Search Results - "Choi, Jua"

IgG Endopeptidase in Highly Sensitized Patients Undergoing Transplantation by Jordan, Stanley C, Lorant, Tomas, Choi, Jua, Kjellman, Christian, Winstedt, Lena, Bengtsson, Mats, Zhang, Xiaohai, Eich, Torsten, Toyoda, Mieko, Eriksson, Britt-Marie, Ge, Shili, Peng, Alice, Järnum, Sofia, Wood, Kathryn J, Lundgren, Torbjorn, Wennberg, Lars, Bäckman, Lars, Larsson, Erik, Villicana, Rafael, Kahwaji, Joe, Louie, Sabrina, Kang, Alexis, Haas, Mark, Nast, Cynthia, Vo, Ashley, Tufveson, Gunnar

“…In this study, an IgG-degrading enzyme derived from Streptococcus pyogenes (IdeS) that cleaves human IgG into F(ab′) 2 and Fc fragments reduced or eliminated…”
Get full text

A phase I/II, double‐blind, placebo‐controlled study assessing safety and efficacy of C1 esterase inhibitor for prevention of delayed graft function in deceased donor kidney transplant recipients by Jordan, Stanley C., Choi, Jua, Aubert, Olivier, Haas, Mark, Loupy, Alexandre, Huang, Edmund, Peng, Alice, Kim, Irene, Louie, Sabrina, Ammerman, Noriko, Najjar, Reiad, Puliyanda, Dechu, Vo, Ashley

“…Delayed graft function (DGF) is defined as need for dialysis early posttransplant. DGF is related to ischemia–reperfusion injury (IRI) that diminishes…”
Get full text

Differences in pathologic features and graft outcomes in antibody-mediated rejection of renal allografts due to persistent/recurrent versus de novo donor-specific antibodies by Haas, Mark, Mirocha, James, Reinsmoen, Nancy L, Vo, Ashley A, Choi, Jua, Kahwaji, Joseph M, Peng, Alice, Villicana, Rafael, Jordan, Stanley C

“…Antibody-mediated rejection (ABMR) of renal allografts occurs in two forms. Type 1 ABMR results from persistence and/or a rebound of preexisting donor-specific…”
Get more information

A Phase I/II Placebo-Controlled Trial of C1-Inhibitor for Prevention of Antibody-Mediated Rejection in HLA Sensitized Patients by Vo, Ashley A, Zeevi, Adriana, Choi, Jua, Cisneros, Kristen, Toyoda, Mieko, Kahwaji, Joseph, Peng, Alice, Villicana, Rafael, Puliyanda, Dechu, Reinsmoen, Nancy, Haas, Mark, Jordan, Stanley C

“…BACKGROUNDAntibody-mediated rejection (AMR) is a severe form of rejection, mediated primarily by antibody-dependent complement (C) activation. C1 inhibitor…”
Get full text

Three-Year Outcomes of a Randomized, Double-Blind, Placebo-Controlled Study Assessing Safety and Efficacy of C1 Esterase Inhibitor for Prevention of Delayed Graft Function in Deceased Donor Kidney Transplant Recipients by Huang, Edmund, Vo, Ashley, Choi, Jua, Ammerman, Noriko, Lim, Kathlyn, Sethi, Supreet, Kim, Irene, Kumar, Sanjeev, Najjar, Reiad, Peng, Alice, Jordan, Stanley C

“…Delayed graft function is related to ischemia-reperfusion injury and may be complement dependent. We previously reported from a randomized, placebo-controlled…”
Get full text

Desensitization: Overcoming the Immunologic Barriers to Transplantation by Peng, Alice, Vo, Ashley, Toyoda, Mieko, Choi, Jua, Sethi, Supreet, Jordan, Stanley C.

“…HLA (Human Leucocyte Antigen) sensitization is a significant barrier to successful kidney transplantation. It often translates into difficult crossmatch before…”
Get full text

Kidney transplantation in highly sensitized patients by Jordan, Stanley C, Choi, Jua, Vo, Ashley

“…Desensitization, a term loosely referring to a collection of antibody reduction and B-cell depletional therapies aimed at improving rates of transplantation in…”
Get full text

The role of novel therapeutic approaches for prevention of allosensitization and antibody‐mediated rejection by Jordan, Stanley C., Ammerman, Noriko, Choi, Jua, Huang, Edmund, Peng, Alice, Sethi, Supreet, Najjar, Reiad, Kim, Irene, Toyoda, Mieko, Kumar, Sanjeev, Lim, Kathlyn, Vo, Ashley

“…Modification of pathogenic antibodies and their effector functions in autoimmune diseases or use of B cell/plasma cell‐directed anticancer therapies have…”
Get full text

Impact of Desensitization on Antiviral Immunity in HLA-Sensitized Kidney Transplant Recipients by Petrosyan, Anna, Vo, Ashley, Choi, Jua, Peng, Alice, Kahwaji, Joseph, Jordan, Stanley C., Chao, Christine, Rodriguez, Edgar, Chu, Maggie, Thomas, David, Mirocha, James, Ge, Shili, Shin, Bong-Ha, Toyoda, Mieko, Galera, Odette A.

