Search Results - "Chock, P. Boon"

Oxidative Modifications of RNA and Its Potential Roles in Biosystem by Tanaka, Mikiei, Chock, P. Boon

“…Elevated level of oxidized RNA was detected in vulnerable neurons in Alzheimer patients. Subsequently, several diseases and pathological conditions were…”
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Oxidized messenger RNA induces translation errors by Tanaka, Mikiei, Chock, P. Boon, Stadtman, Earl R

“…To investigate the effect of RNA oxidation on normal cellular functions, we studied the translation of nonoxidized and oxidized luciferase mRNA in both rabbit…”
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Deglutathionylation of 2-Cys Peroxiredoxin Is Specifically Catalyzed by Sulfiredoxin by Park, Ji Won, Mieyal, John J., Rhee, Sue Goo, Chock, P. Boon

“…Reversible protein glutathionylation plays a key role in cellular regulation and cell signaling and protects protein thiols from hyperoxidation. Sulfiredoxin…”
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Age-Dependent Cell Death and the Role of ATP in Hydrogen Peroxide-Induced Apoptosis and Necrosis by Miyoshi, Noriyuki, Oubrahim, Hammou, Chock, P. Boon, Stadtman, Earl R.

“…Cell death plays a pivotal role in the body to maintain homeostasis during aging. Studies have shown that damaged cells, which must be removed from the body,…”
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Structural Insights into the Catalytic Mechanism of Escherichia coli Selenophosphate Synthetase by Noinaj, Nicholas, Wattanasak, Rut, Lee, Duck-Yeon, Wally, Jeremy L, Piszczek, Grzegorz, Chock, P. Boon, Stadtman, Thressa C, Buchanan, Susan K

“…Selenophosphate synthetase (SPS) catalyzes the synthesis of selenophosphate, the selenium donor for the biosynthesis of selenocysteine and 2-selenouridine…”
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The Roles of Thioredoxin in Protection against Oxidative Stress-induced Apoptosis in SH-SY5Y Cells by Andoh, Tsugunobu, Chock, P. Boon, Chiueh, Chuang Chin

“…Using models of serum deprivation and 1-methyl-4-phenylpyridinium (MPP+), we investigated the mechanism by which thioredoxin (Trx) exerts its antiapoptotic…”
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RNA oxidation catalyzed by cytochrome c leads to its depurination and cross-linking, which may facilitate cytochrome c release from mitochondria by Tanaka, Mikiei, Jaruga, Pawel, Küpfer, Pascal A., Leumann, Christian J., Dizdaroglu, Miral, Sonntag, William E., Boon Chock, P.

“…Growing evidence indicates that RNA oxidation is correlated with a number of age-related neurodegenerative diseases, and RNA oxidation has also been shown to…”
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Expression of SUMO-2/3 Induced Senescence through p53- and pRB-mediated Pathways by Li, Tianwei, Santockyte, Rasa, Shen, Rong-Fong, Tekle, Ephrem, Wang, Guanghui, Yang, David C.H., Chock, P. Boon

“…Three highly homologous small ubiquitin-related modifier (SUMO) proteins have been identified in mammals. Modifications of proteins by SUMO-1 have been shown…”
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Knockout of caspase-like gene, YCA1, abrogates apoptosis and elevates oxidized proteins in Saccharomyces cerevisiae by Khan, M.A.S, Chock, P.B, Stadtman, E.R

“…In our previous study, we established that inhibition of apoptosis by the general caspase inhibitor is associated with an increase in the level of oxidized…”
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Sumoylation of Heterogeneous Nuclear Ribonucleoproteins, Zinc Finger Proteins, and Nuclear Pore Complex Proteins: A Proteomic Analysis by Li, Tianwei, Evdokimov, Evgenij, Shen, Rong-Fong, Chao, Chien-Chung, Tekle, Ephrem, Wang, Tao, Stadtman, Earl R., David C. H. Yang, Chock, P. Boon

