Search Results - "Chomez, Patrick"

An inducible mouse model of melanoma expressing a defined tumor antigen by HUIJBERS, Ivo J, KRIMPENFORT, Paul, CHOMEZ, Patrick, VAN DER VALK, Martin A, SONG, Ji-Ying, INDERBERG-SUSO, Else-Marit, SCHMITT-VERHULST, Anne-Marie, BERNS, Anton, VAN DEN EYNDE, Benoit J

“…Cancer immunotherapy based on vaccination with defined tumor antigens has not yet shown strong clinical efficacy, despite promising results in preclinical…”
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Comparative expression analysis of the MAGED genes during embryogenesis and brain development by Bertrand, Mathieu, Huijbers, Ivo, Chomez, Patrick, De Backer, Olivier

“…The MAGED gene subfamily contains three genes in mouse and four in human. The MAGED1, D2, and D3 proteins are highly conserved between mouse and human, whereas…”
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MAGE‐A4, a germ cell specific marker, is expressed differentially in testicular tumors by Aubry, Florence, Satie, Anne‐Pascale, Rioux‐Leclercq, Nathalie, Rajpert‐De Meyts, Ewa, Spagnoli, Giulio C., Chomez, Patrick, De Backer, Olivier, Jégou, Bernard, Samson, Michel

“…BACKGROUND Testicular germ cell tumors are the most common malignancy in young males, and the frequency of these tumors has risen dramatically over the last…”
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Structure, chromosomal localization, and expression of 12 genes of the MAGE family by De Plaen, E, Arden, K, Traversari, C, Gaforio, J J, Szikora, J P, De Smet, C, Brasseur, F, van der Bruggen, P, Lethé, B, Lurquin, C

“…We reported previously that human gene MAGE-1 directs the expression of a tumor antigen recognized on a melanoma by autologous cytolytic T lymphocytes. Probing…”
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GlaxoSmithKline Adjuvant Systems in vaccines: concepts, achievements and perspectives by Garçon, Nathalie, Chomez, Patrick, Van Mechelen, Marcelle

“…The need for potentiating immune responses to recombinant or subunit antigens has prompted GlaxoSmithKline (GSK) Biologicals to develop various Adjuvant…”
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Adjuvant System AS03 containing α-tocopherol modulates innate immune response and leads to improved adaptive immunity by Morel, Sandra, Didierlaurent, Arnaud, Bourguignon, Patricia, Delhaye, Sophie, Baras, Benoît, Jacob, Valérie, Planty, Camille, Elouahabi, Abdelatif, Harvengt, Pol, Carlsen, Harald, Kielland, Anders, Chomez, Patrick, Garçon, Nathalie, Van Mechelen, Marcelle

“…Abstract AS03 is an Adjuvant System (AS) containing α-tocopherol and squalene in an oil-in-water (o/w) emulsion. AS03 has been considered for the development…”
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An overview of the MAGE gene family with the identification of all human members of the family by CHOMEZ, Patrick, DE BACKER, Olivier, BERTRAND, Mathieu, DE PLAEN, Etienne, BOON, Thierry, LUCAS, Sophie

“…The first human members of the MAGE gene family that have been described are expressed in tumor cells but silent in normal adult tissues except in the male…”
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A New Family of Mouse Genes Homologous to the HumanMAGEGenes by De Plaen, Etienne, De Backer, Olivier, Arnaud, Danielle, Bonjean, Bernard, Chomez, Patrick, Martelange, Valérie, Avner, Philip, Baldacci, Patricia, Babinet, Charles, Hwang, Sue-Yun, Knowles, Barbara, Boon, Thierry

“…The humanMAGEgenes are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells…”
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Minimal tolerance to a tumor antigen encoded by a cancer-germline gene by Huijbers, Ivo J, Soudja, Saïdi M, Uyttenhove, Catherine, Buferne, Michel, Inderberg-Suso, Else-Marit, Colau, Didier, Pilotte, Luc, Powis de Tenbossche, Céline G, Chomez, Patrick, Brasseur, Francis, Schmitt-Verhulst, Anne-Marie, Van den Eynde, Benoît J

“…Central tolerance toward tissue-restricted Ags is considered to rely on ectopic expression in the thymus, which was also observed for tumor Ags encoded by…”
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A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma by van der Bruggen, Pierre, Traversari, Catia, Chomez, Patrick, Lurquin, Christophe, De Plaen, Etienne, Van den Eynde, Benoît J, Knuth, Alexander, Boon, Thierry

