Search Results - "Chopra, Manan"

Restoring vision and rebuilding the retina by Müller glial cell reprogramming by Agarwal, Devansh, Do, Hope, Mazo, Kevin W., Chopra, Manan, Wahlin, Karl J.

“…•Many species including fish, amphibians and chickens can regenerate their retinas.•In mammals, regeneration does not commonly occur.•Müller glia are…”
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Optimal allocation of replicas in parallel tempering simulations by Rathore, Nitin, Chopra, Manan, de Pablo, Juan J

“…We have studied the efficiency of parallel tempering simulations for a variety of systems including a coarse-grained protein, an atomistic model polypeptide,…”
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Density of States-Based Molecular Simulations by Singh, Sadanand, Chopra, Manan, de Pablo, Juan J

“…One of the central problems in statistical mechanics is that of finding the density of states of a system. Knowledge of the density of states of a system is…”
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Human retinal ganglion cell neurons generated by synchronous BMP inhibition and transcription factor mediated reprogramming by Agarwal, Devansh, Dash, Nicholas, Mazo, Kevin W., Chopra, Manan, Avila, Maria P., Patel, Amit, Wong, Ryan M., Jia, Cairang, Do, Hope, Cheng, Jie, Chiang, Colette, Jurlina, Shawna L., Roshan, Mona, Perry, Michael W., Rho, Jong M., Broyer, Risa, Lee, Cassidy D., Weinreb, Robert N., Gavrilovici, Cezar, Oesch, Nicholas W., Welsbie, Derek S., Wahlin, Karl J.

“…In optic neuropathies, including glaucoma, retinal ganglion cells (RGCs) die. Cell transplantation and endogenous regeneration offer strategies for retinal…”
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Chromatin Accessibility and Transcriptional Differences in Human Stem Cell-Derived Early-Stage Retinal Organoids by Jones, Melissa K, Agarwal, Devansh, Mazo, Kevin W, Chopra, Manan, Jurlina, Shawna L, Dash, Nicholas, Xu, Qianlan, Ogata, Anna R, Chow, Melissa, Hill, Alex D, Kambli, Netra K, Xu, Guorong, Sasik, Roman, Birmingham, Amanda, Fisch, Kathleen M, Weinreb, Robert N, Enke, Ray A, Skowronska-Krawczyk, Dorota, Wahlin, Karl J

“…Retinogenesis involves the specification of retinal cell types during early vertebrate development. While model organisms have been critical for determining…”
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Hydrodynamic effects on the translocation rate of a polymer through a pore by Hernández-Ortiz, Juan P, Chopra, Manan, Geier, Stephanie, de Pablo, Juan J

“…The translocation of large DNA molecules through narrow pores has been examined in the context of multiscale simulations that include a full coupling of…”
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GNNQQNY—Investigation of Early Steps during Amyloid Formation by Reddy, Allam S., Chopra, Manan, de Pablo, Juan J.

“…Protein aggregation has been implicated in the pathology of several neurodegenerative diseases, and a better understanding of how it proceeds is essential for…”
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Solution Structures of Rat Amylin Peptide: Simulation, Theory, and Experiment by Reddy, Allam S., Wang, Lu, Lin, Yu-Shan, Ling, Yun, Chopra, Manan, Zanni, Martin T., Skinner, James L., De Pablo, Juan J.

“…Amyloid deposits of amylin in the pancreas are an important characteristic feature found in patients with Type-2 diabetes. The aggregate has been considered…”
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Folding of polyglutamine chains by Chopra, Manan, Reddy, Allam S, Abbott, N L, de Pablo, J J

“…Long polyglutamine chains have been associated with a number of neurodegenerative diseases. These include Huntington's disease, where expanded polyglutamine…”
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Improved transition path sampling methods for simulation of rare events by Chopra, Manan, Malshe, Rohit, Reddy, Allam S, de Pablo, J J

“…The free energy surfaces of a wide variety of systems encountered in physics, chemistry, and biology are characterized by the existence of deep minima…”
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Molecular simulations of rare events by Chopra, Manan

“…Rare events are transitions between stable separated by a high free energy barrier. Conventional simulation techniques like Molecular dynamics and Monte Carlo…”
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Interactions of Liquid Crystal-Forming Molecules with Phospholipid Bilayers Studied by Molecular Dynamics Simulations by Kim, Evelina B., Lockwood, Nathan, Chopra, Manan, Guzmán, Orlando, Abbott, Nicholas L., de Pablo, Juan J.

“…Recent experiments have shown that liquid crystals can be used to image mammalian cell membranes and to amplify structural reorganization in phospholipid-laden…”
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Molecular simulations of rare events by Chopra, Manan

“…Rare events are transitions between stable separated by a high free energy barrier. Conventional simulation techniques like Molecular dynamics and Monte Carlo…”
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