Search Results - "Choi, Bu Young"

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss by Choi, Bu Young

“…Persistent hair loss is a major cause of psychological distress and compromised quality of life in millions of people worldwide. Remarkable progress has been…”
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Curcumin interacts directly with the Cysteine 259 residue of STAT3 and induces apoptosis in H-Ras transformed human mammary epithelial cells by Hahn, Young-Il, Kim, Su-Jung, Choi, Bu-Young, Cho, Kyung-Cho, Bandu, Raju, Kim, Kwang Pyo, Kim, Do-Hee, Kim, Wonki, Park, Joon Sung, Han, Byung Woo, Lee, Jeewoo, Na, Hye-Kyung, Cha, Young-Nam, Surh, Young-Joon

“…Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is latent but constitutively activated in many types of cancers. It…”
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(-)-Epigallocatechin Gallate Regulates CD3-mediated T Cell Receptor Signaling in Leukemia through the Inhibition of ZAP-70 Kinase by Shim, Jung-Hyun, Choi, Hong Seok, Pugliese, Angelo, Lee, Sung-Young, Chae, Jung-Il, Choi, Bu Young, Bode, Ann M., Dong, Zigang

“…The ζ chain-associated 70-kDa protein (ZAP-70) of tyrosine kinase plays a critical role in T cell receptor-mediated signal transduction and the immune…”
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Biochemical Basis of Anti-Cancer-Effects of Phloretin-A Natural Dihydrochalcone by Choi, Bu Young

“…Apple is a rich source of bioactive phytochemicals that help improve health by preventing and/or curing many disease processes, including cancer. One of the…”
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Resveratrol Suppresses Growth of Human Ovarian Cancer Cells in Culture and in a Murine Xenograft Model: Eukaryotic Elongation Factor 1A2 as a Potential Target by LEE, Mee-Hyun, BU YOUNG CHOI, JOYDEB KUMAR KUNDU, YOUNG KEE SHIN, NA, Hye-Kyung, SURH, Young-Joon

“…The eukaryotic elongation factor 1A2 (eEF1A2) is known to retain oncogenic potential and is recognized as a novel target for cancer prevention and therapy…”
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Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms by Choi, Bu Young

“…The functional aspect of scalp hair is not only to protect from solar radiation and heat/cold exposure but also to contribute to one's appearance and…”
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Molecular and chemical regulation of the Keap1-Nrf2 signaling pathway by Keum, Young-Sam, Choi, Bu Young

“…Extracellular and intracellular oxidants or electrophiles are key contributors to the damages in cellular macromolecules, such as DNA, proteins and lipids…”
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Costunolide-A Bioactive Sesquiterpene Lactone with Diverse Therapeutic Potential by Kim, Dae Yong, Choi, Bu Young

“…Sesquiterpene lactones constitute a major class of bioactive natural products. One of the naturally occurring sesquiterpene lactones is costunolide, which has…”
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Isocitrate dehydrogenase mutations: new opportunities for translational research by Keum, Young-Sam, Choi, Bu Young

“…Over the last decade, comprehensive genome-wide sequencing studies have enabled us to find out unexpected genetic alterations of metabolism in cancer. An…”
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Withaferin-A--A Natural Anticancer Agent with Pleitropic Mechanisms of Action by Lee, In-Chul, Choi, Bu Young

“…Cancer, being the second leading cause of mortality, exists as a formidable health challenge. In spite of our enormous efforts, the emerging complexities in…”
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Implications of Genetic and Epigenetic Alterations of CDKN2A (p16INK4a) in Cancer by Zhao, Ran, Choi, Bu Young, Lee, Mee-Hyun, Bode, Ann M., Dong, Zigang

“…Aberrant gene silencing is highly associated with altered cell cycle regulation during carcinogenesis. In particular, silencing of the CDKN2A tumor suppressor…”
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Acetylshikonin suppressed growth of colorectal tumour tissue and cells by inhibiting the intracellular kinase, T‐lymphokine‐activated killer cell‐originated protein kinase by Zhao, Ran, Choi, Bu Young, Wei, Lixiao, Fredimoses, Mangaladoss, Yin, Fanxiang, Fu, Xiaorong, Chen, Hanyong, Liu, Kangdong, Kundu, Joydeb Kumar, Dong, Zigang, Lee, Mee‐Hyun

