Search Results - "Cho, Sungchan"

A degron created by SMN2 exon 7 skipping is a principal contributor to spinal muscular atrophy severity by Cho, Sungchan, Dreyfuss, Gideon

“…Spinal muscular atrophy (SMA) is caused by homozygous survival of motor neurons 1 (SMN1) gene deletions, leaving a duplicate gene, SMN2, as the sole source of…”
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Development of a miRNA-controlled dual-sensing system and its application for targeting miR-21 signaling in tumorigenesis by Seo, Yoona, Kim, Sung Soo, Kim, Namdoo, Cho, Sungchan, Park, Jong Bae, Kim, Jong Heon

“…MicroRNAs (miRNAs) are considered to be strong prognostic markers and key therapeutic targets in human diseases, especially cancer. A sensitive monitoring…”
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β-Arrestin 2 Mediates G Protein-Coupled Receptor 43 Signals to Nuclear Factor-κB by Lee, Su Ui, In, Hyun Ju, Kwon, Mi So, Park, Bi-oh, Jo, Minmi, Kim, Mun-Ock, Cho, Sungchan, Lee, Sangku, Lee, Hyun-Jun, Kwak, Young Shin, Kim, Sunhong

“…G-protein coupled receptor 43 (GPR43) serves as a receptor for short-chain fatty acids (SCFAs), implicated in neutrophil migration and inflammatory cytokine…”
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Identification of a novel function of CX-4945 as a splicing regulator by Kim, Hyeongki, Choi, Kwangman, Kang, Hyunju, Lee, So-Young, Chi, Seung-Wook, Lee, Min-Sung, Song, Jaehyoung, Im, Donghwa, Choi, Yura, Cho, Sungchan

“…Alternative splicing is a nearly ubiquitous versatile process that controls gene expression and creates numerous protein isoforms with different functions from…”
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A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition by Kim, Hyeongki, Lee, Kyu-Sun, Kim, Ae-Kyeong, Choi, Miri, Choi, Kwangman, Kang, Mingu, Chi, Seung-Wook, Lee, Min-Sung, Lee, Jeong-Soo, Lee, So-Young, Song, Woo-Joo, Yu, Kweon, Cho, Sungchan

“…DYRK1A is important in neuronal development and function, and its excessive activity is considered a significant pathogenic factor in Down syndrome and…”
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A novel de novo heterozygous DYRK1A mutation causes complete loss of DYRK1A function and developmental delay by Lee, Kyu-Sun, Choi, Miri, Kwon, Dae-Woo, Kim, Doyoun, Choi, Jong-Moon, Kim, Ae-Kyeong, Ham, Youngwook, Han, Sang-Bae, Cho, Sungchan, Cheon, Chong Kun

“…Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is essential for human development, and DYRK1A haploinsufficiency is associated with a…”
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Identification and Validation of a Selective Small Molecule Inhibitor Targeting the Diacylglycerol Acyltransferase 2 Activity by Kim, Mun Ock, Lee, Su Ui, Lee, Hyun-Jun, Choi, Kwangman, Kim, Hyeongki, Lee, Sangku, Oh, Soo Jin, Kim, Sunhong, Kang, Jong Soon, Lee, Hyun Sun, Kwak, Young-Shin, Cho, Sungchan

“…Diacylglycerol acyltransferase 2 (DGAT2) is one of two distinct DGAT enzymes that catalyze the last step in triacylglycerol (TG) synthesis. Findings from…”
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Synergistic antiviral activity of gemcitabine and ribavirin against enteroviruses by Kang, Hyunju, Kim, Chonsaeng, Kim, Dong-eun, Song, Jae-Hyoung, Choi, Miri, Choi, Kwangman, Kang, Mingu, Lee, Kyungjin, Kim, Hae Soo, Shin, Jin Soo, Kim, Janghwan, Han, Sang-Bae, Lee, Mi-Young, Lee, Su Ui, Lee, Chong-Kyo, Kim, Meehyein, Ko, Hyun-Jeong, van Kuppeveld, Frank J.M., Cho, Sungchan

“…Enteroviruses are major causative agents of various human diseases, and some of them are currently considered to be an enormous threat to public health…”
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Inactivation of the SMN Complex by Oxidative Stress by Wan, Lili, Ottinger, Elizabeth, Cho, Sungchan, Dreyfuss, Gideon

“…The SMN complex is essential for the biogenesis of small nuclear ribonucleoproteins (snRNPs), the major constituents of the spliceosome. Deficiency in…”
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Antiviral Mechanisms of Saucerneol from Saururus chinensis against Enterovirus A71, Coxsackievirus A16, and Coxsackievirus B3: Role of Mitochondrial ROS and the STING/TKB-1/IRF3 Pathway by Song, Jae-Hyoung, Mun, Seo-Hyeon, Yang, Heejung, Kwon, Yong Soo, Kim, Seong-Ryeol, Song, Min-Young, Ham, Youngwook, Choi, Hwa-Jung, Baek, Won-Jin, Cho, Sungchan, Ko, Hyun-Jeong

“…Enterovirus A71 (EV71), coxsackievirus A16 (CVA16), and coxsackievirus B3 (CVB3) are pathogenic members of the family that cause a range of diseases, including…”
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Facile analysis of protein-protein interactions in living cells by enriched visualization of the p-body by Choi, Miri, Baek, Jiyeon, Han, Sang-Bae, Cho, Sungchan

