Search Results - "Chong, Toh Han"

Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma by Nguyen, Phuong H. D., Ma, Siming, Phua, Cheryl Z. J., Kaya, Neslihan A., Lai, Hannah L. H., Lim, Chun Jye, Lim, Jia Qi, Wasser, Martin, Lai, Liyun, Tam, Wai Leong, Lim, Tony K. H., Wan, Wei Keat, Loh, Tracy, Leow, Wei Qiang, Pang, Yin Huei, Chan, Chung Yip, Lee, Ser Yee, Cheow, Peng Chung, Toh, Han Chong, Ginhoux, Florent, Iyer, Shridhar, Kow, Alfred W. C., Young Dan, Yock, Chung, Alexander, Bonney, Glen K., Goh, Brian K. P., Albani, Salvatore, Chow, Pierce K. H., Zhai, Weiwei, Chew, Valerie

“…The clinical relevance of immune landscape intratumoural heterogeneity (immune-ITH) and its role in tumour evolution remain largely unexplored. Here, we…”
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Trajectory of immune evasion and cancer progression in hepatocellular carcinoma by Nguyen, Phuong H. D., Wasser, Martin, Tan, Chong Teik, Lim, Chun Jye, Lai, Hannah L. H., Seow, Justine Jia Wen, DasGupta, Ramanuj, Phua, Cheryl Z. J., Ma, Siming, Yang, Jicheng, Suthen, Sheena D/O, Tam, Wai Leong, Lim, Tony K. H., Yeong, Joe, Leow, Wei Qiang, Pang, Yin Huei, Soon, Gwyneth, Loh, Tracy Jiezhen, Wan, Wei Keat, Chan, Chung Yip, Cheow, Peng Chung, Toh, Han Chong, Kow, Alfred, Dan, Yock Young, Kam, Juinn Huar, Iyer, Shridhar, Madhavan, Krishnakumar, Chung, Alexander, Bonney, Glenn K., Goh, Brian K. P., Fu, Naiyang, Yu, Victor C., Zhai, Weiwei, Albani, Salvatore, Chow, Pierce K. H., Chew, Valerie

“…Immune evasion is key to cancer initiation and later at metastasis, but its dynamics at intermediate stages, where potential therapeutic interventions could be…”
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Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms by Tay, Rong En, Richardson, Emma K., Toh, Han Chong

“…Cancer immunotherapy has revolutionised cancer treatment, with immune checkpoint blockade (ICB) therapy and adoptive cell therapy (ACT) increasingly becoming…”
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Awakening immunity against cancer:a 2017 primer for clinicians by Jain, Amit, Zhang, Qing, Toh, Han-Chong

“…Cancer immunotherapy has finally joined the pillars of cancer treatment—surgery, radiation, chemotherapy, hormonal therapy, and targeted therapy—in improving…”
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In-situ scalable manufacturing of Epstein–Barr virus-specific T-cells using bioreactor with an expandable culture area (BECA) by Chen, Sixun, Bin Abdul Rahim, Ahmad Amirul, Wang, Who-Whong, Cheong, Rachael, Prabhu, Akshaya V., Tan, Jerome Zu Yao, Naing, May Win, Toh, Han Chong, Liu, Dan

“…The ex-vivo expansion of antigen-specific T-cells for adoptive T-cell immunotherapy requires active interaction between T-cells and antigen-presenting cells…”
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The utility of Aspirin in Dukes C and High Risk Dukes B Colorectal cancer--the ASCOLT study: study protocol for a randomized controlled trial by Ali, Raghib, Toh, Han-Chong, Chia, Whay-Kuang

