Search Results - "Choong, Yeu Khai"

Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides by Saravanan, Rathi, Holdbrook, Daniel A, Petrlova, Jitka, Singh, Shalini, Berglund, Nils A, Choong, Yeu Khai, Kjellström, Sven, Bond, Peter J, Malmsten, Martin, Schmidtchen, Artur

“…Thrombin-derived C-terminal peptides (TCPs) of about 2 kDa are present in wounds, where they exert anti-endotoxic functions. Employing a combination of nuclear…”
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Identification of Aedes aegypti salivary gland proteins interacting with human immune receptor proteins by Gavor, Edem, Choong, Yeu Khai, Liu, Yonghao, Pompon, Julien, Ooi, Eng Eong, Mok, Yu Keung, Liu, Haiyan, Kini, R Manjunatha, Sivaraman, J

“…Mosquito saliva proteins modulate the human immune and hemostatic systems and control mosquito-borne pathogenic infections. One mechanism through which…”
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Thrombin and Plasmin Alter the Proteome of Neutrophil Extracellular Traps by Lim, Chun Hwee, Adav, Sunil S, Sze, Siu Kwan, Choong, Yeu Khai, Saravanan, Rathi, Schmidtchen, Artur

“…Neutrophil extracellular traps (NETs) consist of a decondensed DNA scaffold decorated with neutrophil-derived proteins. The proteome of NETs, or "NETome," has…”
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Binary Toxin Subunits of Lysinibacillus sphaericus Are Monomeric and Form Heterodimers after In Vitro Activation by Surya, Wahyu, Chooduang, Sivadatch, Choong, Yeu Khai, Torres, Jaume, Boonserm, Panadda

“…The binary toxin from Lysinibacillus sphaericus has been successfully used for controlling mosquito-transmitted diseases. An activation step shortens both…”
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Cell-Free DNA Promotes Thrombin Autolysis and Generation of Thrombin-Derived C-Terminal Fragments by Saravanan, Rathi, Choong, Yeu Khai, Lim, Chun Hwee, Lim, Li Ming, Petrlova, Jitka, Schmidtchen, Artur

“…Cell-free DNA (cfDNA) is the major structural component of neutrophil extracellular traps (NETs), an innate immune response to infection. Antimicrobial…”
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Structural Basis for the Enzymatic Activity of the HACE1 HECT-Type E3 Ligase Through N-Terminal Helix Dimerization by Singh, Sunil, Machida, Satoru, Tulsian, Nikhil Kumar, Choong, Yeu Khai, Ng, Joel, Shankar, Srihari, Liu, Yaochen, Chandiramani, Krisha Vashdev, Shi, Jian, Sivaraman, J

“…HACE1 is an ankyrin repeat (AKR) containing HECT-type E3 ubiquitin ligase that interacts with and ubiquitinates multiple substrates. While HACE1 is a…”
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Structural Basis of SARS-CoV-2 and SARS-CoV Antibody Interactions by Gavor, Edem, Choong, Yeu Khai, Er, Shi Yin, Sivaraman, Hariharan, Sivaraman, J.

“…The 2019 coronavirus pandemic remains a major public health concern. Neutralizing antibodies (nAbs) represent a cutting-edge antiviral strategy. We focus here…”
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Structural Basis of SARS-CoV-2- and SARS-CoV-Receptor Binding and Small-Molecule Blockers as Potential Therapeutics by Sivaraman, Hariharan, Er, Shi Yin, Choong, Yeu Khai, Gavor, Edem, Sivaraman, J

“…Over the past two decades, deadly coronaviruses, with the most recent being the severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) 2019…”
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Structural Understanding of Fungal Terpene Synthases for the Formation of Linear or Cyclic Terpene Products by T, Rehka, Sharma, Deepti, Lin, Fu, Choong, Yeu Khai, Lim, Chinchin, Jobichen, Chacko, Zhang, Congqiang

“…Terpene synthases (TPSs), known gatekeepers of terpenoid diversity, are the main targets for enzyme engineering attempts. To this end, we have determined the…”
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Influence of pH on the activity of thrombin-derived antimicrobial peptides by Holdbrook, Daniel A., Singh, Shalini, Choong, Yeu Khai, Petrlova, Jitka, Malmsten, Martin, Bond, Peter J., Verma, Navin Kumar, Schmidtchen, Artur, Saravanan, Rathi

