Search Results - "Cho, Michael H"

PRIMUS: Rapid Reconstruction of Pedigrees from Genome-wide Estimates of Identity by Descent by Staples, Jeffrey, Qiao, Dandi, Cho, Michael H., Silverman, Edwin K., Nickerson, Deborah A., Below, Jennifer E.

“…Understanding and correctly utilizing relatedness among samples is essential for genetic analysis; however, managing sample records and pedigrees can often be…”
Get full text

Association Between Interstitial Lung Abnormalities and All-Cause Mortality by Putman, Rachel K, Hatabu, Hiroto, Araki, Tetsuro, Gudmundsson, Gunnar, Gao, Wei, Nishino, Mizuki, Okajima, Yuka, Dupuis, Josée, Latourelle, Jeanne C, Cho, Michael H, El-Chemaly, Souheil, Coxson, Harvey O, Celli, Bartolome R, Fernandez, Isis E, Zazueta, Oscar E, Ross, James C, Harmouche, Rola, Estépar, Raúl San José, Diaz, Alejandro A, Sigurdsson, Sigurdur, Gudmundsson, Elías F, Eiríksdottír, Gudny, Aspelund, Thor, Budoff, Matthew J, Kinney, Gregory L, Hokanson, John E, Williams, Michelle C, Murchison, John T, MacNee, William, Hoffmann, Udo, O’Donnell, Christopher J, Launer, Lenore J, Harrris, Tamara B, Gudnason, Vilmundur, Silverman, Edwin K, O’Connor, George T, Washko, George R, Rosas, Ivan O, Hunninghake, Gary M

“…IMPORTANCE: Interstitial lung abnormalities have been associated with lower 6-minute walk distance, diffusion capacity for carbon monoxide, and total lung…”
Get full text

Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma by McGeachie, Michael J, Yates, Katherine P, Zhou, Xiaobo, Guo, Feng, Sternberg, Alice L, Van Natta, Mark L, Wise, Robert A, Szefler, Stanley J, Sharma, Sunita, Kho, Alvin T, Cho, Michael H, Croteau-Chonka, Damien C, Castaldi, Peter J, Jain, Gaurav, Sanyal, Amartya, Zhan, Ye, Lajoie, Bryan R, Dekker, Job, Stamatoyannopoulos, John, Covar, Ronina A, Zeiger, Robert S, Adkinson, N. Franklin, Williams, Paul V, Kelly, H. William, Grasemann, Hartmut, Vonk, Judith M, Koppelman, Gerard H, Postma, Dirkje S, Raby, Benjamin A, Houston, Isaac, Lu, Quan, Fuhlbrigge, Anne L, Tantisira, Kelan G, Silverman, Edwin K, Tonascia, James, Weiss, Scott T, Strunk, Robert C

“…Data from a controlled trial of asthma treatment that enrolled patients in the first decade of life were combined with follow-up data to provide novel…”
Get full text

A statistical framework to identify cell types whose genetically regulated proportions are associated with complex diseases by Liu, Wei, Deng, Wenxuan, Chen, Ming, Dong, Zihan, Zhu, Biqing, Yu, Zhaolong, Tang, Daiwei, Sauler, Maor, Lin, Chen, Wain, Louise V, Cho, Michael H, Kaminski, Naftali, Zhao, Hongyu

“…Finding disease-relevant tissues and cell types can facilitate the identification and investigation of functional genes and variants. In particular, cell type…”
Get full text

Smoking duration alone provides stronger risk estimates of chronic obstructive pulmonary disease than pack-years by Bhatt, Surya P, Kim, Young-Il, Harrington, Kathy F, Hokanson, John E, Lutz, Sharon M, Cho, Michael H, DeMeo, Dawn L, Wells, James M, Make, Barry J, Rennard, Stephen I, Washko, George R, Foreman, Marilyn G, Tashkin, Donald P, Wise, Robert A, Dransfield, Mark T, Bailey, William C

“…Cigarette smoking is the strongest risk factor for COPD. Smoking burden is frequently measured in pack-years, but the relative contribution of cigarettes…”
Get more information

