Search Results - "Chong, Zhenlu"

A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome by Deng, Zimu, Chong, Zhenlu, Law, Christopher S, Mukai, Kojiro, Ho, Frances O, Martinu, Tereza, Backes, Bradley J, Eckalbar, Walter L, Taguchi, Tomohiko, Shum, Anthony K

“…Pathogenic COPA variants cause a Mendelian syndrome of immune dysregulation with elevated type I interferon signaling. COPA is a subunit of coat protein…”
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Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection by Winkler, Emma S., Gilchuk, Pavlo, Yu, Jinsheng, Bailey, Adam L., Chen, Rita E., Chong, Zhenlu, Zost, Seth J., Jang, Hyesun, Huang, Ying, Allen, James D., Case, James Brett, Sutton, Rachel E., Carnahan, Robert H., Darling, Tamarand L., Boon, Adrianus C.M., Mack, Matthias, Head, Richard D., Ross, Ted M., Crowe, James E., Diamond, Michael S.

“…SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered neutralizing antibodies against SARS-CoV-2 show promise in clinical trials,…”
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Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains by Case, James Brett, Mackin, Samantha, Errico, John M., Chong, Zhenlu, Madden, Emily A., Whitener, Bradley, Guarino, Barbara, Schmid, Michael A., Rosenthal, Kim, Ren, Kuishu, Dang, Ha V., Snell, Gyorgy, Jung, Ana, Droit, Lindsay, Handley, Scott A., Halfmann, Peter J., Kawaoka, Yoshihiro, Crowe, James E., Fremont, Daved H., Virgin, Herbert W., Loo, Yueh-Ming, Esser, Mark T., Purcell, Lisa A., Corti, Davide, Diamond, Michael S.

“…Omicron variant strains encode large numbers of changes in the spike protein compared to historical SARS-CoV-2 isolates. Although in vitro studies have…”
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E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses by Song, Yinjing, Lai, Lihua, Chong, Zhenlu, He, Jia, Zhang, Yuanyuan, Xue, Yue, Xie, Yiwei, Chen, Songchang, Dong, Ping, Chen, Luoquan, Chen, Zhimin, Dai, Feng, Wan, Xiaopeng, Xiao, Peng, Cao, Xuetao, Liu, Yang, Wang, Qingqing

“…Viruses can escape from host recognition by degradation of RIG-I or interference with the RIG-I signalling to establish persistent infections. However, the…”
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An immunostimulatory glycolipid that blocks SARS-CoV-2, RSV, and influenza infections in vivo by Tsuji, Moriya, Nair, Manoj S., Masuda, Kazuya, Castagna, Candace, Chong, Zhenlu, Darling, Tamarand L., Seehra, Kuljeet, Hwang, Youngmin, Ribeiro, Ágata Lopes, Ferreira, Geovane Marques, Corredor, Laura, Coelho-dos-Reis, Jordana Grazziela Alves, Tsuji, Yukiko, Mori, Munemasa, Boon, Adrianus C. M., Diamond, Michael S., Huang, Yaoxing, Ho, David D.

“…Prophylactic vaccines for SARS-CoV-2 have lowered the incidence of severe COVID-19, but emergence of viral variants that are antigenically distinct from the…”
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The VLDLR entry receptor is required for the pathogenesis of multiple encephalitic alphaviruses by Palakurty, Sathvik, Raju, Saravanan, Sariol, Alan, Chong, Zhenlu, Wagoner, Ngan, Ma, Hongming, Zimmerman, Ofer, Adams, Lucas J., Carmona, Camille, Liu, Zhuoming, Fremont, Daved H., Whelan, Sean P.J., Klimstra, William B., Diamond, Michael S.

“…The very-low-density lipoprotein receptor (VLDLR) has been reported as an entry receptor for Semliki Forest (SFV) and Eastern equine encephalitis (EEEV)…”
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Evaluation of efficacy, biodistribution and safety of antibiotic-free plasmid encoding somatostatin genes delivered by attenuated Salmonella enterica serovar Choleraesuis by Liang, Aixin, Riaz, Hasan, Dong, Fangxiao, Luo, Xuan, Yu, Xue, Han, Yanguo, Chong, Zhenlu, Han, Li, Guo, Aizhen, Yang, Liguo

“…Highlights • Asd-based balanced-lethal system for DNA vaccine was evaluated in this paper. • The C501(pVGS/2SS-asd) vaccine could induce systemic and mucosal…”
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Somatostatin and its receptors: Functional regulation in the development of mice Sertoli cells by Riaz, Hasan, Liang, Aixin, Khan, Muhammad Kasib, Dong, Ping, Han, Li, Shahzad, Muhammad, Chong, Zhenlu, Ahmad, Sibtain, Hua, Guohua, Yang, Liguo

“…•Mice Sertoli cells expressed all somatostatin receptors.•Somatostatin receptor subtype 2 and 5 are important during Sertoli cell developmental period.•SRIF14…”
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The gastrointestinal tract-restricted helminth H. polygyrus bakeri protects against SARS-CoV-2-induced lung disease in mice by Karl, Courtney, Desai, Pritesh, Liu, Meizi, Mackin, Samantha, Chong, Zhenlu, Yu, Jinsheng, Thackray, Larissa, Diamond, Michael

