Search Results - "Choi, Harry M T"

Third-generation in situ hybridization chain reaction: multiplexed, quantitative, sensitive, versatile, robust by Choi, Harry M T, Schwarzkopf, Maayan, Fornace, Mark E, Acharya, Aneesh, Artavanis, Georgios, Stegmaier, Johannes, Cunha, Alexandre, Pierce, Niles A

“…hybridization based on the mechanism of the hybridization chain reaction (HCR) has addressed multi-decade challenges that impeded imaging of mRNA expression in…”
Get full text

Next-Generation in Situ Hybridization Chain Reaction: Higher Gain, Lower Cost, Greater Durability by Choi, Harry M. T, Beck, Victor A, Pierce, Niles A

“…Hybridization chain reaction (HCR) provides multiplexed, isothermal, enzyme-free, molecular signal amplification in diverse settings. Within intact vertebrate…”
Get full text

Programming biomolecular self-assembly pathways by Pierce, Niles A, Yin, Peng, Choi, Harry M. T, Calvert, Colby R

“…In nature, self-assembling and disassembling complexes of proteins and nucleic acids bound to a variety of ligands perform intricate and diverse dynamic…”
Get full text

Programmable in situ amplification for multiplexed imaging of mRNA expression by Pierce, Niles A, Choi, Harry M T, Chang, Joann Y, Trinh, Le A, Padilla, Jennifer E, Fraser, Scott E

“…In situ hybridization methods enable the mapping of mRNA expression within intact biological samples. With current approaches, it is challenging to…”
Get full text

Programming DNA Tube Circumferences by Yin, Peng, Hariadi, Rizal F, Sahu, Sudheer, Choi, Harry M.T, Park, Sung Ha, LaBean, Thomas H, Reif, John H

“…Synthesizing molecular tubes with monodisperse, programmable circumferences is an important goal shared by nanotechnology, materials science, and…”
Get full text

Single-molecule RNA detection at depth by hybridization chain reaction and tissue hydrogel embedding and clearing by Shah, Sheel, Lubeck, Eric, Schwarzkopf, Maayan, He, Ting-Fang, Greenbaum, Alon, Sohn, Chang Ho, Lignell, Antti, Choi, Harry M T, Gradinaru, Viviana, Pierce, Niles A, Cai, Long

“…Accurate and robust detection of mRNA molecules in thick tissue samples can reveal gene expression patterns in single cells within their native environment…”
Get full text

Multidimensional quantitative analysis of mRNA expression within intact vertebrate embryos by Trivedi, Vikas, Choi, Harry M T, Fraser, Scott E, Pierce, Niles A

“…For decades, hybridization methods have been essential tools for studies of vertebrate development and disease, as they enable qualitative analyses of mRNA…”
Get full text

Localizing transcripts to single cells suggests an important role of uncultured deltaproteobacteria in the termite gut hydrogen economy by Rosenthal, Adam Z., Zhang, Xinning, Lucey, Kaitlyn S., Ottesen, Elizabeth A., Trivedi, Vikas, Choi, Harry M. T., Pierce, Niles A., Leadbetter, Jared R.

“…Identifying microbes responsible for particular environmental functions is challenging, given that most environments contain an uncultivated microbial…”
Get full text

Integrating DNA strand-displacement circuitry with DNA tile self-assembly by Zhang, David Yu, Hariadi, Rizal F., Choi, Harry M.T., Winfree, Erik

“…DNA nanotechnology has emerged as a reliable and programmable way of controlling matter at the nanoscale through the specificity of Watson–Crick base pairing,…”
Get full text

Hybridization chain reaction enables a unified approach to multiplexed, quantitative, high-resolution immunohistochemistry and in situ hybridization by Schwarzkopf, Maayan, Liu, Mike C, Schulte, Samuel J, Ives, Rachel, Husain, Naeem, Choi, Harry M T, Pierce, Niles A

“…RNA in situ hybridization based on the mechanism of the hybridization chain reaction (HCR) enables multiplexed, quantitative, high-resolution RNA imaging in…”
Get full text

Topological constraints in nucleic acid hybridization kinetics by Bois, Justin S., Venkataraman, Suvir, Choi, Harry M. T., Spakowitz, Andrew J., Wang, Zhen-Gang, Pierce, Niles A.

“…A theoretical examination of kinetic mechanisms for forming knots and links in nucleic acid structures suggests that molecules involving base pairs between…”
Get full text

Mapping a multiplexed zoo of mRNA expression by Choi, Harry M T, Calvert, Colby R, Husain, Naeem, Huss, David, Barsi, Julius C, Deverman, Benjamin E, Hunter, Ryan C, Kato, Mihoko, Lee, S Melanie, Abelin, Anna C T, Rosenthal, Adam Z, Akbari, Omar S, Li, Yuwei, Hay, Bruce A, Sternberg, Paul W, Patterson, Paul H, Davidson, Eric H, Mazmanian, Sarkis K, Prober, David A, van de Rijn, Matt, Leadbetter, Jared R, Newman, Dianne K, Readhead, Carol, Bronner, Marianne E, Wold, Barbara, Lansford, Rusty, Sauka-Spengler, Tatjana, Fraser, Scott E, Pierce, Niles A

“…In situ hybridization methods are used across the biological sciences to map mRNA expression within intact specimens. Multiplexed experiments, in which…”
Get full text

Multiplexed Quantitative In Situ Hybridization with Subcellular or Single-Molecule Resolution Within Whole-Mount Vertebrate Embryos: qHCR and dHCR Imaging (v3.0) by Choi, Harry M T, Schwarzkopf, Maayan, Pierce, Niles A

“…In situ hybridization based on the mechanism of hybridization chain reaction (HCR) enables multiplexed quantitative mRNA imaging in the anatomical context of…”
Get more information

Multiplexed Quantitative In Situ Hybridization for Mammalian Cells on a Slide: qHCR and dHCR Imaging (v3.0) by Schwarzkopf, Maayan, Choi, Harry M T, Pierce, Niles A

“…In situ hybridization based on the mechanism of hybridization chain reaction (HCR) enables multiplexed quantitative mRNA imaging in diverse sample types…”
Get more information

Multiplexed Quantitative In Situ Hybridization for Mammalian or Bacterial Cells in Suspension: qHCR Flow Cytometry (v3.0) by Schwarzkopf, Maayan, Choi, Harry M T, Pierce, Niles A

“…In situ hybridization based on the mechanism of hybridization chain reaction (HCR) enables high-throughput expression profiling of mammalian or bacterial cells…”
Get more information

Multiplexed in situ hybridization using hybridization chain reaction by Choi, Harry M T, Beck, Victor A, Pierce, Niles A

Get more information

Combinatorial analysis of mRNA expression patterns in mouse embryos using hybridization chain reaction by Huss, David, Choi, Harry M T, Readhead, Carol, Fraser, Scott E, Pierce, Niles A, Lansford, Rusty

“…Multiplexed fluorescent hybridization chain reaction (HCR) and advanced imaging techniques can be used to evaluate combinatorial gene expression patterns in…”
Get more information