Search Results - "Choo, K. H. Andy"

PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells by Chang, Fiona T M, McGhie, James D, Chan, F Lyn, Tang, Michelle C, Anderson, Melissa A, Mann, Jeffrey R, Andy Choo, K H, Wong, Lee H

“…We have previously shown that α-thalassemia mental retardation X-linked (ATRX) and histone H3.3 are key regulators of telomeric chromatin in mouse embryonic…”
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The evolutionary life cycle of the resilient centromere by Kalitsis, Paul, Choo, K. H. Andy

“…The centromere is a chromosomal structure that is essential for the accurate segregation of replicated eukaryotic chromosomes to daughter cells. In most…”
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LINE retrotransposon RNA is an essential structural and functional epigenetic component of a core neocentromeric chromatin by Chueh, Anderly C, Northrop, Emma L, Brettingham-Moore, Kate H, Choo, K H Andy, Wong, Lee H

“…We have previously identified and characterized the phenomenon of ectopic human centromeres, known as neocentromeres. Human neocentromeres form epigenetically…”
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Active transcription and essential role of RNA polymerase II at the centromere during mitosis by Chan, F. Lyn, Marshall, Owen J, Saffery, Richard, Won Kim, Bo, Earle, Elizabeth, Choo, K. H. Andy, Wong, Lee H

“…Transcription of the centromeric regions has been reported to occur in G1 and S phase in different species. Here, we investigate whether transcription also…”
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Epigenetic Changes in Response to Tai Chi Practice: A Pilot Investigation of DNA Methylation Marks by Andy Choo, K. H., Clay, Fiona, Lam, Paul, Han, Jin-Song, Clarke, Sandy J., Collins, Veronica, Ren, Hua, Williamson, Lara M.

“…Tai chi exercise has been shown to improve physiological and psychosocial functions, well-being, quality of life, and disease conditions. The biological…”
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Permissive transcriptional activity at the centromere through pockets of DNA hypomethylation by Wong, Nicholas C, Wong, Lee H, Quach, Julie M, Canham, Paul, Craig, Jeffrey M, Song, Jenny Z, Clark, Susan J, Choo, K H Andy

“…DNA methylation is a hallmark of transcriptional silencing, yet transcription has been reported at the centromere. To address this apparent paradox, we…”
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Normal DNA methylation dynamics in DICER1-deficient mouse embryonic stem cells by Ip, Jonathan, Canham, Paul, Choo, K H Andy, Inaba, Yoshimi, Jacobs, Shelley A, Kalitsis, Paul, Mattiske, Deidre M, Ng, Jane, Saffery, Richard, Wong, Nicholas C, Wong, Lee H, Mann, Jeffrey R

“…Reduced DNA methylation has been reported in DICER1-deficient mouse ES cells. Reductions seen at pericentric satellite repeats have suggested that siRNAs are…”
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Neocentromeres: Role in Human Disease, Evolution, and Centromere Study by Amor, David J., Choo, K.H. Andy

“…The centromere is essential for the proper segregation and inheritance of genetic information. Neocentromeres are ectopic centromeres that originate…”
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Human Centromere Repositioning "In Progress" by Amor, David J., Bentley, Karen, Ryan, Jacinta, Perry, Jo, Wong, Lee, Slater, Howard, K. H. Andy Choo, Kunkel, Louis M.

