Search Results - "Choi, Issac"

Location bias contributes to functionally selective responses of biased CXCR3 agonists by Eiger, Dylan Scott, Boldizsar, Noelia, Honeycutt, Christopher Cole, Gardner, Julia, Kirchner, Stephen, Hicks, Chloe, Choi, Issac, Pham, Uyen, Zheng, Kevin, Warman, Anmol, Smith, Jeffrey S., Zhang, Jennifer Y., Rajagopal, Sudarshan

“…Some G protein-coupled receptor (GPCR) ligands act as “biased agonists” that preferentially activate specific signaling transducers over others. Although GPCRs…”
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march5 Governs the Convergence and Extension Movement for Organization of the Telencephalon and Diencephalon in Zebrafish Embryos by Jung, Jangham, Choi, Issac, Ro, Hyunju, Huh, Tae-Lin, Choe, Joonho, Rhee, Myungchull

“…MARCH5 is a RING finger E3 ligase involved in mitochondrial integrity, cellular protein homeostasis, and the regulation of mitochondrial fusion and fission. To…”
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Beta-Arrestins and Receptor Signaling in the Vascular Endothelium by Lee, Claudia, Viswanathan, Gayathri, Choi, Issac, Jassal, Chanpreet, Kohlmann, Taylor, Rajagopal, Sudarshan

“…The vascular endothelium is the innermost layer of blood vessels and is a key regulator of vascular tone. Endothelial function is controlled by receptor…”
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march5 Governs the Convergence and Extension Movement for Organization of the Telencephalon and Diencephalon in Zebrafish Embryos by Jung, Jangham, Choi, Issac, Ro, Hyunju, Huh, Tae-Lin, Choe, Joonho, Rhee, Myungchull

“…MARCH5 is a RING finger E3 ligase involved in mitochondrial integrity, cellular protein homeostasis, and the regulation of mitochondrial fusion and fission. To…”
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Znf76 is associated with development of the eyes, midbrain, MHB, and hindbrain in zebrafish embryos by Jung, Jangham, Udhaya Kumar, S., Choi, Issac, Huh, Tea-Lin, Rhee, Myungchull

“…ZNF76 is a transcriptional repressor that targets the TATA-binding protein (TBP) and plays an essential role during brain development; however, its function…”
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Single-Cell Analysis Reveals Distinct Immune and Smooth Muscle Cell Populations that Contribute to Chronic Thromboembolic Pulmonary Hypertension by Viswanathan, Gayathri, Kirshner, Hélène Fradin, Nazo, Nour, Ali, Saba, Ganapathi, Asvin, Cumming, Ian, Zhuang, Yonghua, Choi, Issac, Warman, Anmol, Jassal, Chanpreet, Almeida-Peters, Susana, Haney, John, Corcoran, David, Yu, Yen-Rei, Rajagopal, Sudarshan

“…Chronic thromboembolic pulmonary hypertension (CTEPH) is a sequela of acute pulmonary embolism (PE) in which the PE remodels into a chronic scar in the…”
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Differential GRK Recruitment and the Phosphorylation Barcode as a Mechanism for Biased Agonism at G Protein‐Coupled Receptors by Gardner, Julia, Eiger, Dylan, Honeycutt, Christopher, Boldizsar, Noelia, Choi, Issac, Rajagopal, Sudarshan

“…G Protein‐Coupled Receptors (GPCRs) are the largest and most diverse family of cell receptors in the human genome and account for ~30% of all FDA‐approved…”
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Location Bias of G Protein‐Coupled Receptor Kinases Promotes Biased Signaling at CXCR3 by Hicks, Chloe N., Eiger, Dylan, Gardner, Julia, Boldizsar, Noelia, Honeycutt, Cole, Choi, Issac, Rajagopal, Sudarshan

“…G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors and are known to canonically signal through two main effector proteins: G…”
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Location Bias Contributes to Functionally Selective Responses of Biased CXCR3 Agonists to Regulate Inflammation by Gardner, Julia, Eiger, Dylan, Boldizsar, Noelia, Honeycutt, Christopher C., Kirchner, Stephen, Hicks, Chloe, Choi, Issac, Zheng, Kevin, Warman, Anmol, Smith, Jeffrey, Zhang, Jennifer, Rajagopal, Sudarshan

