Search Results - "Choi, Sung E"

Transcriptional regulation of autophagy by an FXR–CREB axis by Seok, Sunmi, Fu, Ting, Choi, Sung-E, Li, Yang, Zhu, Rong, Kumar, Subodh, Sun, Xiaoxiao, Yoon, Gyesoon, Kang, Yup, Zhong, Wenxuan, Ma, Jian, Kemper, Byron, Kemper, Jongsook Kim

“…The FXR–CREB axis is identified as a key physiological switch that regulates autophagy during feeding/fasting cycles; in the fed state, the nuclear receptor…”
Get full text

Elevated microRNA‐34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT by Choi, Sung‐E, Fu, Ting, Seok, Sunmi, Kim, Dong‐Hyun, Yu, Eunkyung, Lee, Kwan‐Woo, Kang, Yup, Li, Xiaoling, Kemper, Byron, Kemper, Jongsook K.

“…Summary SIRT1 is an NAD+‐dependent deacetylase that is implicated in prevention of many age‐related diseases including metabolic disorders. As SIRT1…”
Get full text

Amphiregulin Induces iNOS and COX-2 Expression through NF-κB and MAPK Signaling in Hepatic Inflammation by Heo, Yu Jung, Lee, Nami, Choi, Sung-E., Jeon, Ja Young, Han, Seung Jin, Kim, Dae Jung, Kang, Yup, Lee, Kwan Woo, Kim, Hae Jin

“…Background. Inflammation is a major cause of hepatic tissue damage and accelerates the progression of nonalcoholic fatty liver disease (NAFLD). Amphiregulin…”
Get full text

Anti-inflammatory Effects of Empagliflozin and Gemigliptin on LPS-Stimulated Macrophage via the IKK/NF-κB, MKK7/JNK, and JAK2/STAT1 Signalling Pathways by Lee, Nami, Heo, Yu Jung, Choi, Sung-E, Jeon, Ja Young, Han, Seung Jin, Kim, Dae Jung, Kang, Yup, Lee, Kwan Woo, Kim, Hae Jin

“…Background. Sodium-glucose cotransporter 2 (SGLT2) and dipeptidyl peptidase-4 (DPP-4) inhibitors are glucose-lowering drugs whose anti-inflammatory properties…”
Get full text

Visfatin exacerbates hepatic inflammation and fibrosis in a methionine‐choline‐deficient diet mouse model by Heo, Yu Jung, Choi, Sung‐E, Lee, Nami, Jeon, Ja Young, Han, Seung Jin, Kim, Dae Jung, Kang, Yup, Lee, Kwan Woo, Kim, Hae Jin

“…Background and Aim Non‐alcoholic fatty liver disease (NAFLD) ranges from simple steatosis to non‐alcoholic steatohepatitis, which is characterized by hepatic…”
Get full text

Visfatin Induces Inflammation and Insulin Resistance via the NF-κB and STAT3 Signaling Pathways in Hepatocytes by Kim, Hae Jin, Kang, Yup, Kim, Dae Jung, Han, Seung Jin, Jeon, Ja Young, Choi, Sung-E, Heo, Yu Jung, Lee, Kwan-Woo

“…Background. It has been suggested that visfatin, which is an adipocytokine, exhibits proinflammatory properties and is associated with insulin resistance…”
Get full text

Mitochondrial protease ClpP supplementation ameliorates diet-induced NASH in mice by Choi, Sung-E, Hwang, Yoonjung, Lee, Soo-Jin, Jung, Hyunkyung, Shin, Tae Hwan, Son, Youngho, Park, Seokho, Han, Seung Jin, Kim, Hae Jin, Lee, Kwan Woo, Lee, Gwang, Kemper, Jongsook Kim, Song, Hyun Kyu, Kang, Yup

“…Mitochondrial dysfunction is considered a pathogenic linker in the development of non-alcoholic steatohepatitis (NASH). Inappropriate mitochondrial…”
Get full text

Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor β-Klotho by Fu, Ting, Choi, Sung-E, Kim, Dong-Hyun, Seok, Sunmi, Suino-Powell, Kelly M, Xu, H. Eric, Kemper, Jongsook Kim

“…MicroRNA-34a (miR-34a) is the most highly elevated hepatic miR in obese mice and is also substantially elevated in patients who have steatosis, but its role in…”
Get full text

HDAC11 Regulates Palmitate-induced NLRP3 Inflammasome Activation by Inducing YAP Expression in THP-1 Cells and PBMCs by Byeon, Hye-Eun, Choi, Sung-E, Kim, Yujin, Choi, Suji, Lee, Soo-Jin, Kim, Dong Hyun, Mo, Jung-Soon, Jeon, Ja Young

“…Abstract Histone deacetylase 11 (HDAC11) has been implicated in the pathogenesis of metabolic diseases characterized by chronic low-grade inflammation, such as…”
Get full text

Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver by Choi, Sung E., Kwon, Sanghoon, Seok, Sunmi, Xiao, Zhen, Lee, Kwan-Woo, Kang, Yup, Li, Xiaoling, Shinoda, Kosaku, Kajimura, Shingo, Kemper, Byron, Kemper, Jongsook Kim

“…Sirtuin1 (SIRT1) deacetylase delays and improves many obesity-related diseases, including nonalcoholic fatty liver disease (NAFLD) and diabetes, and has…”
Get full text

