Search Results - "Choi, Seung H"

CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability by Choi, Seung H, Martinez, Thomas F, Kim, Seongjae, Donaldson, Cynthia, Shokhirev, Maxim N, Saghatelian, Alan, Jones, Katherine A

“…The RNA polymerase II (RNAPII) C-terminal domain kinase, CDK12, regulates genome stability, expression of DNA repair genes, and cancer cell resistance to…”
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Structural basis for transcriptional start site control of HIV-1 RNA fate by Brown, Joshua D, Kharytonchyk, Siarhei, Chaudry, Issac, Iyer, Aishwarya S, Carter, Hannah, Becker, Ghazal, Desai, Yash, Glang, Lindsay, Choi, Seung H, Singh, Karndeep, Lopresti, Michael W, Orellana, Matthew, Rodriguez, Tatiana, Oboh, Ubiomo, Hijji, Jana, Ghinger, Frances Grace, Stewart, Kailan, Francis, Dillion, Edwards, Bryce, Chen, Patrick, Case, David A, Telesnitsky, Alice, Summers, Michael F

“…Heterogeneous transcriptional start site usage by HIV-1 produces 5'-capped RNAs beginning with one, two, or three 5'-guanosines ( 1G, 2G, or 3G, respectively)…”
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Evidence for a Pan-Neurodegenerative Disease Response in Huntington's and Parkinson's Disease Expression Profiles by Labadorf, Adam, Choi, Seung H, Myers, Richard H

“…Huntington's and Parkinson's Diseases (HD and PD) are neurodegenerative disorders that share some pathological features but are disparate in others. For…”
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Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells by Choi, Seung H, Wright, Jason B, Gerber, Scott A, Cole, Michael D

“…Rapid Myc protein turnover is critical for maintaining basal levels of Myc activity in normal cells and a prompt response to changing growth signals. We…”
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A potentially abundant junctional RNA motif stabilized by m6A and Mg2 by Liu, Bei, Merriman, Dawn K., Choi, Seung H., Schumacher, Maria A., Plangger, Raphael, Kreutz, Christoph, Horner, Stacy M., Meyer, Kate D., Al-Hashimi, Hashim M.

“…N 6 -Methyladenosine (m 6 A) is an abundant post-transcriptional RNA modification that influences multiple aspects of gene expression. In addition to…”
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Acetylation takes aim at mRNA by Choi, Seung H., Meyer, Kate D.

“…Recent advances in the ability to detect mRNA base modifications have led to a renewed appreciation for the diversity of the epitranscriptome and its ability…”
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Targeted Disruption of Myc–Max Oncoprotein Complex by a Small Molecule by Choi, Seung H, Mahankali, Madhupriya, Lee, Sang Jun, Hull, Mitchell, Petrassi, H. Michael, Chatterjee, Arnab K, Schultz, Peter G, Jones, Katherine A, Shen, Weijun

“…Myc plays important roles in cell cycle progression, cell growth, and stem cell self-renewal. Although dysregulation of Myc expression is a hallmark of human…”
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α-Catenin interacts with APC to regulate β-catenin proteolysis and transcriptional repression of Wnt target genes by Choi, Seung H, Estarás, Conchi, Moresco, James J, Yates, 3rd, John R, Jones, Katherine A

“…Mutation of the adenomatous polyposis coli (APC) tumor suppressor stabilizes β-catenin and aberrantly reactivates Wnt/β-catenin target genes in colon cancer…”
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Robust IR‐based detection of stable and fractionally populated G‐C+ and A‐T Hoogsteen base pairs in duplex DNA by Stelling, Allison L., Xu, Yu, Zhou, Huiqing, Choi, Seung H., Clay, Mary C., Merriman, Dawn K., Al‐Hashimi, Hashim M.

“…Noncanonical G‐C+ and A‐T Hoogsteen base pairs can form in duplex DNA and play roles in recognition, damage repair, and replication. Identifying Hoogsteen base…”
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RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs by Choi, Seung H., Flamand, Mathieu N., Liu, Bei, Zhu, Huanyu, Hu, Meghan, Wang, Melanie, Sewell, Jonathon, Holley, Christopher L., Al-Hashimi, Hashim M., Meyer, Kate D.

“…N6-methyladenosine (m6A) is deposited co-transcriptionally on thousands of cellular mRNAs and plays important roles in mRNA processing and cellular function…”
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Systematic dissection, preservation, and multiomics in whole human and bovine hearts by Moreira, Jesse D., Gower, Adam C., Xue, Liying, Alekseyev, Yuriy, Smith, Karan K., Choi, Seung H., Ayalon, Nir, Farb, Melissa G., Tenan, Kenneth, LeClerc, Ashley, Levy, Daniel, Benjamin, Emelia J., Lenburg, Marc E., Mitchell, Richard N., Padera, Robert F., Fetterman, Jessica L., Gopal, Deepa M.

