Search Results - "Chojnowska, Kathrin"

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    Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I by Brockhoff, Marielle, Rion, Nathalie, Chojnowska, Kathrin, Wiktorowicz, Tatiana, Eickhorst, Christopher, Erne, Beat, Frank, Stephan, Angelini, Corrado, Furling, Denis, Rüegg, Markus A, Sinnreich, Michael, Castets, Perrine

    Published in The Journal of clinical investigation (01-02-2017)
    “…Myotonic dystrophy type I (DM1) is a disabling multisystemic disease that predominantly affects skeletal muscle. It is caused by expanded CTG repeats in the…”
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    Journal Article
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    mTORC1 signalling is not essential for the maintenance of muscle mass and function in adult sedentary mice by Ham, Alexander S., Chojnowska, Kathrin, Tintignac, Lionel A., Lin, Shuo, Schmidt, Alexander, Ham, Daniel J., Sinnreich, Michael, Rüegg, Markus A.

    Published in Journal of cachexia, sarcopenia and muscle (01-02-2020)
    “…Background The balance between protein synthesis and degradation (proteostasis) is a determining factor for muscle size and function. Signalling via the…”
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    Journal Article
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    Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis by Kaiser, Marco S., Milan, Giulia, Ham, Daniel J., Lin, Shuo, Oliveri, Filippo, Chojnowska, Kathrin, Tintignac, Lionel A., Mittal, Nitish, Zimmerli, Christian E., Glass, David J., Zavolan, Mihaela, Rüegg, Markus A.

    Published in Communications biology (27-10-2022)
    “…Muscle size is controlled by the PI3K-PKB/Akt-mTORC1-FoxO pathway, which integrates signals from growth factors, energy and amino acids to activate protein…”
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    Journal Article