Search Results - "Cho Young Man"

EpCAM and APN expression in combination with γ‐H2AX as biomarkers for detecting hepatocarcinogens in rats by Akagi, Jun‐ichi, Cho, Young‐Man, Toyoda, Takeshi, Mizuta, Yasuko, Ogawa, Kumiko

“…The phosphorylated form of histone H2AX (γ‐H2AX) serves as a commonly utilized biomarker for DNA damage. Based on our previous findings, which demonstrated the…”
Get full text

Size-dependent acute toxicity of silver nanoparticles in mice by Cho, Young-Man, Mizuta, Yasuko, Akagi, Jun-ichi, Toyoda, Takeshi, Sone, Mizuki, Ogawa, Kumiko

“…In this study, we aimed to evaluate changes in the acute toxicity of intraperitoneally administered silver nanoparticles (AgNPs) of varying sizes in BALB/c…”
Get full text

Histopathological and immunohistochemical evaluation for detecting changes in blood hormone levels caused by endocrine disruptors in a 28‐day repeated‐dose study in rats by Akane, Hirotoshi, Toyoda, Takeshi, Mizuta, Yasuko, Cho, Young‐Man, Ide, Tetsuya, Kosaka, Tadashi, Tajima, Hitoshi, Aoyama, Hiroaki, Ogawa, Kumiko

“…Although measurements of blood hormone levels in rodent toxicological studies can provide important information on the mechanisms of toxicity and extrapolation…”
Get full text

Anti-Inflammatory Effects of Capsaicin and Piperine on Helicobacter pylori-Induced Chronic Gastritis in Mongolian Gerbils by Toyoda, Takeshi, Shi, Liang, Takasu, Shinji, Cho, Young-Man, Kiriyama, Yuka, Nishikawa, Akiyoshi, Ogawa, Kumiko, Tatematsu, Masae, Tsukamoto, Tetsuya

“…Background Spices have been used for thousands of years, and recent studies suggest that certain spices confer beneficial effects on gastric disorders. The…”
Get full text

Immunohistochemistry of γ‐H2AX as a method of early detection of urinary bladder carcinogenicity in mice by Sone, Mizuki, Toyoda, Takeshi, Cho, Young‐Man, Akagi, Jun‐ichi, Matsushita, Kohei, Mizuta, Yasuko, Morikawa, Tomomi, Nishikawa, Akiyoshi, Ogawa, Kumiko

“…Phosphorylated histone H2AX (γ‐H2AX) has been demonstrated as a DNA damage marker both in vitro and in vivo. We previously reported the effects of genotoxic…”
Get full text

Early detection of hepatocarcinogens in rats by immunohistochemistry of γ-H2AX by Toyoda, Takeshi, Sone, Mizuki, Matsushita, Kohei, Akane, Hirotoshi, Akagi, Jun-ichi, Morikawa, Tomomi, Mizuta, Yasuko, Cho, Young-Man, Ogawa, Kumiko

“…We have developed an early detection method for bladder carcinogens with high sensitivity and specificity using immunohistochemistry of γ-H2AX, a well-known…”
Get full text

4-Methylthio-3-butenyl isothiocyanate (MTBITC) induced apoptotic cell death and G2/M cell cycle arrest via ROS production in human esophageal epithelial cancer cells by Hirata, Tadashi, Cho, Young-Man, Suzuki, Isamu, Toyoda, Takeshi, Akagi, Jun-ichi, Nakamura, Yasushi, Numazawa, Satoshi, Ogawa, Kumiko

“…To investigate the chemopreventive mechanisms of 4-Methylthio-3-butenyl isothiocyanate (MTBITC), we analyzed cell viability, cell cycle distribution, and…”
Get full text

Spontaneous adenolipoma of the mammary gland in the male F344 rat by Ide, Tetsuya, Cho, Young-Man, Oishi, Yuji, Ogawa, Kumiko

“…A 110-week-old male F344 rat from the high-dose group of a 104-week carcinogenicity study, exhibited a spontaneously occurring subcutaneous mass in the left…”
Get full text

Validation study of the combined repeated‐dose toxicity and genotoxicity assay using gpt delta rats by Akagi, Jun‐ichi, Toyoda, Takeshi, Cho, Young‐Man, Mizuta, Yasuko, Nohmi, Takehiko, Nishikawa, Akiyoshi, Ogawa, Kumiko

“…Transgenic rodents carrying reporter genes to detect organ‐specific in vivo genetic alterations are useful for risk assessment of genotoxicity that causes…”
Get full text

Subchronic toxicity evaluation of 5-hexenyl isothiocyanate, a nature identical flavoring substance from Wasabia japonica, in F344/DuCrj rats by Akagi, Jun-ichi, Cho, Young-Man, Mizuta, Yasuko, Toyoda, Takeshi, Ogawa, Kumiko

“…5-Hexenyl isothiocyanate (5-HeITC) is a naturally derived flavoring substance from Wasabia japonica. To clarify the toxicological profile of 5-HeITC, we…”
Get full text