“…Viral infections represent significant morbidity and mortality factors in kidney transplant recipients, with CMV, EBV, and BKV infections being most common…”
Get full text

A Phase I/II Trial of the Interleukin-6 Receptor–Specific Humanized Monoclonal (Tocilizumab) + Intravenous Immunoglobulin in Difficult to Desensitize Patients by Vo, Ashley A, Choi, Jua, Kim, Irene, Louie, Sabrina, Cisneros, Kristen, Kahwaji, Joseph, Toyoda, Mieko, Ge, Shili, Haas, Mark, Puliyanda, Dechu, Reinsmoen, Nancy, Peng, Alice, Villicana, Rafael, Jordan, Stanley C

“…BACKGROUNDCurrent desensitization (DES) methods are not always effective. Thus, novel, more effective approaches are desirable. Interleukin (IL)-6 is an…”
Get full text

Interleukin-6, A Cytokine Critical to Mediation of Inflammation, Autoimmunity and Allograft Rejection: Therapeutic Implications of IL-6 Receptor Blockade by Jordan, Stanley C, Choi, Jua, Kim, Irene, Wu, Gordon, Toyoda, Mieko, Shin, Bonga, Vo, Ashley

“…ABSTRACTThe success of kidney transplants is limited by the lack of robust improvements in long-term survival. It is now recognized that alloimmune responses…”
Get full text

Interleukin-6: An Important Mediator of Allograft Injury by Jordan, Stanley C., Ammerman, Noriko, Choi, Jua, Kumar, Sanjeev, Huang, Edmund, Toyoda, Mieko, Kim, Irene, Wu, Gordon, Vo, Ashley

“…Interleukin-6 (IL-6) is a cytokine with critical innate and adaptive immunity functions. Its diverse immunological and physiological actions include direction…”
Get full text

Imlifidase Inhibits HLA Antibody-mediated NK Cell Activation and Antibody-dependent Cell-mediated Cytotoxicity (ADCC) In Vitro by Ge, Shili, Chu, Maggie, Choi, Jua, Louie, Sabrina, Vo, Ashley, Jordan, Stanley C., Toyoda, Mieko

“…BACKGROUND:Antibody-dependent cell-mediated cytotoxicity (ADCC) is an important pathway responsible for antibody-mediated rejection (AMR). Imlifidase (IdeS)…”
Get full text

Reply to: IgG Endopeptidase in Highly Sensitized Patients Undergoing Transplantation by Jordan, Stanley C., Lorant, Tomas, Choi, Jua

Get full text

Outcomes of Conversion From Calcineurin Inhibitor to Belatacept-based Immunosuppression in HLA-sensitized Kidney Transplant Recipients by Sethi, Supreet, Najjar, Reiad, Peng, Alice, Choi, Jua, Lim, Kathlyn, Vo, Ashley, Jordan, Stanley C., Huang, Edmund

“…BACKGROUND.The efficacy and safety of belatacept when converted from calcineurin inhibitors (CNI) in HLA-sensitized (HS) kidney transplant recipients has not…”
Get full text

Factors Predicting Risk for Antibody-mediated Rejection and Graft Loss in Highly Human Leukocyte Antigen Sensitized Patients Transplanted After Desensitization by Vo, Ashley A, Sinha, Aditi, Haas, Mark, Choi, Jua, Mirocha, James, Kahwaji, Joseph, Peng, Alice, Villicana, Rafael, Jordan, Stanley C

“…BACKGROUNDDesensitization with intravenous immunoglobulin and rituximab (I+R) significantly improves transplant rates in highly sensitized patients, but…”
Get full text

Benefits of Rituximab Combined With Intravenous Immunoglobulin for Desensitization in Kidney Transplant Recipients by Vo, Ashley A, Choi, Jua, Cisneros, Kristen, Reinsmoen, Nancy, Haas, Mark, Ge, Shili, Toyoda, Mieko, Kahwaji, Joseph, Peng, Alice, Villicana, Rafael, Jordan, Stanley C

“…BACKGROUNDHighly HLA-sensitized (HS) patients have difficulty accessing compatible donors, especially deceased donor (DD) transplants. Desensitization…”
Get full text

Novel Therapeutic Approaches to Allosensitization and Antibody-mediated Rejection by Jordan, Stanley C, Ammerman, Noriko, Choi, Jua, Huang, Edmund, Peng, Alice, Sethi, Supreet, Najjar, Reiad, Toyoda, Mieko, Lim, Kathlyn, Louie, Sabrina, Vo, Ashley

“…ABSTRACTModification of pathogenic antibodies for autoimmune diseases illuminated the biologic relevance of B cells, plasma cells, and pathogenic antibodies in…”
Get full text

Clazakizumab for desensitization in highly sensitized patients awaiting transplantation by Vo, Ashley A., Huang, Edmund, Ammerman, Noriko, Toyoda, Mieko, Ge, Shili, Haas, Mark, Zhang, Xiaohai, Peng, Alice, Najjar, Reiad, Williamson, Summer, Myers, Catherine, Sethi, Supreet, Lim, Kathlyn, Choi, Jua, Gillespie, Matthew, Tang, Jacqueline, Jordan, Stanley C.

“…Alloantibodies are a significant barrier to successful transplantation. While desensitization has emerged, efficacy is limited. Interleukin‐6 (IL‐6) is an…”
Get full text

Clinical Relevance of Posttransplant DSAs in Patients Receiving Desensitization for HLA-incompatible Kidney Transplantation by Vo, Ashley A., Aubert, Olivier, Haas, Mark, Huang, Edmund, Zhang, Xiaohai, Choi, Jua, Peng, Alice, Najjar, Reiad, Sethi, Supreet, Ammerman, Nori, Lim, Kathlyn, Jordan, Stanley C.

“…BACKGROUND.Highly HLA-sensitized (HS) patients have an increased risk for the development of donor-specific antibodies (DSA) and antibody-mediated rejection…”
Get full text