“…Protein-Protein Interactions (PPIs) play essential roles in diverse biological processes and their misregulations are associated with a wide range of diseases…”
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Introducing property tax in China as an alternative financing source by Cho, SungChan, Choi, Philip PilSoo

“…•China has been involved in active discussion on the introduction of the property tax.•Yet the current land management system is unsustainable mainly because…”
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Antiviral and anti-inflammatory activity of budesonide against human rhinovirus infection mediated via autophagy activation by Kim, Seong-Ryeol, Song, Jae-Hyoung, Ahn, Jae-Hee, Lee, Geun-Shik, Ahn, Huijeong, Yoon, Sung-il, Kang, Seung Goo, Kim, Pyeung-Hyeun, Jeon, Sang-Min, Choi, Eun-Ji, Shin, Sooyoung, Cha, Younggil, Cho, Sungchan, Kim, Dong-eun, Chang, Sun-Young, Ko, Hyun-Jeong

“…Human rhinovirus (HRV) infection causes more than 80% of all common colds and is associated with severe complications in patients with asthma and chronic…”
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Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice by Kwon, Bo-Eun, Song, Jae-Hyoung, Song, Hyuk-Hwan, Kang, Ju Won, Hwang, Sam Noh, Rhee, Ki-Jong, Shim, Aeri, Hong, Eun-Hye, Kim, Yeon-Jeong, Jeon, Sang-Min, Chang, Sun-Young, Kim, Dong-Eun, Cho, Sungchan, Ko, Hyun-Jeong

“…The flavonoids mosloflavone, oroxylin A, and norwogonin, which were purified from Scutellaria baicalensis Georgi, significantly protected Vero cells against…”
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Regulation of Survival Motor Neuron Gene Expression by Calcium Signaling by Choi, Kwangman, Yang, Ansook, Baek, Jiyeon, Jeong, Hyejeong, Kang, Yura, Baek, Woosun, Kim, Joon-Chul, Kang, Mingu, Choi, Miri, Ham, Youngwook, Son, Min-Jeong, Han, Sang-Bae, Kim, Janghwan, Jang, Jae-Hyuk, Ahn, Jong Seog, Shen, Haihong, Woo, Sun-Hee, Kim, Jong Heon, Cho, Sungchan

“…Spinal muscular atrophy (SMA) is caused by homozygous survival of motor neurons 1 (SMN1) gene deletion, leaving a duplicate gene, SMN2, as the sole source of…”
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Inactivation of human DGAT2 by oxidative stress on cysteine residues by Jung, Sunhee, Choi, Miri, Choi, Kwangman, Kwon, Eun Bin, Kang, Mingu, Kim, Dong-Eun, Jeong, Hyejeong, Kim, Janghwan, Kim, Jong Heon, Kim, Mun Ock, Han, Sang-Bae, Cho, Sungchan

“…Diacylglycerol acyltransferases (DGATs) have a crucial role in the biosynthesis of triacylglycerol (TG), the major storage form of metabolic energy in…”
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hnRNP M facilitates exon 7 inclusion of SMN2 pre-mRNA in spinal muscular atrophy by targeting an enhancer on exon 7 by Cho, Sunghee, Moon, Heegyum, Loh, Tiing Jen, Oh, Huyn Kyung, Cho, Sungchan, Choy, Hyon E., Song, Woo Keun, Chun, Jang-Soo, Zheng, Xuexiu, Shen, Haihong

“…Spinal muscular atrophy (SMA) is an autosomal recessive genetic disease, which causes death of motor neurons in the anterior horn of the spinal cord. Genetic…”
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The ubiquitin ligase human TRIM71 regulates let-7 microRNA biogenesis via modulation of Lin28B protein by Lee, Seo Hyun, Cho, Sungchan, Kim, M. Sun, Choi, Kwangman, Cho, Jae Youl, Gwak, Ho-Shin, Kim, Youn-Jae, Yoo, Heon, Lee, Seung-Hoon, Park, Jong Bae, Kim, Jong Heon

“…let-7 microRNA (miRNA) is implicated in various biological processes, and its downregulation essentially linked to human malignancy. Regulation of gene…”
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Antiviral activity of micafungin against enterovirus 71 by Kim, Chonsaeng, Kang, Hyunju, Kim, Dong-Eun, Song, Jae-Hyoung, Choi, Miri, Kang, Mingu, Lee, Kyungjin, Kim, Hae Soo, Shin, Jin Soo, Jeong, Hyejeong, Jung, Sunhee, Han, Sang-Bae, Kim, Jong Heon, Ko, Hyun-Jeong, Lee, Chong-Kyo, Kim, Meehyein, Cho, Sungchan

“…Enterovirus 71 (EV71) is a major causative agent of hand-foot-mouth disease (HFMD) and also causes severe neurological complications, leading to fatality in…”
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Anti-Obesity Effects of Spiramycin In Vitro and In Vivo by Kim, Mun Ock, Ryu, Hyung Won, Choi, Ji-Hee, Son, Tae Hyun, Oh, Sei-Ryang, Lee, Hyun-Sun, Yuk, Heung Joo, Cho, Sungchan, Kang, Jong Soon, Lee, Chang Woo, Lee, Jinhyuk, Lee, Chong-Kil, Hong, Sung-Tae, Lee, Su Ui

“…The effects of spiramycin on adipogenesis and high fat diet (HFD)-induced obesity were investigated. Potential mechanisms contributing to these effects were…”
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