“…G Protein‐Coupled Receptors (GPCRs) represent the largest and most diverse family of cell receptors in the human genome and are targeted by ~35% of all…”
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Phosphorylation barcodes direct biased chemokine signaling at CXCR3 by Eiger, Dylan S, Smith, Jeffrey S, Shi, Tujin, Stepniewski, Tomasz Maciej, Tsai, Chia-Feng, Honeycutt, Christopher, Boldizsar, Noelia, Gardner, Julia, Nicora, Carrie D, Moghieb, Ahmed M, Kawakami, Kouki, Choi, Issac, Hicks, Chloe, Zheng, Kevin, Warman, Anmol, Alagesan, Priya, Knape, Nicole M, Huang, Ouwen, Silverman, Justin D, Smith, Richard D, Inoue, Asuka, Selent, Jana, Jacobs, Jon M, Rajagopal, Sudarshan

“…G protein-coupled receptor (GPCR)-biased agonism, selective activation of certain signaling pathways relative to others, is thought to be directed by…”
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Biased agonists of the chemokine receptor CXCR3 differentially drive formation of Gαi and β‐arrestin complexes by Zheng, Kevin, Smith, Jeffrey S., Choi, Issac, Warman, Anmol, Gundry, Jaimee N., Pack, Thomas F., Inoue, Asuka, Caron, Marc, Rajagopal, Sudarshan

“…Abstract only G‐protein‐coupled receptors (GPCRs) are the most common cell surface receptor class and influence nearly every biological process within a cell…”
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β-Arrestin–Mediated Angiotensin II Type 1 Receptor Activation Promotes Pulmonary Vascular Remodeling in Pulmonary Hypertension by Ma, Zhiyuan, Viswanathan, Gayathri, Sellig, Mason, Jassal, Chanpreet, Choi, Issac, Garikipati, Aditi, Xiong, Xinyu, Nazo, Nour, Rajagopal, Sudarshan

“…[Display omitted] •We tested the effects of a β-arrestin–biased agonist (TRV023) of the angiotensin II (AngII) type 1 receptor (AT1R), which acts as a…”
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Biased agonists of the chemokine receptor CXCR3 differentially signal through Gα i :β-arrestin complexes by Zheng, Kevin, Smith, Jeffrey S, Eiger, Dylan S, Warman, Anmol, Choi, Issac, Honeycutt, Christopher C, Boldizsar, Noelia, Gundry, Jaimee N, Pack, Thomas F, Inoue, Asuka, Caron, Marc G, Rajagopal, Sudarshan

“…G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors and signal through the proximal effectors, G proteins and β-arrestins, to…”
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Differential beta‐coronavirus infection dynamics in human bronchial epithelial organoids by Park, Dongbin, Kim, Se‐Mi, Jang, Hobin, Kim, Kanghee, Ji, Ho young, Yang, Heedong, Kwon, Woohyun, Kang, Yeonglim, Hwang, Suhee, Kim, Hyunjoon, Casel, Mark Anthony B., Choi, Issac, Yang, Jeong‐Sun, Lee, Joo‐Yeon, Choi, Young Ki

“…The lower respiratory system serves as the target and barrier for beta‐coronavirus (beta‐CoV) infections. In this study, we explored beta‐CoV infection…”
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Phosphorylation barcode ensembles encoded by biased CXCR3 agonists direct non‐redundant chemokine signaling by Eiger, Dylan S., Smith, Jeffrey, Shi, Tujin, Stepniewski, Tomasz M., Honeycutt, Christopher, Boldizsar, Noelia, Gardner, Julia, Tsai, Chia‐Feng, Nicora, Carrie, Moghieb, Ahmed, Kawakami, Kouki, Choi, Issac, Smith, Richard, Inoue, Asuka, Selent, Jana, Jacobs, Jon, Rajagopal, Sudarshan

“…Chemokine receptors, a group of G protein‐coupled receptors (GPCRs), interact with transducers such as G proteins, β‐arrestins, and GPCR kinases (GRKs). In the…”
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Noncanonical scaffolding of G αi and β-arrestin by G protein-coupled receptors by Smith, Jeffrey S, Pack, Thomas F, Inoue, Asuka, Lee, Claudia, Zheng, Kevin, Choi, Issac, Eiger, Dylan S, Warman, Anmol, Xiong, Xinyu, Ma, Zhiyuan, Viswanathan, Gayathri, Levitan, Ian M, Rochelle, Lauren K, Staus, Dean P, Snyder, Joshua C, Kahsai, Alem W, Caron, Marc G, Rajagopal, Sudarshan

“…Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) are common drug targets and canonically couple to specific G protein…”
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