Search Results - "Choolani, Mahesh"

Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species by Guilliams, Martin, Dutertre, Charles-Antoine, Scott, Charlotte L., McGovern, Naomi, Sichien, Dorine, Chakarov, Svetoslav, Van Gassen, Sofie, Chen, Jinmiao, Poidinger, Michael, De Prijck, Sofie, Tavernier, Simon J., Low, Ivy, Irac, Sergio Erdal, Mattar, Citra Nurfarah, Sumatoh, Hermi Rizal, Low, Gillian Hui Ling, Chung, Tam John Kit, Chan, Dedrick Kok Hong, Tan, Ker Kan, Hon, Tony Lim Kiat, Fossum, Even, Bogen, Bjarne, Choolani, Mahesh, Chan, Jerry Kok Yen, Larbi, Anis, Luche, Hervé, Henri, Sandrine, Saeys, Yvan, Newell, Evan William, Lambrecht, Bart N., Malissen, Bernard, Ginhoux, Florent

“…Dendritic cells (DCs) are professional antigen-presenting cells that hold great therapeutic potential. Multiple DC subsets have been described, and it remains…”
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Microbial exposure during early human development primes fetal immune cells by Mishra, Archita, Lai, Ghee Chuan, Yao, Leong Jing, Aung, Thet Tun, Shental, Noam, Rotter-Maskowitz, Aviva, Shepherdson, Edwin, Singh, Gurmit Singh Naranjan, Pai, Rhea, Shanti, Adhika, Wong, Regina Men Men, Lee, Andrea, Khyriem, Costerwell, Dutertre, Charles Antoine, Chakarov, Svetoslav, Srinivasan, K.G., Shadan, Nurhidaya Binte, Zhang, Xiao-Meng, Khalilnezhad, Shabnam, Cottier, Fabien, Tan, Alrina Shin Min, Low, Gillian, Chen, Phyllis, Fan, Yiping, Hor, Pei Xiang, Lee, Avery Khoo May, Choolani, Mahesh, Vermijlen, David, Sharma, Ankur, Fuks, Garold, Straussman, Ravid, Pavelka, Norman, Malleret, Benoit, McGovern, Naomi, Albani, Salvatore, Chan, Jerry Kok Yen, Ginhoux, Florent

“…The human fetal immune system begins to develop early during gestation; however, factors responsible for fetal immune-priming remain elusive. We explored…”
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3D genome organization in the epithelial-mesenchymal transition spectrum by Pang, Qing You, Tan, Tuan Zea, Sundararajan, Vignesh, Chiu, Yi-Chia, Chee, Edward Yu Wing, Chung, Vin Yee, Choolani, Mahesh A, Huang, Ruby Yun-Ju

“…The plasticity along the epithelial-mesenchymal transition (EMT) spectrum has been shown to be regulated by various epigenetic repertoires. Emerging evidence…”
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Parents’ perceptions of antenatal educational programs: A meta-synthesis by Shorey, Shefaly, Loh, Doris Ngiuk Lan, Chan, Valerie, Chua, Crystal, Choolani, Mahesh A

“…BACKGROUNDContents and mode of delivery of antenatal educational programs differed considerably. Yet there is a lack of high-level evidence about the delivery…”
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Oocytes on ice: Exploring the advancements in elective egg freezing for women by Ong, Judith, Mathew, Joyce, Choolani, Mahesh, Wong, Peng Cheang

“…Female fecundity decreases significantly after the age of 32, and rapidly so after age 37. There is no treatment to prevent this decline. Furthermore,…”
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The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype-specific therapeutic target for ovarian cancer by Antony, Jane, Tan, Tuan Zea, Kelly, Zoe, Low, Jeffrey, Choolani, Mahesh, Recchi, Chiara, Gabra, Hani, Thiery, Jean Paul, Huang, Ruby Yun-Ju

