Search Results - "Chojkier, Mario"

Ledipasvir and Sofosbuvir for 8 or 12 Weeks for Chronic HCV without Cirrhosis by Kowdley, Kris V, Gordon, Stuart C, Reddy, K. Rajender, Rossaro, Lorenzo, Bernstein, David E, Lawitz, Eric, Shiffman, Mitchell L, Schiff, Eugene, Ghalib, Reem, Ryan, Michael, Rustgi, Vinod, Chojkier, Mario, Herring, Robert, Di Bisceglie, Adrian M, Pockros, Paul J, Subramanian, G. Mani, An, Di, Svarovskaia, Evguenia, Hyland, Robert H, Pang, Phillip S, Symonds, William T, McHutchison, John G, Muir, Andrew J, Pound, David, Fried, Michael W

“…In previously untreated patients with HCV genotype 1 infection without cirrhosis, the rate of sustained virologic response was 94% with 8 weeks of…”
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Blood Microbiome Quantity and the Hyperdynamic Circulation in Decompensated Cirrhotic Patients by Traykova, Daniela, Schneider, Beacher, Chojkier, Mario, Buck, Martina

“…Recently, a complex microbiome was comprehensibly characterized in the serum and ascitic fluid of cirrhotic patients. In the current study, we investigated for…”
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Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids by Chojkier, Mario

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Novel inflammatory biomarkers of portal pressure in compensated cirrhosis patients by Buck, Martina, Garcia‐Tsao, Guadalupe, Groszmann, Roberto J., Stalling, Caitlin, Grace, Norman D., Burroughs, Andrew K., Patch, David, Matloff, Daniel S., Clopton, Paul, Chojkier, Mario

“…The rationale for screening inflammatory serum biomarkers of the hepatic vein pressure gradient (HVPG) is based on the fact that portal hypertension is…”
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A ribosomal S-6 kinase-mediated signal to C/EBP-beta is critical for the development of liver fibrosis by Buck, Martina, Chojkier, Mario

“…In response to liver injury, hepatic stellate cell (HSC) activation causes excessive liver fibrosis. Here we show that activation of RSK and phosphorylation of…”
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C/EBPβ-Thr217 phosphorylation signaling contributes to the development of lung injury and fibrosis in mice by Buck, Martina, Chojkier, Mario

“…Although C/EBPβ(ko) mice are refractory to Bleomycin-induced lung fibrosis the molecular mechanisms remain unknown. Here we show that blocking the ribosomal…”
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Pioglitazone decreases hepatitis C viral load in overweight, treatment naïve, genotype 4 infected-patients: a pilot study by Chojkier, Mario, Elkhayat, Hisham, Sabry, Dina, Donohue, Michael, Buck, Martina

“…Insulin resistance (IR) is induced by chronic hepatitis C virus (HCV) genotypes 1 and 4 infections. It is not known whether drugs that affect IR such as…”
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Gastric adenocarcinoma inducing portal hypertension： A rare presentation by Ghosh, Pradipta, Miyai, Katsumi, Chojkier, Mario

“…Advanced gastric cancer usually presents with symptoms due to direct extension into adjacent viscera, distant metastases from lymphatic or hematogenic…”
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Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain by Trautwein, Christian, Caelles, Carme, van der Geer, Peter, Hunter, Tony, Karin, Michael, Chojkier, Mario

“…One of the members of the bZIP family of transcriptional activators is NF-IL6/LAP (IL-6 DBP, C/EBP beta, CRP2). NF-IL6/LAP protein is highly expressed in liver…”
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Inhibition of Albumin Synthesis in Chronic Diseases: Molecular Mechanisms by Chojkier, Mario

“…The albumin gene is expressed specifically in the liver after birth, and this expression is regulated predominantly at the transcriptional level. Regulatory…”
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Troglitazone and liver injury: In search of answers by CHOJKIER, Mario

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No Significant Effects of Ethyl-Eicosapentanoic Acid on Histologic Features of Nonalcoholic Steatohepatitis in a Phase 2 Trial by Sanyal, Arun J, Abdelmalek, Manal F, Suzuki, Ayako, Cummings, Oscar W, Chojkier, Mario

“…Background & Aims n-3 polyunsaturated fatty acids reduce insulin resistance, lipogenesis, and inflammation, which are features of nonalcoholic steatohepatitis…”
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C/EBPβ-Thr217 Phosphorylation Stimulates Macrophage Inflammasome Activation and Liver Injury by Buck, Martina, Solis-Herruzo, Jose, Chojkier, Mario

“…Amplification of liver injury is mediated by macrophages but the signaling by which the macrophage inflammasome enhances liver injury is not completely…”
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A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis by Ratziu, Vlad, Sheikh, Muhammad Y., Sanyal, Arun J., Lim, Joseph K., Conjeevaram, Hari, Chalasani, Naga, Abdelmalek, Manal, Bakken, Anezi, Renou, Christophe, Palmer, Melissa, Levine, Robert A., Bhandari, B. Raj, Cornpropst, Melanie, Liang, Wei, King, Benjamin, Mondou, Elsa, Rousseau, Franck S., McHutchison, John, Chojkier, Mario

“…In nonalcoholic steatohepatitis (NASH), the extent of hepatocyte apoptosis correlates with disease severity. Reducing hepatocyte apoptosis with the selective…”
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C/EBPβ Associates With Caspase 8 Complex Proteins and Modulates Apoptosis in Hepatic Stellate Cells by Buck, Martina, Chojkier, Mario

“…GOALSTo analyze the role of C/EBPβ phosphorylation on hepatic stellate cell survival/cell death. BACKGROUNDActivation and survival of stellate cells is…”
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Ledipasvir and Sofosbuvir for Untreated HCV Genotype 1 Infection by Afdhal, Nezam, Zeuzem, Stefan, Kwo, Paul, Chojkier, Mario, Gitlin, Norman, Puoti, Massimo, Romero-Gomez, Manuel, Zarski, Jean-Pierre, Agarwal, Kosh, Buggisch, Peter, Foster, Graham R, Bräu, Norbert, Buti, Maria, Jacobson, Ira M, Subramanian, G. Mani, Ding, Xiao, Mo, Hongmei, Yang, Jenny C, Pang, Phillip S, Symonds, William T, McHutchison, John G, Muir, Andrew J, Mangia, Alessandra, Marcellin, Patrick

“…In this trial, previously untreated patients with hepatitis C virus genotype 1 infection were randomly assigned to 12 or 24 weeks of ledipasvir and sofosbuvir,…”
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Therapeutic strategies for hepatic fibrosis by Chojkier, M, Brenner, D A

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C/EBPbeta phosphorylation rescues macrophage dysfunction and apoptosis induced by anthrax lethal toxin by Buck, Martina, Chojkier, Mario

“…Bacillus anthracis lethal toxin (LT) impairs innate and adaptive immunity. Anthrax lethal factor stimulates cleavage of MAPK kinases, which prevents the…”
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C/EBP[beta]-Thr217 Phosphorylation Stimulates Macrophage Inflammasome Activation and Liver Injury by Buck, Martina, Solis-herruzo, Jose, Chojkier, Mario

“…Amplification of liver injury is mediated by macrophages but the signaling by which the macrophage inflammasome enhances liver injury is not completely…”
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C/EBPbeta associates with caspase 8 complex proteins and modulates apoptosis in hepatic stellate cells by Buck, Martina, Chojkier, Mario

“…To analyze the role of C/EBPbeta phosphorylation on hepatic stellate cell survival/cell death. Activation and survival of stellate cells is critical for the…”
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