Search Results - "Chojnowska, Kathrin"
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Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle
Published in Nature communications (19-04-2022)“…Preserving skeletal muscle function is essential to maintain life quality at high age. Calorie restriction (CR) potently extends health and lifespan, but is…”
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Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I
Published in The Journal of clinical investigation (01-02-2017)“…Myotonic dystrophy type I (DM1) is a disabling multisystemic disease that predominantly affects skeletal muscle. It is caused by expanded CTG repeats in the…”
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Author Correction: Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle
Published in Nature communications (27-04-2022)Get full text
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mTORC1 signalling is not essential for the maintenance of muscle mass and function in adult sedentary mice
Published in Journal of cachexia, sarcopenia and muscle (01-02-2020)“…Background The balance between protein synthesis and degradation (proteostasis) is a determining factor for muscle size and function. Signalling via the…”
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Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis
Published in Communications biology (27-10-2022)“…Muscle size is controlled by the PI3K-PKB/Akt-mTORC1-FoxO pathway, which integrates signals from growth factors, energy and amino acids to activate protein…”
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