“…High quality evidence indicates that aspirin is effective in reducing colorectal polyps; and numerous epidemiological studies point towards an ability to…”
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Author Correction: Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma by Nguyen, Phuong H. D., Ma, Siming, Phua, Cheryl Z. J., Kaya, Neslihan A., Lai, Hannah L. H., Lim, Chun Jye, Lim, Jia Qi, Wasser, Martin, Lai, Liyun, Tam, Wai Leong, Lim, Tony K. H., Wan, Wei Keat, Loh, Tracy, Leow, Wei Qiang, Pang, Yin Huei, Chan, Chung Yip, Lee, Ser Yee, Cheow, Peng Chung, Toh, Han Chong, Ginhoux, Florent, Iyer, Shridhar, Kow, Alfred W. C., Young Dan, Yock, Chung, Alexander, Bonney, Glen K., Goh, Brian K. P., Albani, Salvatore, Chow, Pierce K. H., Zhai, Weiwei, Chew, Valerie

“…A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21556-y…”
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Cost-effectiveness of aspirin adjuvant therapy in early stage colorectal cancer in older patients by Soon, Swee Sung, Chia, Whay-Kuang, Chan, Mun-ling Sarah, Ho, Gwo Fuang, Jian, Xiao, Deng, Yan Hong, Tan, Chuen-Seng, Sharma, Atul, Segelov, Eva, Mehta, Shaesta, Ali, Raghib, Toh, Han-Chong, Wee, Hwee-Lin

“…Recent observational studies showed that post-operative aspirin use reduces cancer relapse and death in the earliest stages of colorectal cancer. We sought to…”
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Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma by Lim, Chun Jye, Lee, Yun Hua, Pan, Lu, Lai, Liyun, Chua, Camillus, Wasser, Martin, Lim, Tony Kiat Hon, Yeong, Joe, Toh, Han Chong, Lee, Ser Yee, Chan, Chung Yip, Goh, Brian Kp, Chung, Alexander, Heikenwälder, Mathias, Ng, Irene Ol, Chow, Pierce, Albani, Salvatore, Chew, Valerie

“…Chronic inflammation induced by chronic hepatitis B virus (HBV) infection increases the risk of hepatocellular carcinoma (HCC). However, little is known about…”
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Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression by Ericksen, Russell E., Lim, Siew Lan, McDonnell, Eoin, Shuen, Wai Ho, Vadiveloo, Maya, White, Phillip J., Ding, Zhaobing, Kwok, Royston, Lee, Philip, Radda, George K., Toh, Han Chong, Hirschey, Matthew D., Han, Weiping

“…Tumors display profound changes in cellular metabolism, yet how these changes aid the development and growth of tumors is not fully understood. Here we use a…”
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Linifanib versus Sorafenib in patients with advanced hepatocellular carcinoma: results of a randomized phase III trial by Cainap, Calin, Qin, Shukui, Huang, Wen-Tsung, Chung, Ik Joo, Pan, Hongming, Cheng, Ying, Kudo, Masatoshi, Kang, Yoon-Koo, Chen, Pei-Jer, Toh, Han-Chong, Gorbunova, Vera, Eskens, Ferry A L M, Qian, Jiang, McKee, Mark D, Ricker, Justin L, Carlson, Dawn M, El-Nowiem, Saied

“…This open-label phase III trial evaluated efficacy and tolerability of linifanib versus sorafenib in patients with advanced hepatocellular carcinoma (HCC)…”
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Personalised medicine in nasopharyngeal cancer by Toh, Han Chong, Ha, Tam Cam, Wee, Joseph

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Aspirin as adjuvant therapy for colorectal cancer—reinterpreting paradigms by Chia, Whay Kuang, Ali, Raghib, Toh, Han Chong

“…Aspirin has been widely reported to be associated with cancer prevention, and now its use as a cancer therapy option is being explored. In this Review, the…”
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Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy by Zhao, Yue, Shuen, Timothy Wai Ho, Toh, Tan Boon, Chan, Xue Ying, Liu, Min, Tan, Sue Yee, Fan, Yong, Yang, Hechuan, Lyer, Shridhar Ganpathi, Bonney, Glenn Kunnath, Loh, Eva, Chang, Kenneth Tou En, Tan, Thiam Chye, Zhai, Weiwei, Chan, Jerry Kok Yen, Chow, Edward Kai-Hua, Chee, Cheng Ean, Lee, Guan Huei, Dan, Yock Young, Chow, Pierce Kah-Hoe, Toh, Han Chong, Lim, Seng Gee, Chen, Qingfeng

