Search Results - "Cho, Kathleen R."

Ovarian cancer by Cho, Kathleen R, Shih, Ie-Ming

“…Ovarian carcinomas are a heterogeneous group of neoplasms and are traditionally subclassified based on type and degree of differentiation. Although current…”
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The disparate origins of ovarian cancers: pathogenesis and prevention strategies by Karnezis, Anthony N., Cho, Kathleen R., Gilks, C. Blake, Pearce, Celeste Leigh, Huntsman, David G.

“…Ovarian cancer comprises a broad range of histologically and genetically different tumours. In this Opinion article, Karnezis et al . explore the different…”
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ARID1A-mutated ovarian cancers depend on HDAC6 activity by Bitler, Benjamin G., Wu, Shuai, Park, Pyoung Hwa, Hai, Yang, Aird, Katherine M., Wang, Yemin, Zhai, Yali, Kossenkov, Andrew V., Vara-Ailor, Ana, Rauscher III, Frank J., Zou, Weiping, Speicher, David W., Huntsman, David G., Conejo-Garcia, Jose R., Cho, Kathleen R., Christianson, David W., Zhang, Rugang

“…ARID1A , encoding a subunit of the SWI/SNF chromatin-remodelling complex, is the most frequently mutated epigenetic regulator across all human cancers. ARID1A…”
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Human ovarian carcinoma–associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production by McLean, Karen, Gong, Yusong, Choi, Yunjung, Deng, Ning, Yang, Kun, Bai, Shoumei, Cabrera, Lourdes, Keller, Evan, McCauley, Laurie, Cho, Kathleen R, Buckanovich, Ronald J

“…Accumulating evidence suggests that mesenchymal stem cells (MSCs) are recruited to the tumor microenvironment; however, controversy exists regarding their role…”
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High‐grade serous carcinomas arise in the mouse oviduct via defects linked to the human disease by Zhai, Yali, Wu, Rong, Kuick, Rork, Sessine, Michael S, Schulman, Stephanie, Green, Megan, Fearon, Eric R, Cho, Kathleen R

“…Recent studies have suggested that the most common and lethal type of ‘ovarian’ cancer, i.e. high‐grade serous carcinoma (HGSC), usually arises from epithelium…”
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Ovarian cancer update: lessons from morphology, molecules, and mice by Cho, Kathleen R

“…Ovarian carcinomas are a heterogeneous group of neoplasms. Pathologists currently employ a morphology-based classification system to divide ovarian carcinomas…”
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Mouse Model of Human Ovarian Endometrioid Adenocarcinoma Based on Somatic Defects in the Wnt/β-Catenin and PI3K/Pten Signaling Pathways by Wu, Rong, Hendrix-Lucas, Neali, Kuick, Rork, Zhai, Yali, Schwartz, Donald R., Akyol, Aytekin, Hanash, Samir, Misek, David E., Katabuchi, Hidetaka, Williams, Bart O., Fearon, Eric R., Cho, Kathleen R.

“…One histologic subtype of ovarian carcinoma, ovarian endometrioid adenocarcinoma (OEA), frequently harbors mutations that constitutively activate…”
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CD24+ Ovarian Cancer Cells Are Enriched for Cancer-Initiating Cells and Dependent on JAK2 Signaling for Growth and Metastasis by Burgos-Ojeda, Daniela, Wu, Rong, McLean, Karen, Chen, Yu-Chih, Talpaz, Moshe, Yoon, Euisik, Cho, Kathleen R, Buckanovich, Ronald J

“…Ovarian cancer is known to be composed of distinct populations of cancer cells, some of which demonstrate increased capacity for cancer initiation and/or…”
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p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes by Bommer, Guido T., Gerin, Isabelle, Feng, Ying, Kaczorowski, Andrew J., Kuick, Rork, Love, Robert E., Zhai, Yali, Giordano, Thomas J., Qin, Zhaohui S., Moore, Bethany B., MacDougald, Ormond A., Cho, Kathleen R., Fearon, Eric R.

“…In response to varied cell stress signals, the p53 tumor-suppressor protein activates a multitude of genes encoding proteins with functions in cell-cycle…”
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Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation by HINOI, Takao, AKYOL, Aytekin, THEISEN, Brian K, FERGUSON, David O, GREENSON, Joel K, WILLIAMS, Bart O, CHO, Kathleen R, FEARONT, Eric R

“…Mutations in the adenomatous polyposis coli (APC) gene are pivotal in colorectal tumorigenesis. Existing mouse intestinal tumor models display mainly small…”
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Sox9 Induction, Ectopic Paneth Cells, and Mitotic Spindle Axis Defects in Mouse Colon Adenomatous Epithelium Arising From Conditional Biallelic Apc Inactivation by Feng, Ying, Sentani, Kazuhiro, Wiese, Alexandra, Sands, Evan, Green, Maranne, Bommer, Guido T, Cho, Kathleen R, Fearon, Eric R

