Evaluation of dental maturity in Muenke syndrome, Saethre-Chotzen syndrome, and TCF12-related craniosynostosis

To determine whether dental maturity (dental development) was delayed in patients with Muenke syndrome, Saethre-Chotzen syndrome, and TCF12-related craniosynostosis, compared with a Dutch control group without syndromes. This study included 60 patients (38 patients with Muenke syndrome, 17 patients...

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Bibliographic Details
Published in:	European journal of orthodontics Vol. 44; no. 3; pp. 287 - 293
Main Authors:	Choi, Tsun M, Kramer, Gem J C, Goos, Jacqueline A C, Mathijssen, Irene M J, Wolvius, Eppo B, Ongkosuwito, Edwin M
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 24-05-2022
Subjects:	Acrocephalosyndactylia - diagnostic imaging Acrocephalosyndactylia - surgery Basic Helix-Loop-Helix Transcription Factors Child Child, Preschool Craniosynostoses - complications Craniosynostoses - diagnostic imaging Craniosynostoses - surgery Humans Netherlands Original Syndrome Netherlands
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Summary:	To determine whether dental maturity (dental development) was delayed in patients with Muenke syndrome, Saethre-Chotzen syndrome, and TCF12-related craniosynostosis, compared with a Dutch control group without syndromes. This study included 60 patients (38 patients with Muenke syndrome, 17 patients with Saethre-Chotzen syndrome, and 5 with TCF12-related craniosynostosis), aged 5.8-16.8 years that were treated at the Department of Oral Maxillofacial Surgery, Special Dental Care, and Orthodontics, in Sophia Children's Hospital, Erasmus University Medical Center, Rotterdam, the Netherlands. Dental age was calculated according to Demirjian's index of dental maturity. The control group included 451 children without a syndrome. Compared with the control group, dental development was delayed by an average of one year in 5- to 8-year-old patients with Muenke syndrome (P = 0.007) and in 8- to 10-year-old patients with Saethre-Chotzen syndrome (P = 0.044), but not in patients with TCF12-related craniosynostosis. Our results indicated that dental development was delayed by one year, on average, in patients with Muenke syndrome and Saethre-Chotzen syndrome, compared with a Dutch control group without syndromes. Our findings have improved the understanding of dental development in patients with Muenke and Saethre-Chotzen syndrome. These results can provide guidance on whether the orthodontist needs to consider growth disturbances related to dental development.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0141-5387 1460-2210
DOI:	10.1093/ejo/cjab056