, Mahendra D., French, Brent A., Kron, Irving L., Yang, Zequan

“…The spleen plays a critical role in post-infarct myocardial remodeling. However, the role of the spleen in exacerbating myocardial infarction (MI) during acute…”
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Targeting of Pseudomonas aeruginosa cell surface via GP12, an Escherichia coli specific bacteriophage protein by Ongwae, George M., Chordia, Mahendra D., Cawley, Jennie L., Dalesandro, Brianna E., Wittenberg, Nathan J., Pires, Marcos M.

“…Bacteriophages are highly abundant molecular machines that have evolved proteins to target the surface of host bacterial cells. Given the ubiquity of…”
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Noninvasive Analysis of Peptidoglycan from Living Animals by Ocius, Karl L., Kolli, Sree H., Ahmad, Saadman S., Dressler, Jules M., Chordia, Mahendra D., Jutras, Brandon L., Rutkowski, Melanie R., Pires, Marcos M.

“…The role of the intestinal microbiota in host health is increasingly revealed in its contributions to disease states. The host-microbiome interaction is…”
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Metabolic Changes in Spontaneously Hypertensive Rat Hearts Precede Cardiac Dysfunction and Left Ventricular Hypertrophy by Li, Jie, Kemp, Brandon A, Howell, Nancy L, Massey, James, Mińczuk, Krzysztof, Huang, Qiao, Chordia, Mahendra D, Roy, R Jack, Patrie, James T, Davogustto, Giovanni E, Kramer, Christopher M, Epstein, Frederick H, Carey, Robert M, Taegtmeyer, Heinrich, Keller, Susanna R, Kundu, Bijoy K

“…Background Sustained pressure overload leads to changes in cardiac metabolism, function, and structure. Both time course and causal relationships between these…”
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Synthesis and Biological Evaluation of Genistein-IR783 Conjugate: Cancer Cell Targeted Delivery in MCF-7 for Superior Anti-Cancer Therapy by Guan, Yang, Zhang, Yi, Zou, Juan, Huang, Li-Ping, Chordia, Mahendra D, Yue, Wei, Wu, Jin-Jun, Pan, Dong-Feng

“…The flavonoid-based natural product genistein is a biologically active compound possessing promising anti-oxidant and anti-cancer properties. Poor…”
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Multimodal formyl peptide receptor 1 targeted inflammation imaging probe: cFLFLF-MHI-DOTA by Li, Jie, Zhang, Yi, Chordia, Mahendra D., Wu, Hua, Shao, Li, Pan, Dongfeng

“…[Display omitted] Formyl peptide receptor 1 (FPR1) targeting multimodal probe cFLFLFK-MHI-DOTA for leukocyte based inflammation imaging is described. The…”
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Single-Photon Emission Computed Tomography Imaging Using Formyl Peptide Receptor 1 Ligand Can Diagnose Aortic Aneurysms in a Mouse Model by Shannon, Alexander H., Chordia, Mahendra D., Spinosa, Michael D., Su, Gang, Ladd, Zachary, Pan, Dongfeng, Upchurch, Gilbert R., Sharma, Ashish K.

“…Our previous studies showed that neutrophil infiltration and activation plays an important role in the pathogenesis of abdominal aortic aneurysms (AAA)…”
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SPECT imaging of lung ischemia-reperfusion injury using [ 99m Tc]cFLFLF for molecular targeting of formyl peptide receptor 1 by Charles, Eric J, Chordia, Mahendra D, Zhao, Yunge, Zhang, Yi, Mehaffey, J Hunter, Glover, David K, Dimastromatteo, Julien, Chancellor, W Zachary, Sharma, Ashish K, Kron, Irving L, Pan, Dongfeng, Laubach, Victor E

“…Primary graft dysfunction after lung transplantation, a consequence of ischemia-reperfusion injury (IRI), is a major cause of morbidity and mortality. IRI…”
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Microbiota-Produced N -Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance by Wollam, Joshua, Riopel, Matthew, Xu, Yong-Jiang, Johnson, Andrew M F, Ofrecio, Jachelle M, Ying, Wei, El Ouarrat, Dalila, Chan, Luisa S, Han, Andrew W, Mahmood, Nadir A, Ryan, Caitlin N, Lee, Yun Sok, Watrous, Jeramie D, Chordia, Mahendra D, Pan, Dongfeng, Jain, Mohit, Olefsky, Jerrold M

“…The composition of the gastrointestinal microbiota and associated metabolites changes dramatically with diet and the development of obesity. Although many…”
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Bioluminescence-Based Determination of Cytosolic Accumulation of Antibiotics in Escherichia coli by Dash, Rachita, Holsinger, Kadie A., Chordia, Mahendra D., Gh, Mohammad Sharifian, Pires, Marcos M.

“…Antibiotic resistance is an alarming public health concern that affects millions of individuals across the globe each year. A major challenge in the…”
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Detection of Osteoarthritis Inflammation by Single-Photon Emission Computed Tomography Based on an Inflammation-Targeting Peptide cFLFLF by Yang, Xinlin, Ignozzi, Anthony J., He, Rui, Zhu, Di, Wang, Xisha, Chordia, Mahendra D., Pan, Dongfeng, Cui, Quanjun

“…Purpose Although inflammation has been recognized as a key process in the pathogenesis of osteoarthritis (OA), there remains no clinical noninvasive imaging…”
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Targeting formyl peptide receptor 1 of activated macrophages to monitor inflammation of experimental osteoarthritis in rat by Yang, Xinlin, Chordia, Mahendra D., Du, Xuejun, Graves, John L., Zhang, Yi, Park, Yong-Sang, Guo, Yongfei, Pan, Dongfeng, Cui, Quanjun

“…ABSTRACT Macrophages play a crucial role in the pathogenesis of osteoarthritis (OA). In this study, the feasibility of a formyl peptide receptor 1…”
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Progressive Cardiac Metabolic Defects Accompany Diastolic and Severe Systolic Dysfunction in Spontaneously Hypertensive Rat Hearts by Li, Jie, Minczuk, Krzysztof, Huang, Qiao, Kemp, Brandon A, Howell, Nancy L, Chordia, Mahendra D, Roy, R Jack, Patrie, James T, Qureshi, Zoraiz, Kramer, Christopher M, Epstein, Frederick H, Carey, Robert M, Kundu, Bijoy K, Keller, Susanna R

“…Background Cardiac metabolic abnormalities are present in heart failure. Few studies have followed metabolic changes accompanying diastolic and systolic heart…”
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Hydroamination of Dihapto‐Coordinated Benzene and Diene Complexes of Tungsten: Fundamental Studies and the Synthesis of γ‐Lycorane by Wilson, Katy B., Nedzbala, Hannah S., Simpson, Spenser R., Ericson, Megan N., Westendorff, Karl S., Chordia, Mahendra D., Dickie, Diane A., Harman, W. Dean

“…Reactions are described for complexes of the form WTp(NO)(PMe3)(η2‐arene) and various amines, where the arene is benzene or benzene with an…”
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