Search Results - "Chloupková, Maja"

MDL1 is a High Copy Suppressor of ATM1: Evidence for a Role in Resistance to Oxidative Stress by Chloupková, Maja, LeBard, Linda S, Koeller, David M

“…The yeast ATM1 gene is essential for normal cellular iron homeostasis. Deletion of ATM1 results in mitochondrial iron accumulation and increased sensitivity to…”
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Abnormal iron uptake and liver cancer by Chen, Juxing, Chloupkova, Maja

“…Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Iron overload represents a significant risk factor in the development of HCC…”
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HFE Modulates Transferrin Receptor 2 Levels in Hepatoma Cells via Interactions That Differ from Transferrin Receptor 1-HFE Interactions by Chen, Juxing, Chloupková, Maja, Gao, Junwei, Chapman-Arvedson, Tara L., Enns, Caroline A.

“…Mutations in the transmembrane glycoproteins transferrin receptor 2 (TfR2) and HFE are associated with hereditary hemochromatosis. Interactions between HFE and…”
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Expression of 25 Human ABC Transporters in the Yeast Pichia pastoris and Characterization of the Purified ABCC3 ATPase Activity by Chloupková, Maja, Pickert, Amanda, Lee, Jyh-Yeuan, Souza, Shiloe, Trinh, Yenphuong T, Connelly, Sara M, Dumont, Mark E, Dean, Michael, Urbatsch, Ina L

“…Human ATP-binding cassette (ABC) transporters comprise a family of 48 membrane-spanning transport proteins, many of which are associated with genetic diseases…”
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Stoichiometries of transferrin receptors 1 and 2 in human liver by Chloupková, Maja, Zhang, An-Sheng, Enns, Caroline A.

“…Mutations in either the hereditary hemochromatosis protein, HFE, or transferrin receptor 2, TfR2, result in a similarly severe form of the most common type of…”
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The mechanism by which the TfR2/HFE complex affects iron homeostasis by Worthen, Christal Anna, Chloupková, Maja, Noguchi, Ken, Enns, Caroline A

“…Abstract only Iron homeostasis is tightly controlled. Since there is no regulated way of excreting excess iron, levels are finely tuned through dietary uptake…”
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Purification and ATP Hydrolysis of the Putative Cholesterol Transporters ABCG5 and ABCG8 by Wang, Zhanling, Stalcup, Lindsay D, Harvey, Brandy J, Weber, Joachim, Chloupkova, Maja, Dumont, Mark E, Dean, Michael, Urbatsch, Ina L

“…Mutations in the ATP-binding cassette (ABC) transporters ABCG5 and ABCG8 lead to sitosterolemia, a disorder characterized by sterol accumulation and premature…”
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The mitochondrial ABC transporter Atm1p functions as a homodimer by Chloupková, Maja, Reaves, Scott K, LeBard, Linda M, Koeller, David M

“…The ATP-binding cassette (ABC) transporters constitute one of the largest families of proteins in evolution. The ATM1 gene of the yeast Saccharomyces…”
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Changes in the Carboxyl Terminus of the β Subunit of Human Propionyl-CoA Carboxylase Affect the Oligomer Assembly and Catalysis: Expression and Characterization of Seven Patient-Derived Mutant Forms of PCC in Escherichia coli by Chloupková, Maja, Ravn, Kirstine, Schwartz, Marianne, Kraus, Jan P.

“…Propionyl-CoA carboxylase (PCC) catalyzes the biotin-dependent carboxylation of propionyl-CoA to d-methylmalonyl-CoA in the mitochondrial matrix. Human PCC is…”
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Propionic acidemia: Analysis of mutant propionyl-CoA carboxylase enzymes expressed inEscherichia coli by Chloupkova, Maja, Maclean, Kenneth N., Alkhateeb, Asem, Kraus, Jan P.

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Propionic acidemia: Analysis of mutant propionyl-CoA carboxylase enzymes expressed in Escherichia coli by Chloupkova, Maja, Maclean, Kenneth N., Alkhateeb, Asem, Kraus, Jan P.

“…Deficiency of propionyl‐CoA carboxylase (PCC) results in propionic acidemia, an autosomal recessive disorder characterized by ketoacidosis sufficiently severe…”
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High Incidence of Propionic Acidemia in Greenland Is Due to a Prevalent Mutation, 1540insCCC, in the Gene for the β-Subunit of Propionyl CoA Carboxylase by Ravn, Kirstine, Chloupkova, Maja, Christensen, Ernst, Brandt, Niels Jacob, Simonsen, Henrik, Kraus, Jan P., Nielsen, Inge Merete, Skovby, Flemming, Schwartz, Marianne

“…Propionyl CoA carboxylase (PCC) is a mitochondrial, biotin-dependent enzyme involved in the catabolism of amino acids, odd-chain fatty acids, and other…”
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