“…•RNA and metabolite integrity are largely preserved up to 12 hours postmortem in cardiac samples.•Cardioplegic solution storage during the postmortem interval…”
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Respiratory Depression Caused by Remifentanil Infusion for Postoperative Pain Control by Koo, Bon N., Choi, Seung H., Chun, Duk H., Kil, Hae K., Kim, Ki J., Min, Kyeong T., Lee, Sung J.

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A gene-specific role for the Ssu72 RNAPII CTD phosphatase in HIV-1 Tat transactivation by Chen, Yupeng, Zhang, Lirong, Estarás, Conchi, Choi, Seung H, Moreno, Jr, Luis, Karn, Jonathan, Moresco, James J, Yates, 3rd, John R, Jones, Katherine A

“…HIV-1 Tat stimulates transcription elongation by recruiting the P-TEFb (positive transcription elongation factor-b) (CycT1:CDK9) C-terminal domain (CTD) kinase…”
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MDB-38. AN INTEGRATED MODEL FOR RESISTANCE TO BROMODOMAIN INHIBITORS IN CHILDHOOD MEDULLOBLASTOMA by Choi, Seung H, Lupien, Leslie, Boynton, Adam N, Bandopadhayay, Pratiti, Prensner, John R

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Abstract 14272: Whole Exome Sequence Analysis of Pulmonary Hypertension in the UK Biobank by Clapham, Katharine, Pampana, Akhil, Choi, Seung H, Honigberg, Michael, Peloso, Gina, Ellinor, Patrick T, Natarajan, Pradeep

“…IntroductionPulmonary hypertension (PH) is a progressive disease characterized by adverse remodeling of the lung vasculature and right ventricular failure…”
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Abstract 15670: Clinical Relevance of a Polygenic Susceptibility to Dilated Cardiomyopathy by Gaziano, Liam, Biddinger, Kiran, Jurgens, Sean J, Choi, Seung H, Lubitz, Steven A, Ellinor, Patrick T, Aragam, Krishna

“…IntroductionBoth rare and common genetic variants have been associated with dilated cardiomyopathy (DCM), but their contributions to DCM risk in the context of…”
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Comparison of Clinical and Radiologic Results Between Partial Meniscectomy and Refixation of Medial Meniscus Posterior Root Tears: A Minimum 5-Year Follow-up by Chung, Kyu Sung, M.D, Ha, Jeong Ku, M.D, Yeom, Cheol Hyun, M.D, Ra, Ho Jong, M.D, Jang, Ho Su, M.D, Choi, Seung Hyuk, M.D, Kim, Jin Goo, M.D., Ph.D

“…Purpose To compare the clinical and radiologic results of partial meniscectomy with those of refixation in patients with medial meniscus posterior root tears…”
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Abstract 13496: Sequencing in Over 50,000 Cases Identifies Coding and Structural Variation Underlying Atrial Fibrillation Risk by Jurgens, Sean J, Choi, Seung H, Haggerty, Christopher M, Xiao, Ling, Morrill, Valerie N, Marston, Nicholas A, Weng, Lu C, Pirruccello, James P, Hill, Matthew C, Ruff, Christian T, Sabatine, Marc S, Lunetta, Kathryn, Lubitz, Steven A, Ellinor, Patrick T

“…IntroductionAtrial fibrillation (AF) is the most common sustained arrhythmia and is associated with substantial morbidity and mortality. AF is known to have a…”
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Abstract 15276: Polygenic Susceptibility to Dilated Cardiomyopathy Underlies Peripartum, Alcoholic, and Chemotherapy-Induced Cardiomyopathies by Maamari, Dimitri J, Biddinger, Kiran J, Jurgens, Sean J, Gaziano, Liam, Rämö, Joel T, Gongora, Carlos A, Hayes, Dolphurs, Choi, Seung H, Sarma, Amy, Neilan, Tomas G, Khera, Amit V, Ellinor, Patrick T, Aragam, Krishna G

“…IntroductionRare (monogenic) variants linked to dilated cardiomyopathy (DCM) are enriched among individuals with peripartum (PPCM), alcoholic (ACM), and…”
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Abstract B017: Aberrant translation of microproteins as a source of new cancer dependencies in medulloblastoma by Prensner, John, Bandopadhayay, Pratiti, Saha, Soumik, Lupien, Leslie, Choi, Seung H.

“…Abstract A hallmark of high-risk childhood medulloblastoma is the dysregulation of RNA translation.Dysregulation of ribosome activity not only influences known…”
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