Search Results - "Cho, Goang Won"

Autophagy: An evolutionarily conserved process in the maintenance of stem cells and aging by Vijayakumar, Karthikeyan, Cho, Goang‐Won

“…Autophagy is an evolutionarily conserved process that degrades and recycles defective organelles, toxic proteins, and various other aggregates on the…”
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Caloric restriction maintains stem cells through niche and regulates stem cell aging by Maharajan, Nagarajan, Vijayakumar, Karthikeyan, Jang, Chul Ho, Cho, Goang-Won

“…The functional loss of adult stem cells is a major cause of aging and age-related diseases. Changes in the stem cell niche, increased energy metabolic rate,…”
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The tubulin deacetylase sirtuin-2 regulates neuronal differentiation through the ERK/CREB signaling pathway by Jeong, Sin-Gu, Cho, Goang-Won

“…Modification of microtubule (MT) dynamics is important for diverse aspects of cellular function including differentiation, cargo trafficking, migration, and…”
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Reduced sirtuin 1/adenosine monophosphate‐activated protein kinase in amyotrophic lateral sclerosis patient‐derived mesenchymal stem cells can be restored by resveratrol by Yun, Young Chan, Jeong, Sin‐Gu, Kim, Seung Hyun, Cho, Goang‐Won

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor neuron system. Our previous study has shown that bone…”
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Metformin promotes neuronal differentiation and neurite outgrowth through AMPK activation in human bone marrow–mesenchymal stem cells by Ahn, Min‐Ji, Cho, Goang‐Won

“…Metformin is an AMP‐activated kinase (AMPK) activator that plays a role in glucose energy metabolism and cell protection. It is widely used to treat several…”
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Anti-senescence effects of DNA methyltransferase inhibitor RG108 in human bone marrow mesenchymal stromal cells by Oh, Youn Seo, Jeong, Sin-Gu, Cho, Goang-Won

“…Alteration of DNA methylation is highly associated with ageing and ageing‐related diseases. Remedy of the altered methylation pattern may provide beneficial…”
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Valproic acid promotes neuronal differentiation by induction of neuroprogenitors in human bone-marrow mesenchymal stromal cells by Jeong, Sin-Gu, Ohn, Takbum, Kim, Seung Hyun, Cho, Goang-Won

“…•The expression of neuronal progenitor marker genes is increased by VPA in hBM-MSCs.•Neuron-like morphological changes occur with VPA-pretreatment in…”
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Accumulation of apoptosis-insensitive human bone marrow-mesenchymal stromal cells after long-term expansion by Jeong, Sin-Gu, Cho, Goang-Won

“…Cells undergo replicative senescence during in vitro expansion, which is induced by the accumulation of cellular damage caused by excessive reactive oxygen…”
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Trichostatin a modulates intracellular reactive oxygen species through SOD2 and FOXO1 in human bone marrow-mesenchymal stem cells by Jeong, Sin-Gu, Cho, Goang-Won

“…Engraft cells are often exposed to oxidative stress and inflammation; therefore, any factor that can provide the stem cells resistance to these stresses may…”
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Effects of valproic acid on the expression of trophic factors in human bone marrow mesenchymal stromal cells by Cho, Goang-Won, Kang, Byung Yong, Kim, Kyung-Suk, Kim, Seung Hyun

“…► Various trophic factors are significantly increased in valproate-treated hBM-MSCs (VPA-MSCs). ► VPA-MSCs showed increased protective effects against…”
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The neuroprotective effect of erythropoietin-transduced human mesenchymal stromal cells in an animal model of ischemic stroke by Cho, Goang-Won, Koh, Seong-Ho, Kim, Mi-Hwa, Yoo, A. Rum, Noh, Min Young, Oh, Sechul, Kim, Seung Hyun

“…Abstract Erythropoietin (EPO) exhibits diverse cellular functions, including neurotrophic, anti-oxidant, anti-apoptotic, and anti-inflammatory effects in…”
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Erythropoietin increases the motility of human bone marrow-multipotent stromal cells (hBM-MSCs) and enhances the production of neurotrophic factors from hBM-MSCs by Koh, Seong-Ho, Noh, Min Young, Cho, Goang Won, Kim, Kyung Suk, Kim, Seung Hyun

“…Cell therapy has been extensively studied as an approach to repair damage in nervous system diseases. Multipotent stromal cells [MSCs] are well known to have…”
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Functional restoration of replicative senescent mesenchymal stem cells by the brown alga Undaria pinnatifida by Jeong, Sin-Gu, Oh, Youn Seo, Joe, I-Seul, Jeong, So Young, Cho, Hyo Moon, Lee, Jun Sik, Oh, Won Keun, Cho, Tae Oh, Cho, Goang-Won

“…The brown alga Undaria pinnatifida, which is called Mi-Yoek in Korea, has been traditionally consumed as a health food in East Asian countries. Recent studies…”
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Inhibitory Effects of Cilostazol on Proliferation of Vascular Smooth Muscle Cells (VSMCs) Through Suppression of the ERK1/2 Pathway by Yoo, A Rum, Koh, Seong-Ho, Cho, Goang Won, Kim, Seung H

“…Aim: The abnormal proliferation of vascular smooth muscle cells (VSMCs) in arterial walls is an important pathogenic factor of vascular disorders such as…”
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Resveratrol-induced SIRT1 activation promotes neuronal differentiation of human bone marrow mesenchymal stem cells by Joe, I-Seul, Jeong, Sin-Gu, Cho, Goang-Won

“…•The expression of neuronal progenitor marker genes is increased by RSV in hBM-MSCs.•Neuron-like morphological changes occur with RSV-pretreatment in…”
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Functional Restoration of Amyotrophic Lateral Sclerosis Patient-Derived Mesenchymal Stromal Cells Through Inhibition of DNA Methyltransferase by Oh, Youn Seo, Kim, Seung Hyun, Cho, Goang-Won

“…Alteration of DNA methylation is highly associated with aging and neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS). Remedying these…”
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Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-β-induced neuronal cell death by Noh, Min-Young, Koh, Seong-Ho, Kim, Youngchul, Kim, Hyun Young, Cho, Goang Won, Kim, Seung Hyun

“…Acetylcholinesterase inhibitors (AChE-inhibitors) are used for the treatment of Alzheimer's disease. Recently, the AChE-inhibitor donepezil was found to have…”
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Memantine Attenuates Salicylate-induced Tinnitus Possibly by Reducing NR2B Expression in Auditory Cortex of Rat by Jang, Chul Ho, Lee, Sueun, Park, Il Yong, Song, Anji, Moon, Changjong, Cho, Goang-Won

“…Memantine, a noncompetitive antagonist of the -methyl-D-aspartate (NMDA) receptor, suppresses the release of excessive levels of glutamate that may induce…”
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G9a inhibition promotes neuronal differentiation of human bone marrow mesenchymal stem cells through the transcriptional induction of RE-1 containing neuronal specific genes by Kim, Ho-Tae, Jeong, Sin-Gu, Cho, Goang-Won

“…Recent studies have shown that epigenomic modifications are significantly associated with neuronal differentiation. Many neuronal specific genes contain the…”
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Endogenous ROS levels are increased in replicative senescence in human bone marrow mesenchymal stromal cells by Jeong, Sin-Gu, Cho, Goang-Won

“…Cellular senescence is characterized by functional decline induced by cumulative damage to DNA, proteins, lipids, and carbohydrates. Previous studies have…”
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