Search Results - "Cho, Ken W.Y"

Measuring Absolute RNA Copy Numbers at High Temporal Resolution Reveals Transcriptome Kinetics in Development by Owens, Nick D.L., Blitz, Ira L., Lane, Maura A., Patrushev, Ilya, Overton, John D., Gilchrist, Michael J., Cho, Ken W.Y., Khokha, Mustafa K.

“…Transcript regulation is essential for cell function, and misregulation can lead to disease. Despite technologies to survey the transcriptome, we lack a…”
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Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis by Rothbächer, Ute, Laurent, Micheline N., Deardorff, Matthew A., Klein, Peter S., Cho, Ken W.Y., Fraser, Scott E.

“…Dishevelled (Dsh) induces a secondary axis and can translocate to the membrane when activated by Frizzleds; however, dominant‐negative approaches have not…”
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Production of a DPP activity gradient in the early Drosophila embryo through the opposing actions of the SOG and TLD proteins by Marqués, G, Musacchio, M, Shimell, M J, Wünnenberg-Stapleton, K, Cho, K W, O'Connor, M B

“…During early Drosophila embryogenesis, several zygotic gene products act to establish a posttranscriptional activity gradient of the morphogen DPP. Among these…”
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Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program by Charney, Rebekah M., Forouzmand, Elmira, Cho, Jin Sun, Cheung, Jessica, Paraiso, Kitt D., Yasuoka, Yuuri, Takahashi, Shuji, Taira, Masanori, Blitz, Ira L., Xie, Xiaohui, Cho, Ken W.Y.

“…The interplay between transcription factors and chromatin dictates gene regulatory network activity. Germ layer specification is tightly coupled with zygotic…”
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A gene regulatory program controlling early Xenopus mesendoderm formation: Network conservation and motifs by Charney, Rebekah M., Paraiso, Kitt D., Blitz, Ira L., Cho, Ken W.Y.

“…•Comprehensive Xenopus mesendoderm gene regulatory network (GRN).•Conserved regulatory connections in frog, fish, mouse, and human endoderm are…”
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Endodermal Maternal Transcription Factors Establish Super-Enhancers during Zygotic Genome Activation by Paraiso, Kitt D, Blitz, Ira L, Coley, Masani, Cheung, Jessica, Sudou, Norihiro, Taira, Masanori, Cho, Ken W Y

“…Elucidation of the sequence of events underlying the dynamic interaction between transcription factors and chromatin states is essential. Maternal…”
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Early Xenopus gene regulatory programs, chromatin states, and the role of maternal transcription factors by Paraiso, Kitt D, Cho, Jin S, Yong, Junseok, Cho, Ken W Y

“…For decades, the early development of the Xenopus embryo has been an essential model system to study the gene regulatory mechanisms that govern cellular…”
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An Atypical Canonical Bone Morphogenetic Protein (BMP) Signaling Pathway Regulates Msh Homeobox 1 (Msx1) Expression during Odontogenesis by Yang, Guobin, Yuan, Guohua, Ye, Wenduo, Cho, Ken W.Y., Chen, YiPing

“…Bone morphogenetic protein (BMP) signaling plays an essential role in early tooth development, evidenced by disruption of BMP signaling leading to an early…”
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Intracellular BMP Signaling Regulation in Vertebrates: Pathway or Network? by von Bubnoff, Andreas, Cho, Ken W.Y.

“…Bone morphogenetic proteins (BMPs), members of the TGF-β superfamily of secreted signaling molecules, have important functions in many biological contexts…”
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Opposing Nodal/Vg1 and BMP signals mediate axial patterning in embryos of the basal chordate amphioxus by Onai, Takayuki, Yu, Jr-Kai, Blitz, Ira L., Cho, Ken W.Y., Holland, Linda Z.

“…The basal chordate amphioxus resembles vertebrates in having a dorsal, hollow nerve cord, a notochord and somites. However, it lacks extensive gene…”
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BMP signaling is required for cell cleavage in preimplantation-mouse embryos by Reyes de Mochel, Nabora Soledad, Luong, Mui, Chiang, Michael, Javier, Anna L., Luu, Elizabeth, Toshihiko, Fujimori, MacGregor, Grant R., Cinquin, Olivier, Cho, Ken W.Y.

