Effect of coenzyme Q10 on cutaneous healing in skin-incised mice

Coenzyme Q10 (CoQ10) is a biosynthesized quinone with 10 isoprene side chains in humans. To investigate the anti-inflammatory and wound healing effect of CoQ10, we performed in vivo and in vitro experiments. In vivo studies, there were 3 groups; Naive (without skin incision), Control (with skin inci...

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Bibliographic Details
Published in:	Archives of pharmacal research Vol. 32; no. 6; pp. 907 - 913
Main Authors:	Choi, Bang Shil, Song, Ho Sun, Kim, Hee Rae, Park, Tae Wook, Kim, Tae Doo, Cho, Bong Jae, Kim, Chang Jong, Sim, Sang Soo
Format:	Journal Article
Language:	English
Published:	Heidelberg Pharmaceutical Society of Korea 01-06-2009 대한약학회
Subjects:	Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Cell Line Male Malondialdehyde - metabolism Medicine Mice Mice, Inbred BALB C Peroxidase - metabolism Pharmacology/Toxicology Pharmacy Phospholipases A2 - metabolism Reactive Oxygen Species - antagonists & inhibitors Skin - injuries Skin - metabolism Superoxide Dismutase - metabolism Ubiquinone - analogs & derivatives Ubiquinone - pharmacology Ubiquinone - therapeutic use Wound Healing - drug effects 약학 Cutaneous healing Antioxidant Collagen-like polymer CoQ10
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Summary:	Coenzyme Q10 (CoQ10) is a biosynthesized quinone with 10 isoprene side chains in humans. To investigate the anti-inflammatory and wound healing effect of CoQ10, we performed in vivo and in vitro experiments. In vivo studies, there were 3 groups; Naive (without skin incision), Control (with skin incision) and CoQ10 (100 mg/kg treatment with skin incision). Collagen-like polymer (CLP) level of CoQ10 group was increased significantly compared to the control group ( p <0.05). Also, CoQ10 group showed significant inhibition on myeloperoxidase (MPO) and PLA 2 level compared to the control group ( p <0.05). These data show that CoQ10 may have an anti-inflammatory and a wound healing effect. CoQ10 showed significant antioxidant activity in vivo on malondialdehyde (MDA) and superoxide dismutase (SOD) levels compared to the control group ( p <0.05). Although CoQ10 did not show antioxidant activity in cell free system of DPPH radical scavenge, it had a potent antioxidant activity in cell culture system of both silica- and zymosan-induced reactive oxygen species generation using Raw 264.7 cells. This result may be associated with the conversion of CoQ10 to the reduced form (CoQ10H 2 ) in the presence of some kinds of intracellular reducing agents. In conclusion, it is considered that CoQ10 appears to have a cutaneous healing effect in vivo , which may be related to the secondary action of CoQ10.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 G704-000010.2009.32.6.012
ISSN:	0253-6269 1976-3786
DOI:	10.1007/s12272-009-1613-3