Search Results - "Cho, Naoki"

Formation of reactive metabolites of benzbromarone in humanized-liver mice by Cho, Naoki, Suemizu, Hiroshi, Kamimura, Hidetaka, Ohe, Tomoyuki, Ito, Fumi, Akita, Hidetaka, Kobayashi, Kaoru

“…Benzbromarone, a uricosuric drug, has the potential to cause serious hepatotoxicity. Several studies have shown the formation of reactive metabolites of…”
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Identification of novel glutathione adducts of benzbromarone in human liver microsomes by Cho, Naoki, Kobayashi, Kaoru, Yoshida, Mina, Kogure, Noriyuki, Takayama, Hiromitsu, Chiba, Kan

“…Benzbromarone (BBR) is a potent uricosuric drug that can cause serious liver injury. Our recent study suggested that 1′-hydroxy BBR, one of major metabolites…”
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Safety, Tolerability, and Pharmacokinetics of a Novel Oral Phosphodiesterase 4 Inhibitor, ME3183: First‐in‐Human Phase 1 Study by Kato, Seiji, Cho, Naoki, Koresawa, Tomokazu, Otake, Kazunari, Kano, Akiko

“…A novel, oral phosphodiesterase 4 (PDE4) inhibitor, ME3183, is under development for the treatment of psoriasis, atopic dermatitis, and other inflammatory…”
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ME3183, a novel phosphodiesterase-4 inhibitor, exhibits potent anti-inflammatory effects and is well tolerated in a non-clinical study by Kubota-Ishida, Natsuki, Kaji, Chizuko, Matsumoto, Shogo, Wakabayashi, Tsubasa, Matsuhira, Takashi, Okura, Iori, Cho, Naoki, Isshiki, Satoshi, Kumura, Ko, Tabata, Yuji

“…Phosphodiesterase 4 (PDE4) inhibitors are expected to exhibit efficacy against inflammatory diseases due to their broad pharmacological activity. The launched…”
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Empirical and theoretical approaches for the prediction of human hepatic clearance using chimeric mice with humanised liver: the use of physiologically based scaling, a novel solution for potential overprediction due to coexisting mouse metabolism by Matsumoto, Shogo, Kamimura, Hidetaka, Nishiwaki, Megumi, Cho, Naoki, Kato, Kazuhiko, Yamamoto, Taichi

“…Chimeric mice are immunodeficient mice in which the majority of the hepatic parenchymal cells are replaced with human hepatocytes. Following intravenous…”
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Selection of the candidate compound at an early stage of new drug development: retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets by Matsumoto, Shogo, Uehara, Shotaro, Kamimura, Hidetaka, Cho, Naoki, Ikeda, Hiroshi, Maeda, Satoshi, Kagiyama, Kensuke, Miyata, Atsunori, Suemizu, Hiroshi, Fukasawa, Kazumasa

“…Valsartan is an antihypertensive drug that was developed using common marmosets (Callithrix jacchus) in pivotal toxicity studies as a non-rodent species. The…”
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Association of a reactive intermediate derived from 1′,6‐dihydroxy metabolite with benzbromarone‐induced hepatotoxicity by Yoshida, Mina, Cho, Naoki, Akita, Hidetaka, Kobayashi, Kaoru

“…Treatment with benzbromarone can be associated with liver injury, but the detailed mechanism remains unknown. Our recent studies demonstrated that…”
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