Search Results - "Choong, David Y H"

Mutation of the PIK3CA gene in ovarian and breast cancer by CAMPBELL, Ian G, RUSSELL, Sarah E, CHOONG, David Y. H, MONTGOMERY, Karen G, CIAVARELLA, Marianne L, HOOI, Christine S. F, CRISTIANO, Briony E, PEARSON, Richard B, PHILLIPS, Wayne A

“…Phosphatidylinositol 3'-kinases are lipid kinases with important roles in neoplasia. Recently, a very high frequency of somatic mutations in PIK3CA has been…”
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Exome sequencing identifies rare deleterious mutations in DNA repair genes FANCC and BLM as potential breast cancer susceptibility alleles by Thompson, Ella R, Doyle, Maria A, Ryland, Georgina L, Rowley, Simone M, Choong, David Y H, Tothill, Richard W, Thorne, Heather, Barnes, Daniel R, Li, Jason, Ellul, Jason, Philip, Gayle K, Antill, Yoland C, James, Paul A, Trainer, Alison H, Mitchell, Gillian, Campbell, Ian G

“…Despite intensive efforts using linkage and candidate gene approaches, the genetic etiology for the majority of families with a multi-generational breast…”
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High-Resolution Single Nucleotide Polymorphism Array Analysis of Epithelial Ovarian Cancer Reveals Numerous Microdeletions and Amplifications by GORRINGE, Kylie L, JACOBS, Sharoni, THOMPSON, Ella R, SRIDHAR, Anita, WEN QIU, CHOONG, David Y. H, CAMPBELL, Lan G

“…Purpose: Genetic changes in sporadic ovarian cancer are relatively poorly characterized compared with other tumor types. We have evaluated the use of…”
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Differential hypermethylation of SOCS genes in ovarian and breast carcinomas by SUTHERLAND, Kate D, LINDEMAN, Geoffrey J, CHOONG, David Y. H, WITTLIN, Sergio, BRENTZELL, Luci, PHILLIPS, Wayne, CAMPBELL, Ian G, VISVADER, Jane E

“…Suppressor of cytokine signaling (SOCS) proteins have emerged as critical attenuators of cytokine-mediated processes, suggesting a role in the suppression of…”
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MicroRNA genes and their target 3'-untranslated regions are infrequently somatically mutated in ovarian cancers by Ryland, Georgina L, Bearfoot, Jennifer L, Doyle, Maria A, Boyle, Samantha E, Choong, David Y H, Rowley, Simone M, Tothill, Richard W, Gorringe, Kylie L, Campbell, Ian G

“…MicroRNAs are key regulators of gene expression and have been shown to have altered expression in a variety of cancer types, including epithelial ovarian…”
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Frequent somatic mutations of GATA3 in non-BRCA1/BRCA2 familial breast tumors, but not in BRCA1-, BRCA2- or sporadic breast tumors by Arnold, Jeremy M, Choong, David Y. H, Thompson, Ella R, Waddell, Nic, Lindeman, Geoffrey J, Visvader, Jane E, Campbell, Ian G, Chenevix-Trench, Georgia

“…Heterozygous somatic mutations of the transcription factor, GATA-3, have recently been reported in approximately 5% breast of tumors unselected for family…”
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Analysis of KLLN as a high-penetrance breast cancer predisposition gene by Thompson, Ella R., Gorringe, Kylie L., Choong, David Y. H., Eccles, Diana M., Mitchell, Gillian, Campbell, Ian G.

“…KLLN is a p53 target gene with DNA binding function and represents a highly plausible candidate breast cancer predisposition gene. We screened for predisposing…”
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BARD1 variants are not associated with breast cancer risk in Australian familial breast cancer by Gorringe, Kylie L., Choong, David Y. H., Visvader, Jane E., Lindeman, Geoffrey J., Campbell, Ian G.

“…Several studies in various populations have suggested that non-synonymous BARD1 variants are associated with increased breast cancer risk. Using DHPLC analysis…”
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Loss of heterozygosity: what is it good for? by Ryland, Georgina L, Doyle, Maria A, Goode, David, Boyle, Samantha E, Choong, David Y H, Rowley, Simone M, Li, Jason, Bowtell, David D L, Tothill, Richard W, Campbell, Ian G, Gorringe, Kylie L

“…Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be involved in the somatic loss of wild-type alleles in many…”
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Analysis of the mitogen-activated protein kinase kinase 4 (MAP2K4) tumor suppressor gene in ovarian cancer by Davis, Sally J, Choong, David Y H, Ramakrishna, Manasa, Ryland, Georgina L, Campbell, Ian G, Gorringe, Kylie L

“…MAP2K4 is a putative tumor and metastasis suppressor gene frequently found to be deleted in various cancer types. We aimed to conduct a comprehensive analysis…”
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Breast cancer risk and the BRCA1 interacting protein CTIP by Gorringe, Kylie L., Choong, David Y. H., Lindeman, Geoffrey J., Visvader, Jane E., Campbell, Ian G.