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Adjuvant System AS03 containing [alpha]-tocopherol modulates innate immune response and leads to improved adaptive immunity by Morel, Sandra, Didierlaurent, Arnaud, Bourguignon, Patricia, Delhaye, Sophie, Baras, Benoît, Jacob, Valérie, Planty, Camille, Elouahabi, Abdelatif, Harvengt, Pol, Carlsen, Harald, Kielland, Anders, Chomez, Patrick, Garçon, Nathalie, van Mechelen, Marcelle

“…AS03 is an Adjuvant System (AS) containing α-tocopherol and squalene in an oil-in-water (o/w) emulsion. AS03 has been considered for the development of…”
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Characterization of the GAGE genes that are expressed in various human cancers and in normal testis by DE BACKER, O, ARDEN, K. C, VAN DEN EYNDE, B, BOON, T, VAN DER BRUGGEN, P, BORETTI, M, VANTOMME, V, DE SMET, C, CZEKAY, S, VIARS, C. S, DE PLAEN, E, BRASSEUR, F, CHOMEZ, P

“…The GAGE-1 gene was identified previously as a gene that codes for an antigenic peptide, YRPRPRRY, which was presented on a human melanoma by HLA-Cw6 molecules…”
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A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E by TRAVERSARI, C, VAN DER BRUGGEN, P, LUESCHER, I. F, LURQUIN, C, CHOMEZ, P, VAN PEL, A, DE PLAEN, E, AMAR-COSTESEC, A, BOON, T

“…We have reported the identification of human gene MAGE-1, which directs the expression of an antigen recognized on a melanoma by autologous cytolytic T…”
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Increased cell death and delayed development in the cerebellum of mice lacking the rev-erbAα orphan receptor by Chomez, Patrick, Neveu, Isabelle, Mansén, Anethe, Kiesler, Eva, Larsson, Lars, Vennström, Björn, Arenas, Ernest

“…ABSTRACT The rev-erbAα gene, belonging to the steroid receptor superfamily of transcription factors, is highly conserved during evolution but little is known…”
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Differential and opposed transcriptional effects of protein fusions containing the VP16 activation domain by Matis, Christelle, Chomez, Patrick, Picard, Jacques, Rezsohazy, René

“…Overexpression of strong transcriptional activators like herpes simplex virion protein 16 (VP16) may lead to non-specific inhibition of gene expression as a…”
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Thymocyte-Intrinsic Genetic Factors Influence CD8 T Cell Lineage Commitment and Affect Selection of a Tumor-Reactive TCR by Shanker, Anil, Auphan-Anezin, Nathalie, Chomez, Patrick, Giraudo, Laurent, Eynde, Benoit Van den, Schmitt-Verhulst, Anne-Marie

“…Selection of immature CD4CD8 double-positive (DP) thymocytes for CD4 or CD8-lineage commitment is controlled by the interaction of the TCR with stromal…”
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A new family of mouse genes homologous to the human MAGE genes by DE PLAEN, E, DE BACKER, O, KNOWLES, B, BOON, T, ARNAUD, D, BONJEAN, B, CHOMEZ, P, MARTELANGE, V, AVNER, P, BALDACCI, P, BABINET, C, HWANG, S.-Y

“…The human MAGE genes are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly,…”
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Structure of the gene of tum- transplantation antigen P198: a point mutation generates a new antigenic peptide by Sibille, C, Chomez, P, Wildmann, C, Van Pel, A, De Plaen, E, Maryanski, J L, de Bergeyck, V, Boon, T

“…Mutagen treatment of mouse tumor cell line P815 produces tum- variants that are rejected by syngeneic mice because they express new transplantation antigens…”
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Immunogenic (tum-) Variants of Mouse Tumor P815: Cloning of the Gene of tum- Antigen P91A and Identification of the tum- Mutation by De Plaen, Etienne, Lurquin, Christophe, Van Pel, Aline, Mariamé, Bernard, Szikora, Jean-Pierre, Wölfel, Thomas, Sibille, Catherine, Chomez, Patrick, Boon, Thierry

“…Mutagen treatment of mouse P815 tumor cells produces tum- variants that are rejected by syngeneic mice because these variants express new surface antigens…”
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Positive and negative thymic selection in T cell receptor-transgenic mice correlate with Nur77 mRNA expression by Xue, Y, Chomez, P, Castanos-Velez, E, Biberfeld, P, Perlmann, T, Jondal, M

“…The orphan nuclear receptor Nur77 has been implicated in thymic negative selection. We studied the effect of two T cell receptor (TCR) transgenes on positive…”
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