Search Results - "Chopra, Sameer S"

Voltage-Gated Sodium Channels Are Required for Heart Development in Zebrafish by Chopra, Sameer S, Stroud, Dina Myers, Watanabe, Hiroshi, Bennett, Jeffrey S, Burns, C. Geoffrey, Wells, K. Sam, Yang, Tao, Zhong, Tao P, Roden, Dan M

“…RATIONALE:Voltage-gated sodium channels initiate action potentials in excitable tissues. Mice in which Scn5A (the predominant sodium channel gene in heart) has…”
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Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates by Chopra, Sameer S, Watanabe, Hiroshi, Zhong, Tao P, Roden, Dan M

“…Action potential generation in excitable cells such as myocytes and neurons critically depends on voltage-gated sodium channels. In mammals, sodium channels…”
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Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5 by Jia, Haibo, King, Isabelle N, Chopra, Sameer S, Wan, Haiyan, Ni, Terri T, Jiang, Charlie, Guan, Xiaoqun, Wells, Sam, Srivastava, Deepak, Zhong, Tao P

“…Embryonic organs attain their final dimensions through the generation of proper cell number and size, but the control mechanisms remain obscure. Here, we…”
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Homozygous PLCB1 deletion associated with malignant migrating partial seizures in infancy by Poduri, Annapurna, Chopra, Sameer S., Neilan, Edward G., Christina Elhosary, P., Kurian, Manju A., Meyer, Esther, Barry, Brenda J., Khwaja, Omar S., Salih, Mustafa A. M., Stödberg, Tommy, Scheffer, Ingrid E., Maher, Eamonn R., Sahin, Mustafa, Wu, Bai-Lin, Berry, Gerard T., Walsh, Christopher A., Picker, Jonathan, Kothare, Sanjeev V.

“…Summary Malignant migrating partial seizures in infancy (MMPEI) is an early onset epileptic encephalopathy with few known etiologies. We sought to identify a…”
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Industry Funding of Clinical Trials: Benefit or Bias? by Chopra, Sameer S

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737 A phase 1/1b study of the tumor-activated IL-2 prodrug WTX-124 alone or in combination with pembrolizumab in patients with immunotherapy-sensitive locally advanced or metastatic solid tumors by Moser, Justin C, Opyrchal, Mateusz, Rivera, Ildefonso Rodriguez, Bilen, Mehmet A, Curti, Brendan, Puzanov, Igor, Morris, Kristin, Nirschl, Christopher J, Park, Saero, Bruno, Marissa, Windt, Paul, Subramanian, Kulandayan K, Chopra, Sameer S, Isaacs, Randi

“…BackgroundHigh-dose IL-2 is an FDA-approved immunotherapy that produces durable remissions in patients with melanoma and renal cell carcinoma (RCC) but is…”
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A germline or de novo mutation in two families with Gaucher disease: implications for recessive disorders by Saranjam, Hamid, Chopra, Sameer S, Levy, Harvey, Stubblefield, Barbara K, Maniwang, Emerson, Cohen, Ian J, Baris, Hagit, Sidransky, Ellen, Tayebi, Nahid

“…Gaucher disease (GD) is an autosomal recessive storage disorder that most commonly results from the inheritance of one identifiable mutant glucocerebrosidase…”
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An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery by Haghighi, Alireza, Krier, Joel B., Toth-Petroczy, Agnes, Cassa, Christopher A., Frank, Natasha Y., Carmichael, Nikkola, Fieg, Elizabeth, Bjonnes, Andrew, Mohanty, Anwoy, Briere, Lauren C., Lincoln, Sharyn, Lucia, Stephanie, Gupta, Vandana A., Söylemez, Onuralp, Sutti, Sheila, Kooshesh, Kameron, Qiu, Haiyan, Fay, Christopher J., Perroni, Victoria, Valerius, Jamie, Hanna, Meredith, Frank, Alexander, Ouahed, Jodie, Snapper, Scott B., Pantazi, Angeliki, Chopra, Sameer S., Leshchiner, Ignaty, Stitziel, Nathan O., Feldweg, Anna, Mannstadt, Michael, Loscalzo, Joseph, Sweetser, David A., Liao, Eric, Stoler, Joan M., Nowak, Catherine B., Sanchez-Lara, Pedro A., Klein, Ophir D., Perry, Hazel, Patsopoulos, Nikolaos A., Raychaudhuri, Soumya, Goessling, Wolfram, Green, Robert C., Seidman, Christine E., MacRae, Calum A., Sunyaev, Shamil R., Maas, Richard L., Vuzman, Dana

“…Despite major progress in defining the genetic basis of Mendelian disorders, the molecular etiology of many cases remains unknown. Patients with these…”
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ST-segment abnormalities and premature complexes are predictors of new-onset atrial fibrillation: The Niigata Preventive Medicine Study by Watanabe, Hiroshi, Tanabe, Naohito, Makiyama, Yashiro, Chopra, Sameer S., Okura, Yuji, Suzuki, Hiroshi, Matsui, Kazumitsu, Watanabe, Toru, Kurashina, Yoshiaki, Aizawa, Yoshifusa

“…Left ventricular hypertrophy is a known risk factor for atrial fibrillation (AF). However, it is not well understood whether other electrocardiogram…”
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Physician Burnout by Chopra, Sameer S, Sotile, Wayne M, Sotile, Mary O

“…Burnout is a syndrome defined by the three principal components of emotional exhaustion, depersonalization, and diminished feelings of personal accomplishment…”
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Inherited CHST11/MIR3922 deletion is associated with a novel recessive syndrome presenting with skeletal malformation and malignant lymphoproliferative disease by Chopra, Sameer S., Leshchiner, Ignaty, Duzkale, Hatice, McLaughlin, Heather, Giovanni, Monica, Zhang, Chengsheng, Stitziel, Nathan, Fingeroth, Joyce, Joyce, Robin M., Lebo, Matthew, Rehm, Heidi, Vuzman, Dana, Maas, Richard, Sunyaev, Shamil R., Murray, Michael, Cassa, Christopher A.