“…Background and Purpose Overexpression or aberrant activation of the T‐lymphokine‐activated killer cell‐originated protein kinase (TOPK) promotes gene…”
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CR229, a novel derivative of β‐carbolin‐1‐one, induces cell cycle arrest and apoptosis in HeLa cells via p53 activation by Kim, Min Kyoung, Oh, Ha Lim, Choi, Bu‐Young, Lim, Haeyoung, Cho, Youl‐Hee, Lee, Chul‐Hoon

“…In the course of screening for novel anticancer compounds, CR229 (6‐Bromo‐2,3,4,9‐tetrahydro‐carbolin‐1‐one), a novel derivative of β‐carbolin‐1‐one, was…”
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Targeting TAOK1 with resveratrol inhibits esophageal squamous cell carcinoma growth in vitro and in vivo by Song, Mengqiu, Qu, Yingzi, Jia, Huajie, Zhang, Yunqing, Liu, Shihui, Laster, Kyle Vaughn, Choi, Bu Young, Tian, Jie, Gu, Tingxuan, Chen, Hanyong, Liu, Kangdong, Lee, Mee‐Hyun, Dong, Zigang

“…The worldwide incidence and mortality rates of esophageal squamous cell carcinoma (ESCC) have increased over the last decade. Moreover, molecular targets that…”
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Cell growth inhibition by 3-deoxysappanchalcone is mediated by directly targeting the TOPK signaling pathway in colon cancer by Zhao, Ran, Huang, Hai, Choi, Bu Young, Liu, Xuejiao, Zhang, Man, Zhou, Silei, Song, Mengqiu, Yin, Fanxiang, Chen, Hanyong, Shim, Jung-Hyun, Bode, Ann M., Dong, Zigang, Lee, Mee-Hyun

“…•TOPK is a direct target of 3-deoxysappanchalcone (3-DSC).•3-DSC inhibits cell growth of colon cancer cells.•3-DSC suppresses TOPK-mediated signaling pathways…”
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Dual Roles of Pin1 in Cancer Development and Progression by Han, Hyeong-Jun, Choi, Bu Young, Surh, Young-Joon

“…Pin1 is a unique peptidyl-prolyl cis/trans isomerase (PPIase) that catalyzes the cis/trans isomerization of peptidyl-prolyl peptide bonds of its substrate…”
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Acetylshikonin Inhibits Human Pancreatic PANC-1 Cancer Cell Proliferation by Suppressing the NF-κB Activity by Cho, Seok-Cheol, Choi, Bu Young

“…Acetylshikonin, a natural naphthoquinone derivative compound, has been used for treatment of inflammation and cancer. In the present study, we have…”
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An updated review on molecular mechanisms underlying the anticancer effects of capsaicin by Cho, Seok-Cheol, Lee, Hyosung, Choi, Bu Young

“…The quest for developing anticancer principles from natural sources has a long historical track record and remarkable success stories. The pungent principle of…”
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(-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78 by Ermakova, Svetlana P, Kang, Bong Seok, Choi, Bu Young, Choi, Hong Seok, Schuster, Todd F, Ma, Wei-Ya, Bode, Ann M, Dong, Zigang

“…Many beneficial properties have been attributed to (-)-epigallocatechin gallate (EGCG), including chemopreventive, anticarcinogenic, and antioxidant actions…”
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Sensitization of 5-Fluorouracil-Resistant SNUC5 Colon Cancer Cells to Apoptosis by α-Mangostin by Lee, June, Kang, Jong-Su, Choi, Bu-Young, Keum, Young-Sam

“…5-fluorouracil (5-FU) is a chemotherapeutic agent commonly used for treatment of solid tumors, including colorectal cancer. However, chemoresistance against…”
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