What do polymorphisms tell us about the mechanisms of COPD? by Li, Yan, Cho, Michael H, Zhou, Xiaobo

“…COPD (chronic obstructive pulmonary disease) is characterized by irreversible lung airflow obstruction. Cigarette smoke is the major risk factor for COPD…”
Get more information

Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene by Ragland, Margaret F, Benway, Christopher J, Lutz, Sharon M, Bowler, Russell P, Hecker, Julian, Hokanson, John E, Crapo, James D, Castaldi, Peter J, DeMeo, Dawn L, Hersh, Craig P, Hobbs, Brian D, Lange, Christoph, Beaty, Terri H, Cho, Michael H, Silverman, Edwin K

“…Chronic obstructive pulmonary disease (COPD) is a common and progressive disease that is influenced by both genetic and environmental factors. For many years,…”
Get full text

Bilirubin-associated single nucleotide polymorphism (SNP) and respiratory health outcomes: a mendelian randomization study by Baldomero, Arianne K, MacDonald, David M, Kaplan, Adam, Lock, Eric, Cho, Michael H, Bowler, Russell, Gillenwater, Lucas, Kunisaki, Ken M, Wendt, Chris H

“…Observational studies have shown an association between higher bilirubin levels and improved respiratory health outcomes. Targeting higher bilirubin levels has…”
Get full text

Identification of putative causal loci in whole-genome sequencing data via knockoff statistics by He, Zihuai, Liu, Linxi, Wang, Chen, Le Guen, Yann, Lee, Justin, Gogarten, Stephanie, Lu, Fred, Montgomery, Stephen, Tang, Hua, Silverman, Edwin K., Cho, Michael H., Greicius, Michael, Ionita-Laza, Iuliana

“…The analysis of whole-genome sequencing studies is challenging due to the large number of rare variants in noncoding regions and the lack of natural units for…”
Get full text

Genetic overlap of chronic obstructive pulmonary disease and cardiovascular disease-related traits: a large-scale genome-wide cross-trait analysis by Zhu, Zhaozhong, Wang, Xiaofang, Li, Xihao, Lin, Yifei, Shen, Sipeng, Liu, Cong-Lin, Hobbs, Brain D, Hasegawa, Kohei, Liang, Liming, Boezen, H Marike, Camargo, Jr, Carlos A, Cho, Michael H, Christiani, David C

“…A growing number of studies clearly demonstrate a substantial association between chronic obstructive pulmonary disease (COPD) and cardiovascular diseases…”
Get full text

A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes by Cho, Michael H, Castaldi, Peter J, Hersh, Craig P, Hobbs, Brian D, Barr, R Graham, Tal-Singer, Ruth, Bakke, Per, Gulsvik, Amund, San José Estépar, Raúl, Van Beek, Edwin J R, Coxson, Harvey O, Lynch, David A, Washko, George R, Laird, Nan M, Crapo, James D, Beaty, Terri H, Silverman, Edwin K

“…Chronic obstructive pulmonary disease (COPD) is defined by the presence of airflow limitation on spirometry, yet subjects with COPD can have marked differences…”
Get full text

Prediction and stratification of longitudinal risk for chronic obstructive pulmonary disease across smoking behaviors by He, Yixuan, Qian, David C., Diao, James A., Cho, Michael H., Silverman, Edwin K., Gusev, Alexander, Manrai, Arjun K., Martin, Alicia R., Patel, Chirag J.

“…Smoking is the leading risk factor for chronic obstructive pulmonary disease (COPD) worldwide, yet many people who never smoke develop COPD. We perform a…”
Get full text

Fast computation of the eigensystem of genomic similarity matrices by Hahn, Georg, Lutz, Sharon M, Hecker, Julian, Prokopenko, Dmitry, Cho, Michael H, Silverman, Edwin K, Weiss, Scott T, Lange, Christoph

“…The computation of a similarity measure for genomic data is a standard tool in computational genetics. The principal components of such matrices are routinely…”
Get full text

Heritability of Chronic Obstructive Pulmonary Disease and Related Phenotypes in Smokers by ZHOU, Jin J, CHO, Michael H, CASTALDI, Peter J, HERSH, Craig P, SILVERMAN, Edwin K, LAIRD, Nan M

