Search Results - "Choi, Beom K"

Siglec1-expressing subcapsular sinus macrophages provide soil for melanoma lymph node metastasis by Singh, Rohit, Choi, Beom K

“…Lymph nodes (LNs) are a common site of metastasis in solid cancers, and cutaneous melanomas show inherent properties of LN colonization. However, interactions…”
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4-1BB immunotherapy: advances and hurdles by Singh, Rohit, Kim, Young-Ho, Lee, Sang-Jin, Eom, Hyeon-Seok, Choi, Beom K.

“…Since its initial description 35 years ago as an inducible molecule expressed in cytotoxic and helper T cells, 4-1BB has emerged as a crucial receptor in…”
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The Murine CD137/CD137 Ligand Signalosome: A Signal Platform Generating Signal Complexity by Choi, Beom K, Lee, Hyeon-Woo

“…CD137, a member of the TNFR family, is a costimulatory receptor, and CD137L, a member of the TNF family, is its ligand. Studies using CD137- and…”
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TJP1 Contributes to Tumor Progression through Supporting Cell-Cell Aggregation and Communicating with Tumor Microenvironment in Leiomyosarcoma by Lee, Eun-Young, Kim, Minjeong, Choi, Beom K, Kim, Dae Hong, Choi, Inho, You, Hye Jin

“…Leiomyosarcoma (LMS) is a mesenchymal malignancy with a complex karyotype. Despite accumulated evidence, the factors contributing to the development of LMS are…”
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Midkine Is a Potential Therapeutic Target of Tumorigenesis, Angiogenesis, and Metastasis in Non-Small Cell Lung Cancer by Shin, Dong Hoon, Jo, Jeong Yeon, Kim, Sun Ha, Choi, Minyoung, Han, Chungyong, Choi, Beom K., Kim, Sang Soo

“…Hypoxia-inducible factors (HIFs) induced by reduced O2 availability activate the transcription of target genes encoding proteins that play important roles in…”
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Adoptive immunotherapy with transient anti-CD4 treatment enhances anti-tumor response by increasing IL-18Rαhi CD8+ T cells by Kim, Seon-Hee, Cho, Eunjung, Kim, Yu I., Han, Chungyong, Choi, Beom K., Kwon, Byoung S.

“…Adoptive T cell therapy (ACT) requires lymphodepletion preconditioning to eliminate immune-suppressive elements and enable efficient engraftment of adoptively…”
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Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression by Han, Chungyong, Sim, Su-Jung, Kim, Seon-Hee, Singh, Rohit, Hwang, Sunhee, Kim, Yu I., Park, Sang H., Kim, Kwang H., Lee, Don G., Oh, Ho S., Lee, Sangeun, Kim, Young H., Choi, Beom K., Kwon, Byoung S.

“…Chimeric antigen receptor (CAR) T cell therapy is an effective method for treating specific cancers. CARs are normally designed to recognize antigens, which…”
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Cross-Activation of Regulatory T Cells by Self Antigens Limits Self-Reactive and Activated CD8+ T Cell Responses by Cho, Eunjung, Han, Seongeun, Eom, Hyeon Seok, Lee, Sang-Jin, Han, Chungyong, Singh, Rohit, Kim, Seon-Hee, Park, Bo-Mi, Kim, Byoung-Gie, Kim, Young H, Kwon, Byoung S, Nam, Ki Taek, Choi, Beom K

“…The interaction between regulatory T (Treg) cells and self-reactive T cells is a crucial mechanism for maintaining immune tolerance. In this study, we…”
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Targeting Actomyosin Contractility Suppresses Malignant Phenotypes of Acute Myeloid Leukemia Cells by Chang, Fengjiao, Kong, So Jung, Wang, Lele, Choi, Beom K, Lee, Hyewon, Kim, Chan, Kim, Jin Man, Park, Kyungpyo

“…Actomyosin-mediated contractility is required for the majority of force-driven cellular events such as cell division, adhesion, and migration. Under…”
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Extracellular stimulation of VSIG4/complement receptor Ig suppresses intracellular bacterial infection by inducing autophagy by Kim, Kwang H., Choi, Beom K., Kim, Young H., Han, Chungyong, Oh, Ho S., Lee, Don G., Kwon, Byoung S.