“…Glycosaminoglycans (GAGs) such as chondroitin are ubiquitous disaccharide carbohydrate chains that contribute to the formation and function of proteoglycans at…”
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Management of patients with newly diagnosed epilepsy: a systematic literature review by Ross, Susan, Estok, Rhonda P, Chopra, Sameer S, French, Jacqueline

“…Ross et al discuss the process of conducting their medical study about management of patients with newly diagnosed epilepsy. They present several key project…”
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Abstract AP22: DNA DAMAGE RESPONSES AND IMMUNE PROFILING THROUGH HIGHLY MULTIPLEXED TISSUE IMMUNOFLUORESCENCE (T-CYCIF) IN HIGH-GRADE SEROUS OVARIAN CANCER by Färkkilä, Anniina, Lin, Jia-Ren, Maliga, Zoltan, Chopra, Sameer S., Koruchupakkal, Bose, Howitt, Brooke E., Strickland, Kyle C., Santagata, Sandro, Swisher, Elizabeth M., Matulonis, Ursula A., Guerriero, Jennifer. L., Elias, Kevin, Konstantinopoulos, Panagiotis, Sorger, Peter K., D'Andrea, Alan D.

“…Abstract INTRODUCTION: Immune checkpoint blockade (ICB) has emerged as a new therapeutic approach for multiple cancers, however, the responses to single-agent…”
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Abstract B103: Torin2 and related analogs exploit replicative and checkpoint vulnerabilities to induce death of triple-negative breast cancer cells by Chopra, Sameer S., Jenney, Annie, Palmer, Adam, Niepel, Mario, Chung, Mirra, Mills, Caitlin, Sivakumaren, Sindhu Carmen, Liu, Qingsong, Chen, Jia-Yun, Yapp, Clarence, Gray, Nathanael S., Sorger, Peter K.

“…Abstract Frequent mutation of genes in the PI3K/AKT/mTOR signaling pathway in human cancers has stimulated large investments in over 40 small molecule…”
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Abstract 139: DNA damage and immunoprofiling with highly multiplexed tissue immunofluorescence (t-CycIF) in high-grade serous ovarian cancer by Farkkila, Anniina, Chopra, Sameer S., Lin, Jia-Ren, Maliga, Zoltan, Koruchupakkal, Bose, Strickland, Kyle C., Howitt, Brooke E., Santagata, Sandro, Matulonis, Ursula A., Elias, Kevin, Swisher, Elizabeth M., Konstantinopoulos, Panagiotis A., Sorger, Peter, D'Andrea, Alan D.

“…Abstract Immune checkpoint blockade (ICB) has emerged as a new promising therapeutic approach in multiple cancers, however, the responses to single-agent ICBs…”
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Abstract CT254: Trial in progress: a first-in-human, phase 1, multicenter dose escalation and dose expansion study of WTX-330 in adult patients with advanced or metastatic solid tumors or non-Hodgkin lymphoma by Rodriguez-Rivera, Ildefonso Ismael, Moser, Justin C., Opyrchal, Mateusz, Parikh, Aparna R., Park, Saero, Bruno, Marissa, Windt, Paul, Subramanian, Kulandayan K., Chopra, Sameer S., Isaacs, Randi

“…Abstract Background: Interleukin-12 (IL-12) is a potent proinflammatory cytokine with activating effects on both innate and adaptive immune cells. Though…”
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Abstract CT133: Trial in progress: a multicenter phase 1/1b dose escalation study of WTX-124 as a monotherapy and in combination with pembrolizumab in patients with selected advanced or metastatic solid tumors by Rodriguez-Rivera, Ildefonso Ismael, Moser, Justin C., Opyrchal, Mateusz, Curti, Brendan, Bilen, Mehmet A., Park, Saero, Bruno, Marissa, Windt, Paul, Subramanian, Kulandayan K., Chopra, Sameer S., Isaacs, Randi

“…Abstract Background: High-dose recombinant human IL-2 (HD IL-2) is an FDA-approved therapy that produces durable complete remissions in a subset of patients…”
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Preparing for Personalized Medicine by Chopra, Sameer S

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Industry funding of clinical trials: Benefits or bias? by Chopra, Sameer S

“…The pharmaceutical industry plays a vital role in financing the research required to develop new drugs. Understanding the advantages and drawbacks of…”
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Abstract 356: Loss of Function Mutations of Sodium Channel Beta-1 and Beta-2 Subunits Associated with Atrial Fibrillation and ST-segment Elevation by Watanabe, Hiroshi, Darbar, Dawood, Ingram, Christiana R, Jiramongkolchai, Kim, Chopra, Sameer S, Kucera, Gayle, Stubblefield, Tanya, Wang, Janey, Roden, Dan M

“…Abstract only Background: We have recently reported mutations in the cardiac sodium channel gene SCN5A in 5.9% of patients with atrial fibrillation (AF). In…”
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