“…Previous studies of chronic obstructive pulmonary disease (COPD) have suggested that genetic factors play an important role in the development of disease…”
Get full text

Hierarchical association of COPD to principal genetic components of biological systems by Carlin, Daniel E, Larsen, Simon J, Sirupurapu, Vikram, Cho, Michael H, Silverman, Edwin K, Baumbach, Jan, Ideker, Trey

“…Many disease-causing genetic variants converge on common biological functions and pathways. Precisely how to incorporate pathway knowledge in genetic…”
Get full text

Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study by Hayden, Lystra P, Cho, Michael H, Raby, Benjamin A, Beaty, Terri H, Silverman, Edwin K, Hersh, Craig P

“…Childhood asthma is strongly influenced by genetics and is a risk factor for reduced lung function and chronic obstructive pulmonary disease (COPD) in adults…”
Get full text

Silent Airway Mucus Plugs in COPD and Clinical Implications by Mettler, Sofia K., Nath, Hrudaya P., Grumley, Scott, Orejas, José L., Dolliver, Wojciech R., Nardelli, Pietro, Yen, Andrew C., Kligerman, Seth J., Jacobs, Kathleen, Manapragada, Padma P., Abozeed, Mostafa, Aziz, Muhammad Usman, Zahid, Mohd, Ahmed, Asmaa N., Terry, Nina L., Elalami, Rim, Estépar, Ruben San José, Sonavane, Sushilkumar, Billatos, Ehab, Wang, Wei, Estépar, Raúl San José, Richards, Jeremy B., Cho, Michael H., Diaz, Alejandro A.

“…Airway mucus plugs are frequently identified on CT scans of patients with COPD with a smoking history without mucus-related symptoms (ie, cough, phlegm [silent…”
Get full text

Genetic regulators of sputum mucin concentration and their associations with COPD phenotypes by Van Buren, Eric, Radicioni, Giorgia, Lester, Sarah, O'Neal, Wanda K, Dang, Hong, Kasela, Silva, Garudadri, Suresh, Curtis, Jeffrey L, Han, MeiLan K, Krishnan, Jerry A, Wan, Emily S, Silverman, Edwin K, Hastie, Annette, Ortega, Victor E, Lappalainen, Tuuli, Nawijn, Martijn C, Berge, Maarten van den, Christenson, Stephanie A, Li, Yun, Cho, Michael H, Kesimer, Mehmet, Kelada, Samir N P

“…Hyper-secretion and/or hyper-concentration of mucus is a defining feature of multiple obstructive lung diseases, including chronic obstructive pulmonary…”
Get full text

Genome-Wide Association Study: Functional Variant rs2076295 Regulates Desmoplakin Expression in Airway Epithelial Cells by Hao, Yuan, Bates, Samuel, Mou, Hongmei, Yun, Jeong H, Pham, Betty, Liu, Jiangyuan, Qiu, Weiliang, Guo, Feng, Morrow, Jarrett D, Hersh, Craig P, Benway, Christopher J, Gong, Lu, Zhang, Yihan, Rosas, Ivan O, Cho, Michael H, Park, Jin-Ah, Castaldi, Peter J, Du, Fei, Zhou, Xiaobo

“…Genetic association studies have identified rs2076295 in association with idiopathic pulmonary fibrosis (IPF). We hypothesized that rs2076295 is the functional…”
Get full text

Proteomic networks and related genetic variants associated with smoking and chronic obstructive pulmonary disease by Konigsberg, Iain R, Vu, Thao, Liu, Weixuan, Litkowski, Elizabeth M, Pratte, Katherine A, Vargas, Luciana B, Gilmore, Niles, Abdel-Hafiz, Mohamed, Manichaikul, Ani, Cho, Michael H, Hersh, Craig P, DeMeo, Dawn L, Banaei-Kashani, Farnoush, Bowler, Russell P, Lange, Leslie A, Kechris, Katerina J

“…Studies have identified individual blood biomarkers associated with chronic obstructive pulmonary disease (COPD) and related phenotypes. However, complex…”
Get full text