“…VSIG4/CRIg (V-set and immunoglobulin domain containing 4) is a transmembrane receptor of the immunoglobulin superfamily that is expressed specifically on…”
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4-1BB Signaling Enhances Primary and Secondary Population Expansion of CD8+ T Cells by Maximizing Autocrine IL-2/IL-2 Receptor Signaling by Oh, Ho S, Choi, Beom K, Kim, Young H, Lee, Don G, Hwang, Sunhee, Lee, Myoung J, Park, Sang H, Bae, Yong-Soo, Kwon, Byoung S

“…4-1BB (CD137), a member of the tumor necrosis factor receptor superfamily (TNFRSF), is primarily expressed on activated T cells and is known to enhance…”
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Chimeric Antigen Receptor T Cells With Modified Interleukin-13 Preferentially Recognize IL13Rα2 and Suppress Malignant Glioma: A Preclinical Study by Kim, Kiwan, Gwak, Ho-Shin, Han, Nayoung, Hong, Eun Kyung, Choi, Beom K, Lee, Sangeun, Choi, Soyoung, Park, Ju-Hwang, Seok, Ji-Hye, Jeon, Yeongha, Cho, Hyuntae, Lee, Song-Jae, Lee, Yura, Nam, Ki Taek, Song, Seong-Won

“…Interleukin-13 receptor α 2 (IL13Rα2) is a promising tumor-directed antigen of malignant glioma (MG). Here, we examine the efficacy and safety of T cells…”
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4-1BB signaling activates the t cell factor 1 effector/β-catenin pathway with delayed kinetics via ERK signaling and delayed PI3K/AKT activation to promote the proliferation of CD8+ T Cells by Lee, Do Y, Choi, Beom K, Lee, Don G, Kim, Young H, Kim, Chang H, Lee, Seung J, Kwon, Byoung S

“…4-1BB (CD137), an inducible costimulatory molecule, strongly enhances the proliferation and effector function of CD8(+) T cells. Since the serine/threonine…”
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Pro- and Anti-Tumoral Factors Involved in Total Body Irradiation and Interleukin-2 Conditioning in Adoptive T Cell Therapy of Melanoma-Bearing Rag1 Knock-Out Mice by Kim, Seon-Hee, Go, Eun Mi, Shin, Dong Hoon, Choi, Beom K, Han, Chungyong

“…In adoptive T cell therapy (ACT), the transfer of tumor-specific T cells is paralleled by the conditioning regimen to increase therapeutic efficacy…”
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The repopulating cancer cells in melanoma are characterized by increased mitochondrial membrane potential by Lee, Don G, Choi, Beom K, Kim, Young H, Oh, Ho S, Park, Sang H, Bae, Young Soo, Kwon, Byoung S

“…Highlights • B16-F10 melanoma cells have mitochondrial heterogeneity under stress conditions. • B16-F10 melanoma cells with enhanced mitochondrial membrane…”
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TJP1 Contributes to Tumor Progression through Supporting Cell-Cell Aggregation and Communicating with Tumor Microenvironment in Leiomyosarcoma by Lee, Eun-Young, Kim, Minjeong, Choi, Beom K, Kim, Dae Hong, Choi, Inho, You, Hye Jin

“…Leiomyosarcoma (LMS) is a mesenchymal malignancy with a complex karyotype. Despite accumulated evidence, the factors contributing to the development of LMS are…”
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IL7-Fc Enhances the Efficacy of Adoptive T Cell Therapy under Lymphopenic Conditions in a Murine Melanoma Model by Yu, Eun M, Cho, Eunjung, Singh, Rohit, Kim, Seon-Hee, Han, Chungyong, Han, Seongeun, Lee, Don G, Kim, Young H, Kwon, Byoung S, Choi, Beom K

“…Adoptive cell therapy (ACT) using tumor-reactive T cells is a promising form of immunotherapy to specifically target cancer. However, the survival and…”
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4-1BB Functions As a Survival Factor in Dendritic Cells by Choi, Beom K, Kim, Young H, Kwon, Patrick M, Lee, Sang C, Kang, Sang W, Kim, Moon S, Lee, Myoung J, Kwon, Byoung S

“…4-1BB (CD137) is expressed on dendritic cells (DCs) and its biological function has remained largely unresolved. By comparing 4-1BB-intact (4-1BB(+/+)) and…”
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4-1BB-dependent inhibition of immunosuppression by activated CD4+CD25+ T cells by Choi, Beom K., Bae, Jun S., Choi, Eun M., Kang, Woo J., Sakaguchi, Shimon, Vinay, Dass S., Kwon, Byoung S.

“…4‐1BB (CD137) is a costimulatory molecule involved in the activation and survival of CD4, CD8, and natural killer cells. Although a great deal has been learned…”
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Mechanisms involved in synergistic anticancer effects of anti-4-1BB and cyclophosphamide therapy by Kim, Young H, Choi, Beom K, Oh, Ho S, Kang, Woo J, Mittler, Robert S, Kwon, Byoung S

“…Chemotherapy can precondition for immunotherapy by creating an environment for homeostatic lymphoproliferation and eliminating some of the suppressive immune…”
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