Expression of stem cell markers as useful complementary factors in the early detection of urinary bladder carcinogens by immunohistochemistry for γ-H2AX by Yamada, Takanori, Toyoda, Takeshi, Matsushita, Kohei, Cho, Young-Man, Akagi, Jun-ichi, Morikawa, Tomomi, Mizuta, Yasuko, Ogawa, Kumiko

“…We previously demonstrated that immunohistochemistry for γ-H2AX, a biomarker of DNA damage, is useful for early detection of urinary bladder carcinogens in…”
Get full text

A 13-week subchronic toxicity study of acetaminophen using an obese rat model by Toyoda, Takeshi, Cho, Young-Man, Akagi, Jun-ichi, Mizuta, Yasuko, Matsushita, Kohei, Nishikawa, Akiyoshi, Imaida, Katsumi, Ogawa, Kumiko

“…Although obesity is increasing worldwide, experimental studies examining the possible association between obesity and susceptibility to chemical toxicity are…”
Get full text

A 13-week repeated dose study of three 3-monochloropropane-1,2-diol fatty acid esters in F344 rats by Onami, Saeko, Cho, Young-man, Toyoda, Takeshi, Mizuta, Yasuko, Yoshida, Midori, Nishikawa, Akiyoshi, Ogawa, Kumiko

“…3-monochloropropane-1,2-diol (3-MCPD), a rat renal and testicular carcinogen, has been reported to occur in various foods and food ingredients as free or…”
Get full text

Subchronic toxicity evaluation of isoeugenyl methyl ether in F344/DuCrj rats by 13-week oral administration by Akagi, Jun-ichi, Cho, Young-Man, Mizuta, Yasuko, Tatebe, Chiye, Sato, Kyoko, Ogawa, Kumiko

“…Isoeugenyl methyl ether (CAS No. 93-16-3) is a food additive used as a nature identical flavoring agent. To determine the toxicity profile and the…”
Get full text

A 13-week subchronic toxicity study of hexyl acetate in SD rats by Toyoda, Takeshi, Cho, Young-Man, Matsushita, Kohei, Tachibana, Shigehiro, Senuma, Mika, Akagi, Jun-ichi, Ogawa, Kumiko

“…Hexyl acetate (CAS No. 142-92-7) is a naturally occurring ester compound that has a fruity odor. Despite its frequent use as a nature-identical flavoring…”
Get full text

Horseradish extract promotes urinary bladder carcinogenesis when administered to F344 rats in drinking water by Cho, Young‐Man, Hasumura, Mai, Imai, Toshio, Takami, Shigeaki, Nishikawa, Akiyoshi, Ogawa, Kumiko

“…Horseradish extract (HRE), consisting mainly of a mixture of allyl isothiocyanate and other isothiocyanates, has been used as a food additive. To evaluate the…”
Get full text

A 90-day repeated oral dose toxicity study of four stereoisomers of 2,4-dimethyl-4-phenyltetrahydrofuran, a synthetic flavoring substance, in F344 rats by Ide, Tetsuya, Mizuta, Yasuko, Akagi, Jun-ichi, Masumoto, Naoko, Sugimoto, Naoki, Sato, Kyoko, Ogawa, Kumiko, Cho, Young-Man

“…2,4-Dimethyl-4-phenyltetrahydrofuran (CAS no. 82461-14-1) is a food additive used as a synthetic flavoring substance. To investigate the toxicological…”
Get full text

Twist1 was detected in mesenchymal cells of mammary fibroadenoma and invasive components of breast carcinoma in rats by Funahashi, Satomi, Okazaki, Yasumasa, Nagai, Hirotaka, Chew, Shan Hwu, Ogawa, Kumiko, Toyoda, Takeshi, Cho, Young-Man, Toyokuni, Shinya

“…Fibroadenoma (FA) is a common mammary fibroepithelial tumor. The tumor size of the FA is increased by estrogen, progesterone, prolactin, and pregnancy, whereas…”
Get full text

Orally administered glycidol and its fatty acid esters as well as 3-MCPD fatty acid esters are metabolized to 3-MCPD in the F344 rat by Onami, Saeko, Cho, Young-Man, Toyoda, Takeshi, Akagi, Jun-ichi, Fujiwara, Satoshi, Ochiai, Ryosuke, Tsujino, Kazushige, Nishikawa, Akiyoshi, Ogawa, Kumiko

“…IARC has classified glycidol and 3-monochloropropane-1,2-diol (3-MCPD) as group 2A and 2B, respectively. Their esters are generated in foodstuffs during…”
Get full text

Lack of in vivo mutagenicity of 1,2‐dichloropropane and dichloromethane in the livers of gpt delta rats administered singly or in combination by Hirata, Tadashi, Cho, Young‐Man, Toyoda, Takeshi, Akagi, Jun‐ichi, Suzuki, Isamu, Nishikawa, Akiyoshi, Ogawa, Kumiko

“…1,2‐Dichloropropane (1,2‐DCP) and dichloromethane (DCM) are possible causative agents associated with the development of cholangiocarcinoma in employees…”
Get full text