“…Abstract Helminth-virus coinfection models can provide valuable insights into the regulation and modulation of host antiviral immunity. Epidemiological…”
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Boosting with variant-matched or historical mRNA vaccines protects against Omicron infection in mice by Ying, Baoling, Scheaffer, Suzanne M., Whitener, Bradley, Liang, Chieh-Yu, Dmytrenko, Oleksandr, Mackin, Samantha, Wu, Kai, Lee, Diana, Avena, Laura E., Chong, Zhenlu, Case, James Brett, Ma, LingZhi, Kim, Thu T.M., Sein, Caralyn E., Woods, Angela, Berrueta, Daniela Montes, Chang, Gwo-Yu, Stewart-Jones, Guillaume, Renzi, Isabella, Lai, Yen-Ting, Malinowski, Agata, Carfi, Andrea, Elbashir, Sayda M., Edwards, Darin K., Thackray, Larissa B., Diamond, Michael S.

“…The large number of spike substitutions in Omicron lineage variants (BA.1, BA.1.1., and BA.2) could jeopardize the efficacy of SARS-CoV-2 vaccines. We…”
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Nasally delivered interferon-λ protects mice against infection by SARS-CoV-2 variants including Omicron by Chong, Zhenlu, Karl, Courtney E., Halfmann, Peter J., Kawaoka, Yoshihiro, Winkler, Emma S., Keeler, Shamus P., Holtzman, Michael J., Yu, Jinsheng, Diamond, Michael S.

“…Although vaccines and monoclonal antibody countermeasures have reduced the morbidity and mortality associated with severe acute respiratory syndrome…”
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A non-canonical mechanism of antiviral activity of Oligoadenylate Synthetase 1 by Harioudh, Munesh, Perez, Joseph, Chong, Zhenlu, Nair, Sharmila, So, Lomon, McCormick, Kevin, Ghosh, Arundhati, Shao, Lulu, Srivastava, Rashmi, Soveg, Frank, Ebert, Thomas, Atianand, Maninjay, Hornung, Veit, Savan, Ram, Diamond, Michael, Sarkar, Saumendra

“…Abstract The translational arrest of protein synthesis is often a cellular response to the virus infection. However, some antiviral proteins continue to be…”
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Disruption of follistatin by RNAi increases apoptosis, arrests S-phase of cell cycle and decreases estradiol production in bovine granulosa cells by Chong, Zhenlu, Dong, Ping, Riaz, Hasan, Shi, Lei, Yu, Xue, Cheng, Ying, Yang, Liguo

“…•Knockdown of FST arrested granulosa cells at S-phase cell cycle.•Follistatin may participate in caspase3-dependent apoptosis through Bcl2/Bax gene…”
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Identification and IVC of spermatogonial stem cells in prepubertal buffaloes by Yu, Xue, Riaz, Hasan, Dong, Ping, Chong, Zhenlu, Luo, Xuan, Liang, Aixin, Yang, Liguo

“…Development of suitable selective marker for buffalo spermatogonial stem cells (SSCs), optimization of long-term IVC conditions, and their pluripotent…”
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E3 ligase FBXW7 aggravates TMPD-induced systemic lupus erythematosus by promoting cell apoptosis by Chong, Zhenlu, Bao, Chunjing, He, Jia, Chen, Tianxiao, Zhong, Lijia, Li, Gaopeng, Li, Huanle, Fang, Lutong, Song, Yinjing, Fu, Guoxiang, Yang, Xuyan, Lai, Lihua, Liu, Yang, Wang, Qingqing

“…Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, and the pathogenesis of SLE has not been fully elucidated. The E3 ubiquitin ligase FBXW7…”
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A broadly reactive antibody targeting the N-terminal domain of SARS-CoV-2 spike confers Fc-mediated protection by Adams, Lucas J, VanBlargan, Laura A, Liu, Zhuoming, Gilchuk, Pavlo, Zhao, Haiyan, Chen, Rita E, Raju, Saravanan, Chong, Zhenlu, Whitener, Bradley M, Shrihari, Swathi, Jethva, Prashant N, Gross, Michael L, Crowe, Jr, James E, Whelan, Sean P J, Diamond, Michael S, Fremont, Daved H

“…Most neutralizing anti-SARS-CoV-2 monoclonal antibodies (mAbs) target the receptor binding domain (RBD) of the spike (S) protein. Here, we characterize a panel…”
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Evaluation of efficacy, biodistribution and safety of antibiotic-free plasmid encoding somatostatin genes delivered by attenuatedSalmonella entericaserovar Choleraesuis by Liang, Aixin, Riaz, Hasan, Dong, Fangxiao, Luo, Xuan, Yu, Xue, Han, Yanguo, Chong, Zhenlu, Han, Li, Guo, Aizhen, Yang, Liguo

“…We describe here a balanced-lethal system using an Asd+expression plasmid pVGS/2SS-asd encoding two copies of somatostatin (SS) genes carried by δasd/δcrp…”
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