“…The mechanisms regulating cell division during development of the mouse pre-implantation embryo are poorly understood. We have investigated whether bone…”
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Foxh1/Nodal Defines Context-Specific Direct Maternal Wnt/β-Catenin Target Gene Regulation in Early Development by Afouda, Boni A., Nakamura, Yukio, Shaw, Sophie, Charney, Rebekah M., Paraiso, Kitt D., Blitz, Ira L., Cho, Ken W.Y., Hoppler, Stefan

“…Although Wnt/β-catenin signaling is generally conserved and well understood, the regulatory mechanisms controlling context-specific direct Wnt target gene…”
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Anterograde regulation of mitochondrial genes and FGF21 signaling by hepatic LSD1 by Cao, Yang, Tang, Lingyi, Du, Kang, Paraiso, Kitt, Sun, Qiushi, Liu, Zhengxia, Ye, Xiaolong, Fang, Yuan, Yuan, Fang, Chen, Hank, Chen, Yumay, Wang, Xiaorong, Yu, Clinton, Blitz, Ira L, Wang, Ping H, Huang, Lan, Cheng, Haibo, Lu, Xiang, Cho, Ken Wy, Seldin, Marcus, Fang, Zhuyuan, Yang, Qin

“…Mitochondrial biogenesis and function are controlled by anterograde regulatory pathways involving more than 1000 nuclear-encoded proteins. Transcriptional…”
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Mammalian BMP-1/Tolloid-Related Metalloproteinases, Including Novel Family Member Mammalian Tolloid-Like 2, Have Differential Enzymatic Activities and Distributions of Expression Relevant to Patterning and Skeletogenesis by Scott, Ian C., Blitz, Ira L., Pappano, William N., Imamura, Yasutada, Clark, Timothy G., Steiglitz, Barry M., Thomas, Christina L., Maas, Sarah A., Takahara, Kazuhiko, Cho, Ken W.Y., Greenspan, Daniel S.

“…Vertebrate bone morphogenetic protein 1 (BMP-1) and Drosophila Tolloid (TLD) are prototypes of a family of metalloproteases with important roles in various…”
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Enhancers by Cho, Ken W Y

“…Transcription of eukaryotic genes is an exceedingly sophisticated and complicated process, orchestrated by layers of control mechanisms involving a myriad of…”
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Phylogenetic footprinting and genome scanning identify vertebrate BMP response elements and new target genes by von Bubnoff, Andreas, Peiffer, Daniel A., Blitz, Ira L., Hayata, Tadayoshi, Ogata, Souichi, Zeng, Qiandong, Trunnell, Matthew, Cho, Ken W.Y.

“…The complex gene regulatory networks governed by growth factor signaling are still poorly understood. In order to accelerate the rate of progress in uncovering…”
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Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid by Cho, K W, Blumberg, B, Steinbeisser, H, De Robertis, E M

“…This study analyzes the function of the homeobox gene goosecoid in Xenopus development. First, we find that goosecoid mRNA distribution closely mimics the…”
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Gastrulation in the mouse: the role of the homeobox gene goosecoid by Blum, M, Gaunt, S J, Cho, K W, Steinbeisser, H, Blumberg, B, Bittner, D, De Robertis, E M

“…Mouse goosecoid is a homeobox gene expressed briefly during early gastrulation. Its mRNA accumulates as a patch on the side of the epiblast at the site where…”
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The Xfeb gene is directly upregulated by Zic1 during early neural development by Li, Shuzhao, Shin, Yongchol, Cho, Ken W.Y., Merzdorf, Christa S.

“…The transcription factor Zic1 plays important roles in patterning the neural plate in early vertebrate development. However, few genes that are regulated by…”
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The role of a Williams-Beuren syndrome-associated helix-loop-helix domain-containing transcription factor in activin/nodal signaling by Ring, Colleen, Ogata, Souichi, Meek, Lauren, Song, Jihwan, Ohta, Tatsuru, Miyazono, Kohei, Cho, Ken W Y

“…We investigated the regulation of the activin/nodal-inducible distal element (DE) of the Xenopus goosecoid (gsc) promoter. On the basis of its interaction with…”
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