“…Centromere repositioning provides a potentially powerful evolutionary force for reproductive isolation and speciation, but the underlying mechanisms remain…”
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Mouse Telocentric Sequences Reveal a High Rate of Homogenization and Possible Role in Robertsonian Translocation by Kalitsis, Paul, Griffiths, Belinda, Choo, K. H. Andy

“…The telomere and centromere are two specialized structures of eukaryotic chromosomes that are essential for chromosome stability and segregation. These…”
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Three-dimensional localization of CENP-A suggests a complex higher order structure of centromeric chromatin by Marshall, Owen J, Marshall, Alan T, Choo, K.H. Andy

“…The histone H3 variant centromere protein A (CENP-A) is central to centromere formation throughout eukaryotes. A long-standing question in centromere biology…”
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Putative CENP-B paralogues are not present at mammalian centromeres by Marshall, Owen J, Choo, K. H. Andy

“…Although centromere protein B (CENP-B) is a highly conserved mammalian centromere protein, its function remains unknown. The presence of the protein is…”
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Centromere Proteins Cenpa, Cenpb, and Bub3 Interact with Poly(ADP-ribose) Polymerase-1 Protein and Are Poly(ADP-ribosyl)ated by Saxena, Alka, Saffery, Richard, Wong, Lee H., Kalitsis, Paul, Choo, K. H. Andy

“…Poly(ADP-ribose) polymerase-1 (PARP-1) is activated by DNA strand breaks during cellular genotoxic stress response and catalyzes poly(ADP-ribosyl)ation of…”
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Shorter Telomere Length in Peripheral Blood Cells Associated With Migraine in Women by Ren, Hua, Collins, Veronica, Fernandez, Francesca, Quinlan, Sharon, Griffiths, Lyn, Choo, K. H. Andy

“…(Headache 2010;50:965‐972) Objective.— To evaluate relative telomere length of female migraine patients. Background.— Migraine is a debilitating disorder…”
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ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells by Wong, Lee H, McGhie, James D, Sim, Marcus, Anderson, Melissa A, Ahn, Soyeon, Hannan, Ross D, George, Amee J, Morgan, Kylie A, Mann, Jeffrey R, Choo, K H Andy

“…ATRX (alpha thalassemia/mental retardation syndrome X-linked) belongs to the SWI2/SNF2 family of chromatin remodeling proteins. Besides the ATPase/helicase…”
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Neocentromeres come of age by Marshall, Owen J, Choo, K H Andy

“…  Whereas previously centromeres had been thought of as immovable and unchanging, embedded in vast tracts of tandemly repeated DNA, this new centromere--or…”
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High-throughput analysis of chromosome abnormality in spontaneous miscarriage using an MLPA subtelomere assay with an ancillary FISH test for polyploidy by Bruno, Damien L., Burgess, Trent, Ren, Hua, Nouri, Sara, Pertile, Mark D., Francis, David I., Norris, Fiona, Kenney, Bronwyn K., Schouten, Jan, Andy Choo, K.H., Slater, Howard R.

“…Chromosome analysis of spontaneous miscarriages is clinically important but is hampered by frequent tissue culture failure and relatively low‐resolution…”
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Contrasting roles of condensin I and condensin II in mitotic chromosome formation by Green, Lydia C, Kalitsis, Paul, Chang, Tsz M, Cipetic, Miri, Kim, Ji Hun, Marshall, Owen, Turnbull, Lynne, Whitchurch, Cynthia B, Vagnarelli, Paola, Samejima, Kumiko, Earnshaw, William C, Choo, K H Andy, Hudson, Damien F

“…In vertebrates, two condensin complexes exist, condensin I and condensin II, which have differing but unresolved roles in organizing mitotic chromosomes. To…”
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A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA by Sart, Desirée du, Saffery, Richard, Barry, Alyssa E, Kalitsis, Paul, Cancilla, Michael R, Tainton, Kellie M, Martyn, John, Choo, K. H. Andy, Mao, Jen-i, Earle, Elizabeth

“…We recently described a human marker chromosome containing a functional neo-centromere that binds anti-centromere antibodies, but is devoid of centromeric…”
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Neocentromeres: New Insights into Centromere Structure, Disease Development, and Karyotype Evolution by Marshall, Owen J., Chueh, Anderly C., Wong, Lee H., Choo, K.H. Andy

“…Since the discovery of the first human neocentromere in 1993, these spontaneous, ectopic centromeres have been shown to be an astonishing example of epigenetic…”
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