Search Results - "Choi, Christopher J."

Mode of action and human relevance of THF-induced mouse liver tumors by Choi, Christopher J., Rushton, Erik K., Vardy, Audrey, Higgins, Larry, Augello, Andrea, Parod, Ralph J.

“…•THF is a weak, non-genotoxic liver carcinogen in mice.•THF increases proliferation and CAR-related P450 activities in mouse hepatocytes.•THF does not induce…”
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Interaction of metals with prion protein: Possible role of divalent cations in the pathogenesis of prion diseases by Choi, Christopher J., Kanthasamy, Arthi, Anantharam, Vellareddy, Kanthasamy, Anumantha G.

“…Prion diseases are fatal neurodegenerative disorders that affect both humans and animals. The rapid clinical progression, change in protein conformation,…”
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Manganese Upregulates Cellular Prion Protein and Contributes to Altered Stabilization and Proteolysis: Relevance to Role of Metals in Pathogenesis of Prion Disease by Choi, Christopher J., Anantharam, Vellareddy, Martin, Dustin P., Nicholson, Eric M., Richt, Jürgen A., Kanthasamy, Arthi, Kanthasamy, Anumantha G.

“…Prion diseases are fatal neurodegenerative diseases resulting from misfolding of normal cellular prion (PrPC) into an abnormal form of scrapie prion (PrPSc)…”
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Tyrosine Phosphorylation Regulates the Proteolytic Activation of Protein Kinase Cδ in Dopaminergic Neuronal Cells by Kaul, Siddharth, Anantharam, Vellareddy, Yang, Yongjie, Choi, Christopher J., Kanthasamy, Arthi, Kanthasamy, Anumantha G.

“…Oxidative stress is a key apoptotic stimulus in neuronal cell death and has been implicated in the pathogenesis of many neurodegenerative disorders, including…”
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Normal Cellular Prion Protein Protects against Manganese-Induced Oxidative Stress and Apoptotic Cell Death by Choi, Christopher J., Anantharam, Vellareddy, Saetveit, Nathan J., Houk, Robert S., Kanthasamy, Arthi, Kanthasamy, Anumantha G.

“…The normal prion protein is abundantly expressed in the central nervous system, but its biological function remains unclear. The prion protein has octapeptide…”
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Opposing roles of prion protein in oxidative stress- and ER stress-induced apoptotic signaling by Anantharam, Vellareddy, Kanthasamy, Arthi, Choi, Christopher J., Martin, Dustin P., Latchoumycandane, Calivarathan, Richt, Jüergen A., Kanthasamy, Anumantha G.

“…Although the prion protein is abundantly expressed in the CNS, its biological functions remain unclear. To determine the endogenous function of the cellular…”
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Opposing Role of Prion Protein in Oxidative Stress- and ER Stress-induced Apoptotic Signaling by Anantharam, Vellareddy, Kanthasamy, Arthi, Choi, Christopher J, Martin, Dustin P, Latchoumycandane, Calivarathan, Richt, Jüergen A., Kanthasamy, Anumantha G.

“…Although the prion protein is abundantly expressed in the CNS, its biological functions remain unclear. To determine the endogenous function of the cellular…”
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Tyrosine phosphorylation regulates the proteolytic activation of protein kinase Cdelta in dopaminergic neuronal cells by Kaul, Siddharth, Anantharam, Vellareddy, Yang, Yongjie, Choi, Christopher J, Kanthasamy, Arthi, Kanthasamy, Anumantha G

“…Oxidative stress is a key apoptotic stimulus in neuronal cell death and has been implicated in the pathogenesis of many neurodegenerative disorders, including…”
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Tyrosine Phosphorylation Regulates the Proteolytic Activation of Protein Kinase Cδ in Dopaminergic Neuronal Cells by Siddharth Kaul, Vellareddy Anantharam, Yongjie Yang, Christopher J. Choi, Arthi Kanthasamy, Anumantha G. Kanthasamy

“…Oxidative stress is a key apoptotic stimulus in neuronal cell death and has been implicated in the pathogenesis of many neurodegenerative disorders, including…”
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Interaction of prion protein with divalent metals: Possible role in neuroprotection and neurodegeneration in prion disease model by Choi, Christopher J

“…Transmissible Spongiform Encephalopathy (TSE) is a set of diseases caused by a change in conformation of the cellular prion protein. This alteration in…”
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