“…The wound environment is characterized by physiological pH changes. Proteolysis of thrombin by wound-derived proteases, such as neutrophil elastase, generates…”
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A C-terminal peptide of TFPI-1 facilitates cytosolic delivery of nucleic acid cargo into mammalian cells by Fazil, Mobashar Hussain Urf Turabe, Chalasani, Madhavi Latha Somaraju, Choong, Yeu Khai, Schmidtchen, Artur, Verma, Navin Kumar, Saravanan, Rathi

“…Efficient intracellular nucleic acid delivery into mammalian cells remains a long-standing challenge owing to poor cell permeability and uptake of naked…”
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Structure of Aedes aegypti carboxypeptidase B1‐inhibitor complex uncover the disparity between mosquito and non‐mosquito insect carboxypeptidase inhibition mechanism by Gavor, Edem, Choong, Yeu Khai, Jobichen, Chacko, Mok, Yu Keung, Kini, R. Manjunatha, Sivaraman, J.

“…Metallocarboxypeptidases (MCPs) in the mosquito midgut play crucial roles in infection, as well as in mosquito dietary digestion, reproduction, and…”
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Identification of putative binding interface of PI(3,5)P2 lipid on rice black-streaked dwarf virus (RBSDV) P10 protein by Liu, Haoqiu, Peck, Xin Yi, Choong, Yeu Khai, Ng, Woei Shyuan, Engl, Wilfried, Raghuvamsi, Palur Venkata, Zhao, Ziqing Winston, Anand, Ganesh S., Zhou, Yijun, Sivaraman, J., Xu, Qiufang, Wong, Sek-Man

“…Rice black-streaked dwarf virus (RBSDV) is an important reovirus that infects both plants and its transmission vector small brown planthopper, causing severe…”
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Identification of putative binding interface of PI(3,5)P 2 lipid on rice black-streaked dwarf virus (RBSDV) P10 protein by Liu, Haoqiu, Peck, Xin Yi, Choong, Yeu Khai, Ng, Woei Shyuan, Engl, Wilfried, Raghuvamsi, Palur Venkata, Zhao, Ziqing Winston, Anand, Ganesh S, Zhou, Yijun, Sivaraman, J, Xu, Qiufang, Wong, Sek-Man

“…Rice black-streaked dwarf virus (RBSDV) is an important reovirus that infects both plants and its transmission vector small brown planthopper, causing severe…”
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Proteolytic signatures define unique thrombin-derived peptides present in human wound fluid in vivo by Saravanan, Rathi, Adav, Sunil S., Choong, Yeu Khai, van der Plas, Mariena J. A., Petrlova, Jitka, Kjellström, Sven, Sze, Siu Kwan, Schmidtchen, Artur

“…The disease burden of failing skin repair and non-healing ulcers is extensive. There is an unmet need for new diagnostic approaches to better predict healing…”
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Bacterioferritin nanocage structures uncover the biomineralization process in ferritins by Jobichen, Chacko, Ying Chong, Tan, Rattinam, Rajesh, Basak, Sandip, Srinivasan, Mahalashmi, Choong, Yeu Khai, Pandey, Kannu Priya, Ngoc, Tran Bich, Shi, Jian, Angayarkanni, Jayaraman, Sivaraman, J

“…Iron is an essential element involved in various metabolic processes. The ferritin family of proteins forms nanocage assembly and is involved in iron…”
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Structure of Aedes aegypti procarboxypeptidase B1 and its binding with Dengue virus for controlling infection by Gavor, Edem, Choong, Yeu Khai, Tulsian, Nikhil Kumar, Nayak, Digant, Idris, Fakhriedzwan, Sivaraman, Hariharan, Ting, Donald Heng Rong, Sylvie, Alonso, Mok, Yu Keung, Kini, R Manjunatha, Sivaraman, J

“…Metallocarboxypeptidases play critical roles in the development of mosquitoes and influence pathogen/parasite infection of the mosquito midgut. Here, we report…”
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Protective Action of Linear Polyethylenimine against Staphylococcus aureus Colonization and Exaggerated Inflammation in Vitro and in Vivo by Mayandi, Venkatesh, Sridhar, Sreepathy, Fazil, Mobashar Hussain Urf Turabe, Goh, Eunice Tze Leng, Htoon, Hla Myint, Orive, Gorka, Choong, Yeu Khai, Saravanan, Rathi, Beuerman, Roger W, Barkham, Timothy Mark Sebastian, Yang, Liang, Baskaran, Mani, Jhanji, Vishal, Loh, Xian Jun, Verma, Navin Kumar, Lakshminarayanan, Rajamani

“…Increased evolution of multidrug resistant pathogens necessitates the development of multifunctional antimicrobials. There is a perceived need for developing…”
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