Search Results - "Choi, Sangdun"

A Structure-Based Drug Discovery Paradigm by Batool, Maria, Ahmad, Bilal, Choi, Sangdun

“…Structure-based drug design is becoming an essential tool for faster and more cost-efficient lead discovery relative to the traditional method. Genomic,…”
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Recent clinical trends in Toll‐like receptor targeting therapeutics by Anwar, Muhammad Ayaz, Shah, Masaud, Kim, Jason, Choi, Sangdun

“…Toll‐like receptors (TLRs) are germline‐encoded receptors that are central to innate and adaptive immune responses. Owing to their vital role in inflammation,…”
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Toll-like receptor-induced cytokines as immunotherapeutic targets in cancers and autoimmune diseases by Patra, Mahesh Chandra, Shah, Masaud, Choi, Sangdun

“…Immune cells of the myeloid and lymphoid lineages express Toll-like receptors (TLRs) to recognize pathogenic components or cellular debris and activate the…”
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Role of Thioredoxin-Interacting Protein in Diseases and Its Therapeutic Outlook by Qayyum, Naila, Haseeb, Muhammad, Kim, Moon Suk, Choi, Sangdun

“…Thioredoxin-interacting protein (TXNIP), widely known as thioredoxin-binding protein 2 (TBP2), is a major binding mediator in the thioredoxin (TXN) antioxidant…”
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TLR4-Targeting Therapeutics: Structural Basis and Computer-Aided Drug Discovery Approaches by Ain, Qurat Ul, Batool, Maria, Choi, Sangdun

“…The integration of computational techniques into drug development has led to a substantial increase in the knowledge of structural, chemical, and biological…”
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Exploring the Binding Mechanism of PF-07321332 SARS-CoV-2 Protease Inhibitor through Molecular Dynamics and Binding Free Energy Simulations by Ahmad, Bilal, Batool, Maria, Ain, Qurat Ul, Kim, Moon Suk, Choi, Sangdun

“…The novel coronavirus disease, caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), rapidly spreading around the world, poses a major threat to the…”
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Recent progress in the development of Toll-like receptor (TLR) antagonists by Patra, Mahesh Chandra, Choi, Sangdun

“…Pattern recognition receptors (PRRs) of the innate immune system mediate and control the activation and progression of adaptive immunity. Toll-like receptors…”
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The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration by Farooq, Mariya, Khan, Abdul Waheed, Kim, Moon Suk, Choi, Sangdun

“…Fibroblast growth factors (FGFs) are a large family of secretory molecules that act through tyrosine kinase receptors known as FGF receptors. They play crucial…”
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NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders by Ramachandran, Rajath, Manan, Abdul, Kim, Jei, Choi, Sangdun

“…Proinflammatory cytokines and chemokines play a crucial role in regulating the inflammatory response, which is essential for the proper functioning of our…”
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Toll-like receptors: promising therapeutic targets for inflammatory diseases by Achek, Asma, Yesudhas, Dhanusha, Choi, Sangdun

“…The health of living organisms is constantly challenged by bacterial and viral threats. The recognition of pathogenic microorganisms by diverse receptors…”
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CRISPR/Cas System and Factors Affecting Its Precision and Efficiency by Javaid, Nasir, Choi, Sangdun

“…The diverse applications of genetically modified cells and organisms require more precise and efficient genome-editing tool such as clustered regularly…”
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Nanoinformatics: emerging databases and available tools by Panneerselvam, Suresh, Choi, Sangdun

“…Nanotechnology has arisen as a key player in the field of nanomedicine. Although the use of engineered nanoparticles is rapidly increasing, safety assessment…”
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The Roles of the NLRP3 Inflammasome in Neurodegenerative and Metabolic Diseases and in Relevant Advanced Therapeutic Interventions by Pirzada, Rameez Hassan, Javaid, Nasir, Choi, Sangdun

“…Inflammasomes are intracellular multiprotein complexes in the cytoplasm that regulate inflammation activation in the innate immune system in response to…”
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Negative regulatory approaches to the attenuation of Toll-like receptor signaling by Anwar, Muhammad Ayaz, Basith, Shaherin, Choi, Sangdun

“…Toll-like receptors (TLRs) are pivotal components of the innate immune response, which is responsible for eradicating invading microorganisms through the…”
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Mutations in the SARS-CoV-2 spike RBD are responsible for stronger ACE2 binding and poor anti-SARS-CoV mAbs cross-neutralization by Shah, Masaud, Ahmad, Bilal, Choi, Sangdun, Woo, Hyun Goo

“…[Display omitted] Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), is a novel beta coronavirus…”
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Toll-Like Receptors as a Therapeutic Target in the Era of Immunotherapies by Farooq, Mariya, Batool, Maria, Kim, Moon Suk, Choi, Sangdun

“…Toll-like receptors (TLRs) are the pattern recognition receptors, which are activated by foreign and host molecules in order to initiate the immune response…”
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An injectable, click-crosslinked, cytomodulin-modified hyaluronic acid hydrogel for cartilage tissue engineering by Park, Seung Hun, Seo, Ji Young, Park, Joon Yeong, Ji, Yun Bae, Kim, Kyungsook, Choi, Hak Soo, Choi, Sangdun, Kim, Jae Ho, Min, Byoung Hyun, Kim, Moon Suk

“…This is the first report, to our knowledge, of the preparation of an injectable in situ–forming click-crosslinked hyaluronic acid (Cx-HA) hydrogel (Cx-HA-CM)…”
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An Alternate Approach to Generate Induced Pluripotent Stem Cells with Precise CRISPR/Cas9 Tool by Javaid, Nasir, Choi, Sangdun

“…The induced pluripotent stem cells (iPSCs) are considered powerful tools in pharmacology, biomedicine, toxicology, and cell therapy. Multiple approaches have…”
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Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation by Choi, Yong-Min, Kim, Han-Kyul, Shim, Wooyoung, Anwar, Muhammad Ayaz, Kwon, Ji-Woong, Kwon, Hyuk-Kwon, Kim, Hyung Joong, Jeong, Hyobin, Kim, Hwan Myung, Hwang, Daehee, Kim, Hyung Sik, Choi, Sangdun

“…The chemotherapeutic use of cisplatin is limited by its severe side effects. In this study, by conducting different omics data analyses, we demonstrated that…”
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Toll-like Receptor Mediation in SARS-CoV-2: A Therapeutic Approach by Manan, Abdul, Pirzada, Rameez Hassan, Haseeb, Muhammad, Choi, Sangdun

“…The innate immune system facilitates defense mechanisms against pathogen invasion and cell damage. Toll-like receptors (TLRs) assist in the activation of the…”
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