Search Results - "Chomienne, Odile"

Heteromultimeric Kv1.2-Kv1.5 Channels Underlie 4-Aminopyridine-Sensitive Delayed Rectifier K+ Current of Rabbit Vascular Myocytes by Kerr, Paul M, Clément-Chomienne, Odile, Thorneloe, Kevin S, Chen, Tim T, Ishii, Kuniaki, Sontag, David P, Walsh, Michael P, Cole, William C

“…The molecular identity of vascular delayed rectifier K channels (KDR) is poorly characterized. Inhibition by 4-aminopyridine (4-AP) of KDR of rabbit portal…”
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The Crystal Structure of Carnitine Palmitoyltransferase 2 and Implications for Diabetes Treatment by Rufer, Arne C., Thoma, Ralf, Benz, Jörg, Stihle, Martine, Gsell, Bernard, De Roo, Elodie, Banner, David W., Mueller, Francis, Chomienne, Odile, Hennig, Michael

“…Carnitine palmitoyltransferases 1 and 2 (CPTs) facilitate the import of long-chain fatty acids into mitochondria. Modulation of the catalytic activity of the…”
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ATP-Sensitive K+ Channels of Vascular Smooth Muscle Cells by COLE, WILLIAM C., CLÉMENT-CHOMIENNE, ODILE

“…ATP‐sensitive potassium channels (KATP) of vascular smooth muscle cells represent potential therapeutic targets for control of abnormal vascular contractility…”
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Virtual Screening for Bioactive Molecules by Evolutionary De Novo Design by Schneider, Gisbert, Clément-Chomienne, Odile, Hilfiger, Laurence, Schneider, Petra, Kirsch, Stefan, Böhm, Hans-Joachim, Neidhart, Werner

“…Potent K+‐channel blocking agents were generated de novo using a novel computer‐based evolutionary design strategy (TOPAS). The method is based on an adaptive…”
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Myogenic regulation of arterial diameter: role of potassium channels with a focus on delayed rectifier potassium current by Cole, William C, Chen, Tim T, Clément-Chomienne, Odile

“…The phenomenon of myogenic constriction of arterial resistance vessels in response to increased intraluminal pressure has been known for over 100 years, yet…”
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Identification, cloning and expression of rabbit vascular smooth muscle Kv1.5 and comparison with native delayed rectifier K+ current by Clément‐Chomienne, Odile, Ishii, Kuniaki, Walsh, Michael P., Cole, William C.

“…The molecular basis of voltage-gated, delayed rectifier K + (K DR ) channels in vascular smooth muscle cells is poorly defined. In this study we employed (i)…”
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Carnitine Palmitoyltransferase (CPT) Modulators: A Medicinal Chemistry Perspective on 35 Years of Research by Ceccarelli, Simona M, Chomienne, Odile, Gubler, Marcel, Arduini, Arduino

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Effects of anorexinogen agents on cloned voltage-gated K(+) channel hKv1.5 by Perchenet, L, Hilfiger, L, Mizrahi, J, Clément-Chomienne, O

“…Appetite suppressants have been associated with primary pulmonary hypertension (PPH), inhibition of voltage-gated potassium channels, membrane depolarization,…”
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Smooth muscle protein kinase C by Walsh, M P, Andrea, J E, Allen, B G, Clément-Chomienne, O, Collins, E M, Morgan, K G

“…Protein kinase C (PKC) was first implicated in the regulation of smooth muscle contraction with the observation that phorbol esters induce slowly developing,…”
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Phenylephrine and ATP enhance an amiloride insensitive bicarbonate-dependent alkalinizing mechanism in rat single cardiomyocytes by TERZIC, A, PUCEAT, M, CLEMENT-CHOMIENNE, O, VASSORT, G

“…To expel the excess protons generated during a cellular acidification and to fully recover basal intracellular pH (pHi), cardiac cells rely on the…”
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Carnitine palmitoyltransferase 2: Analysis of membrane association and complex structure with a substrate analog by Rufer, Arne C., Lomize, Andrei, Benz, Jörg, Chomienne, Odile, Thoma, Ralf, Hennig, Michael

“…The mitochondrial membrane-associated carnitine palmitoyltransferase system is a validated target for the treatment of type 2 diabetes mellitus. To further…”
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Properties, regulation, and role of potassium channels of smooth muscle by Cole, William C, Clément-Chomienne, Odile

“…This chapter reviews the properties and regulation of the four distinct classes of K+ channels of smooth muscle, including (1) KIR, inwardly rectifying K+…”
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Angiotensin II activation of protein kinase C decreases delayed rectifier K+ current in rabbit vascular myocytes by Clément-Chomienne, O, Walsh, M P, Cole, W C

“…1. The effect of angiotension II (Ang) on delayed rectifier K+ current (IK(V)) was studied in isolated rabbit portal vein smooth muscle cells using standard…”
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Protein kinase C mediation of Ca(2+)-independent contractions of vascular smooth muscle by Walsh, M P, Horowitz, A, Clément-Chomienne, O, Andrea, J E, Allen, B G, Morgan, K G

“…Tumour-promoting phorbol esters induce slow, sustained contractions of vascular smooth muscle, suggesting that protein kinase C (PKC) may play a role in the…”
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Epsilon-isoenzyme of protein kinase C induces a Ca(2+)-independent contraction in vascular smooth muscle by Horowitz, A, Clément-Chomienne, O, Walsh, M P, Morgan, K G

“…We provide here the first direct evidence for in situ functional specificity of protein kinase C (PKC)-epsilon as a regulator of smooth muscle contractility…”
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Protein kinase C inhibits delayed rectifier K+ current in rabbit vascular smooth muscle cells by Aiello, E A, Clément-Chomienne, O, Sontag, D P, Walsh, M P, Cole, W C

“…The effect of protein kinase C (PKC) activation on 4-aminopyridine (4-AP)-sensitive delayed rectifier current (IdK) was studied in isolated rabbit portal vein…”
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Identification of protein kinase C isoenzymes in smooth muscle: partial purification and characterization of chicken gizzard PKC zeta by Clément-Chomienne, O, Walsh, M P

“…The pattern of expression of protein kinase C (PKC) isoenzymes was examined in chicken gizzard smooth muscle using isoenzyme-specific antibodies: alpha, delta,…”
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Evolutionäres De‐novo‐Design bioaktiver Moleküle: ein Ansatz zum virtuellen Screening by Schneider, Gisbert, Clément‐Chomienne, Odile, Hilfiger, Laurence, Schneider, Petra, Kirsch, Stefan, Böhm, Hans‐Joachim, Neidhart, Werner

“…Wirksame Kaliumkanalblocker wurden mit TOPAS entwickelt, einem neuartigen, rechnergestützten Verfahren für das Moleküldesign auf Templatbasis. Die Methode…”
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Evolutionäres De-novo-Design bioaktiver Moleküle: ein Ansatz zum virtuellen Screening by Schneider, Gisbert, Clément-Chomienne, Odile, Hilfiger, Laurence, Schneider, Petra, Kirsch, Stefan, Böhm, Hans-Joachim, Neidhart, Werner

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Characterization of mibefradil block of the human heart delayed rectifier hKv1.5 by Perchenet, L, Clément-Chomienne, O

“…The goal of this study was to analyze the effects of mibefradil on a human cardiac K(+) channel (hKv1.5) stably expressed in Chinese hamster ovary cells using…”
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