Search Results - "Choong, I."

Hepatitis Delta Virus Kinetics under the Prenylation Inhibitor Lonafarnib Suggest HDV-Mediated Suppression of HBV Replication by Yurdaydin, C, Borochov, N, Kalkan, C, DebRoy, S, Karatayli, E, Haynes-Williams, V, Karatayli, S.C, Canini, L, Uprichard, S.L, Bozdayi, A. Mihat, Choong, I, Cory, D, Heller, T, Cotler, S, Idilman, R, Glenn, J.S, Dahari, H

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O118 : Optimizing the prenylation inhibitor lonafarnib using ritonavir boosting in patients with chronic delta hepatitis by Yurdaydin, C, Idilman, R, Choong, I, Kalkan, C, Keskin, O, Karakaya, M.F, Tuzun, A.E, Karatayli, E, Bozdayi, M, Cory, D, Glenn, J.S

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Dose-dependent decrease in hepatitis delta virus (HDV) RNA achieved with the oral prenylation inhibitor lonafarnib in a proof-of-concept, randomised, double-blinded, placebo-controlled study in patients with chronic HDV infection by Koh, C, Canini, L, Dahari, H, Cooper, S, Cory, D, Winters, M.A, Choong, I, Cotler, S.J, Kleiner, D.E, Yurdaydin, C, Heller, T, Glenn, J.S

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Combinatorial Target-Guided Ligand Assembly: Identification of Potent Subtype-Selective c-Src Inhibitors by Maly, D J, Choong, I C, Ellman, J A

“…A method for the rapid and efficient identification of ligands to biological targets is reported. The combinatorial method does not require structural or…”
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In situ assembly of enzyme inhibitors using extended tethering by Erlanson, Daniel A, O'Brien, Tom, Lam, Joni W, Wiesmann, Christian, Luong, Tinh N, Simmons, Robert L, DeLano, Warren L, Choong, Ingrid C, Burdett, Matthew T, Flanagan, W. Michael, Lee, Dennis, Gordon, Eric M

“…Cysteine aspartyl protease-3 (caspase-3) is a mediator of apoptosis and a therapeutic target for a wide range of diseases. Using a dynamic combinatorial…”
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Cerebral palsy in siblings caused by compound heterozygous mutations in the gene encoding protein C by FONG, CHOONG YI, MUMFORD, ANDREW D, LIKEMAN, MARCUS J, JARDINE, PHILIP E

“…We report two sisters with extensive bilateral periventricular haemorrhagic infarction (PVHI) causing cerebral palsy (CP). The older sister presented at 20…”
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Identification of Potent and Selective Small-Molecule Inhibitors of Caspase-3 through the Use of Extended Tethering and Structure-Based Drug Design by Choong, Ingrid C, Lew, Willard, Lee, Dennis, Pham, Phuongly, Burdett, Matthew T, Lam, Joni W, Wiesmann, Christian, Luong, Tinh N, Fahr, Bruce, DeLano, Warren L, McDowell, Robert S, Allen, Darin A, Erlanson, Daniel A, Gordon, Eric M, O'Brien, Tom

“…The design, synthesis, and in vitro activities of a series of potent and selective small-molecule inhibitors of caspase-3 are described. From extended…”
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Distribution of corticotropin-releasing-factor-like immunoreactivity in brainstem of two monkey species (Saimiri sciureus and Macaca fascicularis): an immunohistochemical study by Foote, S L, Cha, C I

“…Immunohistochemical methods were utilized to systematically map the distribution of corticotropin-releasing-factor-like immunoreactivity (CRF-LI) in the…”
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Isoniazid and Pulmonary Fibrosis by Chung, Chae, Park, Dong, Lee, Choong, Jung, Sung

“…To the Editor：The anti-tuberculosis （TB） therapy can cause various drug adverse effects including hepatotoxicity,nephrotoxicity and skin rash.[1,2] There are…”
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FRI-111 - Hepatitis Delta Virus Kinetics under the Prenylation Inhibitor Lonafarnib Suggest HDV-Mediated Suppression of HBV Replication by Yurdaydin, C., Borochov, N., Kalkan, C., DebRoy, S., Karatayli, E., Haynes-Williams, V., Karatayli, S.C., Canini, L., Uprichard, S.L., Bozdayi, A. Mihat, Choong, I., Cory, D., Heller, T., Cotler, S., Idilman, R., Glenn, J.S., Dahari, H.