“…Ovarian cancer is a complex disease with heterogeneity among the gene expression molecular subtypes (GEMS) between patients. Patients with tumors of a…”
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Rapid and sensitive detection of ovarian cancer biomarker using a portable single peak Raman detection method by Moothanchery, Mohesh, Perumal, Jayakumar, Mahyuddin, Aniza Puteri, Singh, Gurpreet, Choolani, Mahesh, Olivo, Malini

“…Raman spectroscopy (RS) is a widely used non-destructive technique for biosensing applications because of its ability to detect unique ‘fingerprint’ spectra of…”
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Mechanisms and evidence of vertical transmission of infections in pregnancy including SARS‐CoV‐2s by Mahyuddin, Aniza P., Kanneganti, Abhiram, Wong, Jeslyn J.L., Dimri, Pooja S., Su, Lin L., Biswas, Arijit, Illanes, Sebastian E., Mattar, Citra N. Z., Huang, Ruby Y.‐J., Choolani, Mahesh

“…There remain unanswered questions concerning mother‐to‐child‐transmission of SARS‐CoV‐2. Despite reports of neonatal COVID‐19, SARS‐CoV‐2 has not been…”
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Third-Generation Single-Molecule Sequencing for Preimplantation Genetic Testing of Aneuploidy and Segmental Imbalances by Tan, Vivienne J, Liu, Timing, Arifin, Zainul, Pak, Beatrice, Tan, Arnold S C, Wong, Simin, Khor, Chiea-Chuen, Yang, Henry, Lee, Caroline G, Huang, Zhongwei, Choolani, Mahesh A, Chong, Samuel S

“…Abstract Background Current strategies for preimplantation genetic testing for aneuploidy or structural rearrangements (PGT-A/SR) rely mainly on…”
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Unravelling the mystery of stem/progenitor cells in human breast milk by Fan, Yiping, Chong, Yap Seng, Choolani, Mahesh A, Cregan, Mark D, Chan, Jerry K Y

“…Mammary stem cells have been extensively studied as a system to delineate the pathogenesis and treatment of breast cancer. However, research on mammary stem…”
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microRNA‐200b modulates microglia‐mediated neuroinflammation via the cJun/MAPK pathway by Jadhav, Shweta P., Kamath, Sandhya P., Choolani, Mahesh, Lu, Jia, Dheen, S. Thameem

“…Chronic activation of microglia, the macrophages of the CNS, has been shown to enhance neuronal damage because of excessive release of proinflammatory…”
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Superior Osteogenic Capacity for Bone Tissue Engineering of Fetal Compared with Perinatal and Adult Mesenchymal Stem Cells by Zhang, Zhi‐Yong, Teoh, Swee‐Hin, Chong, Mark S.K., Schantz, Jan Thorsten, Fisk, Nicholas M., Choolani, Mahesh A., Chan, Jerry

“…Mesenchymal stem cells (MSCs) from human adult bone marrow (haMSCs) represent a promising source for bone tissue engineering. However, their low frequencies…”
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Parents' Perceptions of Their Parenting Journeys and a Mobile App Intervention (Parentbot-A Digital Healthcare Assistant): Qualitative Process Evaluation by Chua, Joelle Yan Xin, Choolani, Mahesh, Chee, Cornelia Yin Ing, Yi, Huso, Chan, Yiong Huak, Lalor, Joan Gabrielle, Chong, Yap Seng, Shorey, Shefaly

“…Parents experience many challenges during the perinatal period. Mobile app-based interventions and chatbots show promise in delivering health care support for…”
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Mesenchymal Stem Cells-Induced Trophoblast Invasion Is Reduced in Patients with a Previous History of Preeclampsia by Peñailillo, Reyna, Acuña-Gallardo, Stephanie, García, Felipe, Monteiro, Lara J., Nardocci, Gino, Choolani, Mahesh A., Kemp, Matthew W., Romero, Roberto, Illanes, Sebastián E.