“…As the current therapeutic strategies for human hepatocellular carcinoma (HCC) have been proven to have limited effectiveness, immunotherapy becomes a…”
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A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets by Deng, Niantao, Goh, Liang Kee, Wang, Hannah, Das, Kakoli, Tao, Jiong, Tan, Iain Beehuat, Zhang, Shenli, Lee, Minghui, Wu, Jeanie, Lim, Kiat Hon, Lei, Zhengdeng, Goh, Glenn, Lim, Qing-Yan, Tan, Angie Lay-Keng, Sin Poh, Dianne Yu, Riahi, Sudep, Bell, Sandra, Shi, Michael M, Linnartz, Ronald, Zhu, Feng, Yeoh, Khay Guan, Toh, Han Chong, Yong, Wei Peng, Cheong, Hyun Cheol, Rha, Sun Young, Boussioutas, Alex, Grabsch, Heike, Rozen, Steve, Tan, Patrick

“…Gastric cancer is a major gastrointestinal malignancy for which targeted therapies are emerging as treatment options. This study sought to identify the most…”
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Adoptive T-cell Transfer and Chemotherapy in the First-line Treatment of Metastatic and/or Locally Recurrent Nasopharyngeal Carcinoma by Chia, Whay-Kuang, Teo, Marissa, Wang, Who-Whong, Lee, Bernett, Ang, Soo-Fan, Tai, Wai-Meng, Chee, Chit-Lai, Ng, Joanna, Kan, Rebecca, Lim, Wan-Teck, Tan, Sze-Huey, Ong, Whee-Sze, Cheung, Yin-Bun, Tan, Eng-Huat, Connolly, John E, Gottschalk, Stephen, Toh, Han-Chong

“…The outcomes for patients with metastatic or locally recurrent Epstein–Barr virus (EBV)-positive nasopharyngeal carcinoma (NPC) remain poor. Adoptive…”
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Zinc Finger Nuclease‐Expressing Baculoviral Vectors Mediate Targeted Genome Integration of Reprogramming Factor Genes to Facilitate the Generation of Human Induced Pluripotent Stem Cells by Phang, Rui-Zhe, Tay, Felix Chang, Goh, Sal-Lee, Lau, Cia-Hin, Zhu, Haibao, Tan, Wee-Kiat, Liang, Qingle, Chen, Can, Du, Shouhui, Li, Zhendong, Tay, Johan Chin-Kang, Wu, Chunxiao, Zeng, Jieming, Fan, Weimin, Toh, Han Chong, Wang, Shu

“…This study reports the successful reprogramming of human fibroblasts into a state of pluripotency by baculoviral transduction‐mediated, site‐specific…”
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Analysis and Validation of Human Targets and Treatments Using a Hepatocellular Carcinoma–Immune Humanized Mouse Model by Zhao, Yue, Wang, Jiaxu, Liu, Wai Nam, Fong, Shin Yie, Shuen, Timothy Wai Ho, Liu, Min, Harden, Sarah, Tan, Sue Yee, Cheng, Jia Ying, Tan, Wilson Wei Sheng, Chan, Jerry Kok Yen, Chee, Cheng Ean, Lee, Guan Huei, Toh, Han Chong, Lim, Seng Gee, Wan, Yue, Chen, Qingfeng

“…Background and Aims Recent development of multiple treatments for human hepatocellular carcinoma (HCC) has allowed for the selection of combination therapy to…”
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Immune Microenvironment in Tumor Progression: Characteristics and Challenges for Therapy by Chew, Valerie, Toh, Han Chong, Abastado, Jean-Pierre

“…The tumor microenvironment plays a critical role in cancer development, progression, and control. The molecular and cellular nature of the tumor immune…”
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Hepatocellular Carcinoma: Current Drug Therapeutic Status, Advances and Challenges by Zheng, Shunzhen, Chan, Siew Wee, Liu, Fei, Liu, Jun, Chow, Pierce Kah Hoe, Toh, Han Chong, Hong, Wanjin

“…Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for ~90% of liver neoplasms. It is the second leading cause of…”
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