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High level expression and simple purification of recombinant human granulocyte colony-stimulating factor in E. coli by Kang, Soo-Hyung, Park, Jang-Hyeon, Park, Choong-II, Lee, Se-Yong, Lee, Young-Ik

“…A human granulocyte colony-stimulating factor (hG-CSF) gene was synthesized and inserted into a trp expression vector for overexpression in E. coli. A strong…”
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Prolonged Prothrombin Time After Recombinant Activated Factor VII Therapy in Critically Bleeding Trauma Patients Is Associated With Adverse Outcomes by McMullin, Neil R., Wade, Charles E., Holcomb, John B., Nielsen, Tina G., Rossaint, Rolf, Riou, Bruno, Rizoli, Sandro B., Kluger, Yoram, Choong, Philip I. T., Warren, Brian, Tortella, Bartholomew J., Boffard, Kenneth D.

“…BACKGROUND:In trauma patients with significant hemorrhage, it is hypothesized that failure to normalize prothrombin time (PT) after recombinant activated…”
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Small-Molecule Inhibition of TNF-α by He, Molly M., Smith, Annemarie Stroustrup, Oslob, Johan D., Flanagan, William M., Braisted, Andrew C., Whitty, Adrian, Cancilla, Mark T., Wang, Jun, Lugovskoy, Alexey A., Yoburn, Josh C., Fung, Amy D., Farrington, Graham, Eldredge, John K., Day, Eric S., Cruz, Leslie A., Cachero, Teresa G., Miller, Stephan K., Friedman, Jessica E., Choong, Ingrid C., Cunningham, Brian C.

“…We have identified a small-molecule inhibitor of tumor necrosis factor α (TNF-α) that promotes subunit disassembly of this trimeric cytokine family member. The…”
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Immunohistochemical study on the distribution of glycogen synthase kinase 3 Delta a in the central nervous system of SOD1G93A transgenic mice by Chung, Yoon Hee, Joo, Kyeung Min, Kim, Dae Jin, Kim, Sung Su, Kim, Kyung Yong, Lee, Won Bok, Cha, Choong I K

“…Objective: To identify glycogen synthase kinase (GSK) 3 Delta *a expression in a mouse model of familial amyotrophic lateral sclerosis (ALS), we investigated…”
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Varying the spectral envelope of air-conditioning sounds to enhance indoor acoustic comfort by Jeon, Jin Yong, You, Jin, Jeong, Choong Il, Kim, Su Yeon, Jho, Moon Jae

“…Sounds of ceiling mounted air-conditioners were recorded at various conditions of classrooms, offices, and libraries. Sound quality was manipulated by varying…”
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SIAH1-induced p34SEI-1 polyubiquitination/degradation mediates p53 preferential vitamin C cytotoxicity by LEE, SOONDUCK, KIM, JINSUN, JUNG, SAMIL, LI, CHENGPING, YANG, YOUNG, KIM, KEUN IL, LIM, JONG-SEOK, KIM, YONGHWAN, CHEON, CHOONG-IL, LEE, MYEONG-SOK

“…Vitamin C is considered as an important anticancer therapeutic agent although this view is debatable. In this study, we introduce a physiological mechanism…”
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Age-related changes in glycogen synthase kinase 3β (GSK3β) immunoreactivity in the central nervous system of rats by Lee, Soo Joo, Chung, Yoon Hee, Joo, Kyeung Min, Lim, Heon Chang, Jeon, Gye Sun, Kim, Daejin, Lee, Won Bok, Kim, Yong Sik, Cha, Choong Ik

“…Although glycogen synthase kinase 3β (GSK3β) is emerging as a prominent drug target in the treatment of neurodegenerative diseases such as Alzheimer's disease…”
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Spatial and temporal distribution of pituitary adenylate cyclase activating polypeptide in gerbil global cerebral ischemia by Shin, Chung Min, Chung, Yoon Hee, Kim, Myeung Ju, Cha, Choong Ik

“…In the present study, we used immunohistochemistry to investigate the effects of transient global ischemia on pituitary adenylate cyclase activating…”
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Clinical evaluation of 3 types of Plate osteosynthesis for fixation of condylar neck fractures. Discussion by CHOI, Byung-Ho, YI, Choong-Kook, YOO, Jae-Ha, ALPERT, Brian

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Immunohistochemical study on the distribution of canonical transient receptor potential channels in rat basal ganglia by Chung, Yoon Hee, Kim, Daejin, Moon, Nam Joo, Oh, Chang Seok, Lee, Eunju, Shin, Dong Hoon, Kim, Sung Su, Lee, Won Bok, Lee, Jun-Young, Cha, Choong Ik

“…In the present study, we examined the localizations of canonical transient receptor potential channels (TRPCs) in rat basal ganglia. The dot-like staining…”
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