GLP‑1 improves palmitate‑induced insulin resistance in human skeletal muscle via SIRT1 activity by Jeon, Ja Young, Choi, Sung-E, Ha, Eun Suk, Lee, Han Byeol, Kim, Tae Ho, Han, Seung Jin, Kim, Hae Jin, Kim, Dae Jung, Kang, Yup, Lee, Kwan-Woo

“…The present study investigated whether glucagon like peptide‑1 (GLP‑1) improves glucose uptake through glucose transporter type 4 (GLUT4), mediated by the…”
Get full text

CD38 Inhibition Protects Fructose-Induced Toxicity in Primary Hepatocytes by Lee, Soo-Jin, Choi, Sung-E, Park, Seokho, Hwang, Yoonjung, Son, Youngho, Kang, Yup

“…A fructose-enriched diet is thought to contribute to hepatic injury in developing non-alcoholic steatohepatitis (NASH). However, the cellular mechanism of…”
Get full text

Protective effect of empagliflozin against palmitate-induced lipotoxicity through AMPK in H9c2 cells by Song, Min-Woo, Cui, Wenhao, Lee, Chang-Gun, Cui, Rihua, Son, Young Ho, Kim, Young Ha, Kim, Yujin, Kim, Hae Jin, Choi, Sung-E, Kang, Yup, Kim, Tae Ho, Jeon, Ja Young, Lee, Kwan-Woo

“…Sodium-glucose cotransporter 2 (SGLT2) inhibitors have recently emerged as novel cardioprotective agents. However, their direct impact on cardiomyocyte injury…”
Get full text

Sodium fluorocitrate having protective effect on palmitate-induced beta cell death improves hyperglycemia in diabetic db/db mice by Jung, Ik-Rak, Choi, Sung-E., Hong, Seung A., Hwang, Yoonjung, Kang, Yup

“…Beta cell loss and insulin resistance play roles in the pathogenesis of type 2 diabetes. Elevated levels of free fatty acids in plasma might contribute to the…”
Get full text

Sodium fluorocitrate having inhibitory effect on fatty acid uptake ameliorates high fat diet-induced non-alcoholic fatty liver disease in C57BL/6J mice by Hong, Seung A., Jung, Ik-Rak, Choi, Sung-E., Hwang, Yoonjung, Lee, Soo-Jin, Son, Youngho, Heo, Yu Jung, Cui, Rihua, Han, Seung Jin, Kim, Hae Jin, Lee, Kwan Woo, Kang, Yup

“…Non-alcoholic fatty liver disease (NAFLD) is excessive fat build-up in the liver without alcohol consumption and includes hepatic inflammation and damage…”
Get full text

Protective Role of Autophagy in Palmitate-Induced INS-1 β-Cell Death by Choi, Sung-E, Lee, Sung-Mi, Lee, Youn-Jung, Li, Ling-Ji, Lee, Soo-Jin, Lee, Ji-Hyun, Kim, Youngsoo, Jun, Hee-Sook, Lee, Kwan-Woo, Kang, Yup

“…Autophagy, a vacuolar degradative pathway, constitutes a stress adaptation that avoids cell death or elicits the alternative cell-death pathway. This study was…”
Get full text

In Vivo Two-Photon Imaging Analysis of Dynamic Degradation of Hepatic Lipid Droplets in MS-275-Treated Mouse Liver by Lee, Chang-Gun, Lee, Soo-Jin, Park, Seokho, Choi, Sung-E, Song, Min-Woo, Lee, Hyo Won, Kim, Hae Jin, Kang, Yup, Lee, Kwan Woo, Kim, Hwan Myung, Kwak, Jong-Young, Lee, In-Jeong, Jeon, Ja Young

“…The accumulation of hepatic lipid droplets (LDs) is a hallmark of non-alcoholic fatty liver disease (NAFLD). Appropriate degradation of hepatic LDs and…”
Get full text

CCL20 induced by visfatin in macrophages via the NF-κB and MKK3/6-p38 signaling pathways contributes to hepatic stellate cell activation by Heo, Yu Jung, Choi, Sung-E, Lee, Nami, Jeon, Ja Young, Han, Seung Jin, Kim, Dae Jung, Kang, Yup, Lee, Kwan Woo, Kim, Hae Jin

“…Chemokines interact with hepatic resident cells during inflammation and fibrosis. CC chemokine ligand (CCL) 20 has been reported to be important in…”
Get full text

A Class I Histone Deacetylase Inhibitor Attenuates Insulin Resistance and Inflammation in Palmitate-Treated C2C12 Myotubes and Muscle of HF/HFr Diet Mice by Lee, Soo Jin, Choi, Sung-E, Lee, Han Byeol, Song, Min-Woo, Kim, Young Ha, Jeong, Jae Yeop, Kang, Yup, Kim, Hae Jin, Kim, Tae Ho, Jeon, Ja Young, Lee, Kwan Woo

“…Histone deacetylase (HDAC) inhibitors, which regulate gene expression by inhibiting the deacetylation of histones and nonhistone proteins, have been shown to…”
Get full text

Stimulation of Lipogenesis as Well as Fatty Acid Oxidation Protects against Palmitate-Induced INS-1 β-Cell Death by Choi, Sung-E, Jung, Ik-Rak, Lee, Youn-Jung, Lee, Soo-Jin, Lee, Ji-Hyun, Kim, Youngsoo, Jun, Hee-Sook, Lee, Kwan-Woo, Park, Chan Bae, Kang, Yup

“…Stimulation of lipid metabolism, including synthesis and oxidation, protects palmitate-induced cytotoxicity to β-cells. Saturated fatty acids are generally…”
Get full text