“…Endometrial stromal cells play an important role in reproductive success, especially in implantation and placentation. Although Mesenchymal stem cells (MSCs)…”
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The potential of human fetal mesenchymal stem cells for off-the-shelf bone tissue engineering application by Zhang, Zhi-Yong, Teoh, Swee-Hin, Hui, James H.P, Fisk, Nicholas M, Choolani, Mahesh, Chan, Jerry K.Y

“…Abstract Mesenchymal stem cells (MSCs) have become one of the most promising cell sources for bone tissue engineering (BTE) applications. In this review, we…”
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Integration-free induced pluripotent stem cells from three endangered Southeast Asian non-human primate species by Bao, Qiuye, Tay, Nicole Liling, Lim, Christina Yingyan, Chua, Delia Hwee Hoon, Kee, Su Keyau, Choolani, Mahesh, Loh, Yuin-Han, Ng, Soon Chye, Chai, Chou

“…Advanced molecular and cellular technologies provide promising tools for wildlife and biodiversity conservation. Induced pluripotent stem cell (iPSC)…”
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Pre‐ and Postnatal Transplantation of Fetal Mesenchymal Stem Cells in Osteogenesis Imperfecta: A Two‐Center Experience by Götherström, Cecilia, Westgren, Magnus, Shaw, S.W. Steven, Åström, Eva, Biswas, Arijit, Byers, Peter H., Mattar, Citra N.Z., Graham, Gail E., Taslimi, Jahan, Ewald, Uwe, Fisk, Nicholas M., Yeoh, Allen E.J., Lin, Ju-Li, Cheng, Po-Jen, Choolani, Mahesh, Le Blanc, Katarina, Chan, Jerry K.Y.

“…This study reports the clinical course of two patients with osteogenesis imperfecta who received prenatal human fetal mesenchymal stem cell (MSC)…”
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Upregulation of hepatic nuclear receptors in extremely preterm ovine fetuses undergoing artificial placenta therapy by Ikeda, Hideyuki, Watanabe, Shimpei, Sato, Shinichi, Fee, Erin L, Carter, Sean W D, Kumagai, Yusaku, Takahashi, Tsukasa, Kawamura, Shinichi, Hanita, Takushi, Illanes, Sebastian E, Choolani, Mahesh A, Saito, Masatoshi, Kikuchi, Atsuo, Kemp, Matthew W, Usuda, Haruo

“…Extremely preterm infants have low Nuclear Receptor (NR) expression in their developing hepatobiliary systems, as they rely on the placenta and maternal liver…”
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Therapeutic expression of human clotting factors IX and × following adeno‐associated viral vector‐mediated intrauterine gene transfer in early‐gestation fetal macaques by Chan, Jerry K. Y., Gil-Farina, Irene, Johana, Nuryanti, Rosales, Cecilia, Tan, Yi Wan, Ceiler, Jessika, Mcintosh, Jenny, Ogden, Bryan, Waddington, Simon N., Schmidt, Manfred, Biswas, Arijit, Choolani, Mahesh, Nathwani, Amit C., Mattar, Citra N. Z.

“…ABSTRACT Adeno‐associated viral vectors (AAVs) achieve stable therapeutic expression without long‐term toxicity in adults with hemophilia. To avert…”
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LPCAT1 levels in the placenta, the maternal plasma and the fetal plasma do not predict fetal lung responses to glucocorticoids in a sheep model of pregnancy by Takahashi, Tsukasa, Fee, Erin L., Takahashi, Yuki, Usuda, Haruo, Carter, Sean W.D., Ikeda, Hideyuki, Saito, Masatoshi, Kumagai, Yusaku, Bridges, James P., Jobe, Alan H., Choolani, Mahesh A., Kemp, Matthew W.

“…Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is important for saturated phosphatidylcholine (Sat-PC) production in the lung. Sat-PC is a critical…”
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