“…We generated transgenic mice in which human CDX2 gene elements control expression of a tamoxifen-regulated Cre protein ( CDX2P-CreER T2 ) to allow for…”
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Arid1a inactivation in an Apc- and Pten-defective mouse ovarian cancer model enhances epithelial differentiation and prolongs survival by Zhai, Yali, Kuick, Rork, Tipton, Courtney, Wu, Rong, Sessine, Michael, Wang, Zhong, Baker, Suzanne J, Fearon, Eric R, Cho, Kathleen R

“…Inactivation of the ARID1A tumour suppressor gene is frequent in ovarian endometrioid (OEC) and clear cell (OCCC) carcinomas, often in conjunction with…”
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Gene Expression Analysis of Preinvasive and Invasive Cervical Squamous Cell Carcinomas Identifies HOXC10 as a Key Mediator of Invasion by YALI ZHAI, KUICK, Rork, BIN NAN, OTA, Ichiro, WEISS, Stephen J, TRIMBLE, Cornelia L, FEARON, Eric R, CHO, Kathleen R

“…If left untreated, a subset of high-grade squamous intraepithelial lesions (HSIL) of the cervix will progress to invasive squamous cell carcinomas (SCC). To…”
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Preclinical Testing of PI3K/AKT/mTOR Signaling Inhibitors in a Mouse Model of Ovarian Endometrioid Adenocarcinoma by RONG WU, HU, Tom C, REHEMTULLA, Alnawaz, FEARON, Eric R, CHO, Kathleen R

“…Genetically engineered mouse (GEM) models of ovarian cancer that closely recapitulate their human tumor counterparts may be invaluable tools for preclinical…”
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Fibroblast growth factor 9 has oncogenic activity and is a downstream target of wnt signaling in ovarian endometrioid adenocarcinomas by HENDRIX, Neali D, RONG WU, KUICK, Rork, SCHWARTZ, Donald R, FEARON, Eric R, CHO, Kathleen R

“…Wnt signaling plays a key role in development and adult tissues via effects on cell proliferation, motility, and differentiation. The cellular response to Wnt…”
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Murine models of ovarian cancer for preclinical testing of targeted therapeutics: Has their time arrived? by Cho, Kathleen R.

“…Comment on: Wu R, et al. Clin Cancer Res 2011; 17:7359-72…”
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Two Distinct Categories of Focal Deletions in Cancer Genomes by Rajaram, Megha, Zhang, Jianping, Wang, Tim, Li, Jinyu, Kuscu, Cem, Qi, Huan, Kato, Mamoru, Grubor, Vladimir, Weil, Robert J, Helland, Aslaug, Borrenson-Dale, Anne-Lise, Cho, Kathleen R, Levine, Douglas A, Houghton, Alan N, Wolchok, Jedd D, Myeroff, Lois, Markowitz, Sanford D, Lowe, Scott W, Zhang, Michael, Krasnitz, Alex, Lucito, Robert, Mu, David, Powers, R Scott

“…One of the key questions about genomic alterations in cancer is whether they are functional in the sense of contributing to the selective advantage of tumor…”
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Loss of Estrogen Receptor 1 Enhances Cervical Cancer Invasion by Zhai, Yali, Bommer, Guido T, Feng, Ying, Wiese, Alexandra B, Fearon, Eric R, Cho, Kathleen R

“…If left untreated, some cervical high-grade squamous intraepithelial lesions will progress to invasive squamous cell carcinoma (SCC), but the molecular events…”
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Tight Junction Proteins Claudin-3 and Claudin-4 Are Frequently Overexpressed in Ovarian Cancer but Not in Ovarian Cystadenomas by Rangel, Leticia B A, Agarwal, Rachana, D'Souza, Theresa, Pizer, Ellen S, Alò, Piero L, Lancaster, Wayne D, Gregoire, Lucie, Schwartz, Donald R, Cho, Kathleen R, Morin, Patrice J

“…Purpose: Claudin proteins represent a large family of integral membrane proteins crucial for tight junction (TJ) formation and function. Claudins have been…”
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Tissue-Specific Effects of Reduced β-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium by Feng, Ying, Sakamoto, Naoya, Wu, Rong, Liu, Jie-Yu, Wiese, Alexandra, Green, Maranne E, Green, Megan, Akyol, Aytekin, Roy, Badal C, Zhai, Yali, Cho, Kathleen R, Fearon, Eric R

“…Adenomatous polyposis coli (APC) inactivating mutations are present in most human colorectal cancers and some other cancers. The APC protein regulates the…”
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