Search Results - "Choi, Seunga"
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Recombinant Rv1654 protein of Mycobacterium tuberculosis induces mitochondria‐mediated apoptosis in macrophage
Published in Microbiology and immunology (01-04-2021)“…Mycobacterium tuberculosis contains diverse immunologically active components. This study investigated the biological function of a newly identified component,…”
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Tumor Necrosis Factor (TNF) Receptor-associated Factor (TRAF)-interacting Protein (TRIP) Negatively Regulates the TRAF2 Ubiquitin-dependent Pathway by Suppressing the TRAF2-Sphingosine 1-Phosphate (S1P) Interaction
Published in The Journal of biological chemistry (10-04-2015)“…Background: TNF receptor-associated factor 2 (TRAF2) is a key adaptor molecule in the TNF receptor (TNFR) signaling pathway. Results: TRAF-interacting protein…”
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Clitoromegaly, Vulvovaginal Hemangioma Mimicking Pelvic Organ Prolapse, and Heavy Menstrual Bleeding: Gynecologic Manifestations of Klippel-Trénaunay Syndrome
Published in Medicina (Kaunas, Lithuania) (09-04-2021)“…Klippel-Trénaunay Syndrome (KTS) is a genetic vascular malformation involving the capillary, lymphatic, and venous channels. Prenatal sonographic diagnosis of…”
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4
TDAG51 is a crucial regulator of maternal care and depressive-like behavior after parturition
Published in PLoS genetics (28-06-2019)“…Postpartum depression is a severe emotional and mental disorder that involves maternal care defects and psychiatric illness. Postpartum depression is closely…”
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Cell wall skeleton of Mycobacterium bovis BCG enhances the vaccine potential of antigen 85B against tuberculosis by inducing Th1 and Th17 responses
Published in PloS one (08-03-2019)“…A safe and effective adjuvant is necessary to induce reliable protective efficacy of the protein-based vaccines against tuberculosis (TB). Mycobacterial…”
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Mycobacterium tuberculosis Rv3463 induces mycobactericidal activity in macrophages by enhancing phagolysosomal fusion and exhibits therapeutic potential
Published in Scientific reports (12-03-2019)“…Macrophages are responsible for innate and adaptive immune response activation necessary for eliminating infections. Optimal activation of macrophages to…”
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Mycobacterium tuberculosis Rv2882c Protein Induces Activation of Macrophages through TLR4 and Exhibits Vaccine Potential
Published in PloS one (06-10-2016)“…Macrophages constitute the first line of defense against Mycobacterium tuberculosis and are critical in linking innate and adaptive immunity. Therefore, the…”
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Mycobacterial acyl carrier protein suppresses TFEB activation and upregulates miR-155 to inhibit host defense
Published in Frontiers in immunology (28-09-2022)“…Mycobacterial acyl carrier protein (AcpM; Rv2244), a key protein involved in Mycobacterium tuberculosis (Mtb) mycolic acid production, has been shown to…”
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Mycobacterium tuberculosis RpfE-Induced Prostaglandin E2 in Dendritic Cells Induces Th1/Th17 Cell Differentiation
Published in International journal of molecular sciences (14-07-2021)“…Prostaglandin E2 (PGE2) is an important biological mediator involved in the defense against Mycobacterium tuberculosis (Mtb) infection. Currently, there are no…”
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Antigen-Specific IFN-γ/IL-17-Co-Producing CD4+ T-Cells are the Determinants for Protective Efficacy of Tuberculosis Subunit Vaccine
Published in Vaccines (Basel) (11-06-2020)“…The antigen-specific Th17 responses in the lungs for improved immunity against Mycobacterium tuberculosis (Mtb) infection are incompletely understood…”
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A Dendritic Cell-Activating Rv1876 Protein Elicits Mycobacterium Bovis BCG-Prime Effect via Th1-Immune Response
Published in Biomolecules (Basel, Switzerland) (03-09-2021)“…The widely administered tuberculosis (TB) vaccine, Bacillus Calmette-Guerin (BCG), is the only licensed vaccine, but has highly variable efficiency against…”
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Mycobacterium tuberculosis Protein Rv3841 Activates Dendritic Cells and Contributes to a T Helper 1 Immune Response
Published in Journal of immunology research (01-01-2018)“…The attenuated vaccine Mycobacterium bovis BCG (Bacille Calmette Guerin) has limited protective efficacy against TB. The development of more effective TB…”
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Mycobacterium avium MAV2052 protein induces apoptosis in murine macrophage cells through Toll-like receptor 4
Published in Apoptosis (London) (01-04-2016)“…Mycobacterium avium and its sonic extracts induce apoptosis in macrophages. However, little is known about the M. avium components regulating macrophage…”
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Fusion of Dendritic Cells Activating Rv2299c Protein Enhances the Protective Immunity of Ag85B-ESAT6 Vaccine Candidate against Tuberculosis
Published in Pathogens (Basel) (22-10-2020)“…In Mycobacterium tuberculosis infection, naïve T cells that encounter mycobacterial antigens through dendritic cells (DCs) induce various CD4+ T-cell…”
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Mycobacterium tuberculosis Rv2005c Induces Dendritic Cell Maturation and Th1 Responses and Exhibits Immunotherapeutic Activity by Fusion with the Rv2882c Protein
Published in Vaccines (Basel) (10-07-2020)“…Immunotherapy represents a promising approach for improving current antibiotic treatments through the engagement of the host’s immune system…”
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T-Cell Death-Associated Gene 51 Is a Novel Negative Regulator of PPARγ That Inhibits PPARγ-RXRα Heterodimer Formation in Adipogenesis
Published in Molecules and cells (2021)“…The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is the master transcriptional regulator in adipogenesis. PPARγ forms a heterodimer…”
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D-chiro-inositol Negatively Regulates the Formation of Multinucleated Osteoclasts by Down-Regulating NFATc1
Published in Journal of clinical immunology (01-12-2012)“…Purpose Osteoclasts (OCs) are multinucleated giant cells that resorb bone matrix. Accelerated bone destruction by OCs might cause several metabolic…”
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Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene
Published in Biochemical and biophysical research communications (30-11-2007)“…Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are key adaptor molecules in the TNFR-signaling complexes that promote a wide variety of…”
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Recombinant Rv3261 protein of Mycobacterium tuberculosis induces apoptosis through a mitochondrion-dependent pathway in macrophages and inhibits intracellular bacterial growth
Published in Cellular immunology (01-08-2020)“…•Rv3261 induces macrophage apoptosis via caspase-3/-9 through interaction with TLR4.•Rv3261 induced loss of mitochondrial transmembrane potential…”
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Mycobacterium tuberculosis acyl carrier protein inhibits macrophage apoptotic death by modulating the reactive oxygen species/c-Jun N-terminal kinase pathway
Published in Microbes and infection (01-01-2019)“…Mycobacterial acyl carrier protein (AcpM; Rv2244) is a meromycolate extension acyl carrier protein of Mycobacterium tuberculosis (Mtb), which participates in…”
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