“…SUMO, a small ubiquitin-related modifier, is known to covalently attach to a number of nuclear regulatory proteins such as p53, IκB, promyelocytic leukemia…”
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Stable and Controllable RNA Interference: Investigating the Physiological Function of Glutathionylated Actin by Wang, Jun, Tekle, Ephrem, Oubrahim, Hammou, Mieyal, John J., Stadtman, Earl R., Chock, P. Boon

“…RNA interference is an effective method to silence specific gene expression. Its application to mammalian cells, however, has been hampered by various…”
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Posttranslational modification of cysteine in redox signaling and oxidative stress: Focus on s-glutathionylation by Mieyal, John J, Chock, P Boon

“…Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have become recognized as second messengers for initiating and/or regulating vital cellular…”
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Implication of Phosphatidylinositol 3-Kinase Membrane Recruitment in Hydrogen Peroxide-Induced Activation of PI3K and Akt by Qin, Suofu, Chock, P. Boon

“…The effect of tyrosine phosphorylation of PI3K on its enzymatic activity is quite controversial, and the molecular mechanism by which ROS trigger PI3K membrane…”
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Induction of Thioredoxin and Mitochondrial Survival Proteins Mediates Preconditioning-Induced Cardioprotection and Neuroprotection by CHIUEH, CHUANG C., ANDOH, TSUGUNOBU, CHOCK, P BOON

“…: Delayed cardio‐ and neuroprotection are observed following a preconditioning procedure evoked by a brief and nontoxic oxidative stress due to deprivation of…”
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Manganese(II) Induces Apoptotic Cell Death in NIH3T3 Cells via a Caspase-12-dependent Pathway by Oubrahim, Hammou, Chock, P. Boon, Stadtman, Earl R.

“…Under physiological conditions, manganese(II) exhibits catalase-like activity. However, at elevated concentrations, it induces apoptosis via a…”
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SUMOylation of DLX3 by SUMO1 promotes its transcriptional activity by Duverger, Olivier, Chen, Susie X., Lee, Delia, Li, Tianwei, Chock, P. Boon, Morasso, Maria I.

“…Small ubiquitin‐like modifiers (SUMO) are post‐translational modifiers that regulate target protein activity in diverse ways. The most common group of SUMO…”
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Cyclic GMP-dependent Protein Kinase Regulates the Expression of Thioredoxin and Thioredoxin Peroxidase-1 during Hormesis in Response to Oxidative Stress-induced Apoptosis by Andoh, Tsugunobu, Chiueh, Chuang Chin, Chock, P. Boon

“…Human neuroblastoma cells, SH-SY5Y, contain relatively low levels of thioredoxin (Trx); thus, they serve favorably as a model for studying oxidative…”
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Mitochondria Play No Roles in Mn(II)-Induced Apoptosis in HeLa Cells by Oubrahim, Hammou, Stadtman, Earl R., Chock, P. Boon

“…Manganese(II) has been shown to exhibit catalase-like activity under physiological conditions. In the course of studies to test the antioxidant activity of…”
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Protein glutathionylation in the regulation of peroxiredoxins: a family of thiol-specific peroxidases that function as antioxidants, molecular chaperones, and signal modulators by Chae, Ho Zoon, Oubrahim, Hammou, Park, Ji Won, Rhee, Sue Goo, Chock, P Boon

“…Reversible protein glutathionylation plays an important role in cellular regulation, signaling transduction, and antioxidant defense. This redox-sensitive…”
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Glutathionylation of Peroxiredoxin I Induces Decamer to Dimers Dissociation with Concomitant Loss of Chaperone Activity by Park, Ji Won, Piszczek, Grzegorz, Rhee, Sue Goo, Chock, P. Boon

“…Reversible protein glutathionylation, a redox-sensitive regulatory mechanism, plays a key role in cellular regulation and cell signaling. Peroxiredoxins…”
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