“…Mutations in BRCA1 predispose to breast cancer. CTIP interacts with BRCA1 and so could also be associated with increased risk. We screened CTIP for germline…”
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Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients by Thompson, Ella R., Boyle, Samantha E., Johnson, Julie, Ryland, Georgina L., Sawyer, Sarah, Choong, David Y.H., kConFab, Chenevix-Trench, Georgia, Trainer, Alison H., Lindeman, Geoffrey J., Mitchell, Gillian, James, Paul A., Campbell, Ian G.

“…There is strong evidence that overtly inactivating mutations in RAD51C predispose to hereditary breast and ovarian cancer but the prevalence of such mutations,…”
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EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer by CLANCY, Jennifer L, HENDERSON, Michelle J, BRADY, Ged, OLOPADE, Olufunmilayo I, WOOLLATT, Erica, DAVIES, Michael J, SEGARA, Davendra, HACKER, Neville F, HENSHALL, Susan M, SUTHERLAND, Robert L, WATTS, Colin K. W, RUSSELL, Amanda J, ANDERSON, David W, BOVA, Ronaldo J, CAMPBELL, Ian G, CHOONG, David Y. H, MACDONALD, Graeme A, MANN, Graham J, NOLAN, Tania

“…EDD (E3 isolated by differential display), located at chromosome 8q22.3, is the human orthologue of the Drosophila melanogaster tumour suppressor gene…”
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Genetic and Epigenetic Analysis of the Putative Tumor Suppressor km23 in Primary Ovarian, Breast, and Colorectal Cancers by CAMPBELL, Ian G, PHILLIPS, Wayne A, CHOONG, David Y. H

“…Purpose: A very high frequency of somatic mutations in the transforming growth factor-β signaling component km23 has been reported in a small series of ovarian…”
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No association of the MDM2 SNP309 polymorphism with risk of breast or ovarian cancer by Campbell, Ian G, Eccles, Diana M, Choong, David Y.H.

“…A functional T to G germline polymorphism in the promoter region of MDM2 (SNP309) has been reported to profoundly accelerate tumor formation suggesting that it…”
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Genetic Analysis of Cancer-Implicated MicroRNA in Ovarian Cancer by BEARFOOT, Jennifer L, CHOONG, David Y. H, GORRINGE, Kylie L, CAMPBELL, Lan G

“…Purpose: There is accumulating evidence that microRNAs may function like classic tumor suppressor genes but little is known about their mechanism of…”
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Copy number analysis of ductal carcinoma in situ with and without recurrence by Gorringe, Kylie L, Hunter, Sally M, Pang, Jia-Min, Opeskin, Ken, Hill, Prue, Rowley, Simone M, Choong, David Y H, Thompson, Ella R, Dobrovic, Alexander, Fox, Stephen B, Mann, G Bruce, Campbell, Ian G

“…Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer and a frequent mammographic finding requiring treatment. Up to 25% of…”
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Transforming Growth Factor β Receptor 1 Polyalanine Polymorphism and Exon 5 Mutation Analysis in Breast and Ovarian Cancer by BAXTER, Simon W, CHOONG, David Y. H, ECCLES, Diana M, CAMPBELL, Ian G

“…The inactivation or altered expression of TGF-β receptors or other components of the TGF-β signaling pathway are common in many cancer types. A germ-line…”
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Genetic and epigenetic analysis of the TIMP-3 gene in ovarian cancer by Liu, Mira C.P, Choong, David Y.H, Hooi, Christine S.F, Williams, Louise H, Campbell, Ian G

“…Abstract Chromosome 22q shows a high frequency of loss of heterozygosity (LOH) in ovarian cancers suggesting the existence of one or more important tumor…”
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Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer by Pang, Jia-Min B, Savas, Peter, Fellowes, Andrew P, Mir Arnau, Gisela, Kader, Tanjina, Vedururu, Ravikiran, Hewitt, Chelsee, Takano, Elena A, Byrne, David J, Choong, David YH, Millar, Ewan KA, Lee, C Soon, O'Toole, Sandra A, Lakhani, Sunil R, Cummings, Margaret C, Mann, G Bruce, Campbell, Ian G, Dobrovic, Alexander, Loi, Sherene, Gorringe, Kylie L, Fox, Stephen B

“…The spectrum of genomic alterations in ductal carcinoma in situ (DCIS) is relatively unexplored, but is likely to provide useful insights into its biology, its…”
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