Search Results - "Chlopicki, S"

Atomic Force Microscopy Reveals the Dynamic Morphology of Fenestrations in Live Liver Sinusoidal Endothelial Cells by Zapotoczny, B., Szafranska, K., Owczarczyk, K., Kus, E., Chlopicki, S., Szymonski, M.

“…Here, we report an atomic force microscopy (AFM)-based imaging method for resolving the fine nanostructures (e.g., fenestrations) in the membranes of live…”
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Preservation of left ventricle peak and mean pulse flow blood velocity despite progressive deterioration of cardiac function in a chronic heart failure murine model by Tyrankiewicz, U, Kwiatkowski, G, Chlopicki, S

“…The goal of this study was to assess the alterations in left ventricle (LV) blood flow velocity patterns in relation to progressive impairment of cardiac…”
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Vascular ATGL-dependent lipolysis and the activation of cPLA2–PGI2 pathway protect against postprandial endothelial dysfunction by Sternak, M., Stojak, M., Banasik, T., Kij, A., Bar, A., Pacia, M. Z., Wojnar-Lason, K., Chorazy, N., Mohaissen, T., Marczyk, B., Czyzynska-Cichon, I., Berkimbayeva, Z., Mika, A., Chlopicki, S.

“…Adipose triglyceride lipase (ATGL) is involved in lipolysis and displays a detrimental pathophysiological role in cardio-metabolic diseases. However, the…”
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Vibrational spectroscopy-based quantification of liver steatosis by Szafraniec, E., Tott, S., Kus, E., Augustynska, D., Jasztal, A., Filipek, A., Chlopicki, S., Baranska, M.

“…The liver plays a central role in lipid metabolism, and abnormal lipid accumulation in the liver is a key feature of Non-Alcoholic Fatty Liver Disease. In…”
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FT-IR imaging for quantitative determination of liver fat content in non-alcoholic fatty liver by Kochan, K, Maslak, E, Chlopicki, S, Baranska, M

“…In this work we apply FT-IR imaging of large areas of liver tissue cross-section samples (∼5 cm × 5 cm) for quantitative assessment of steatosis in murine…”
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Aromatic sulphonamides of aziridine-2-carboxylic acid derivatives as novel PDIA1 and PDIA3 inhibitors by Zelencova-Gopejenko, D., Andrianov, V., Domracheva, I., Kanepe-Lapsa, I., Milczarek, M., Stojak, M., Przyborowski, K., Fedak, F. A., Walczak, M., Kramkowski, K., Wietrzyk, J., Chlopicki, S., Kalvins, I.

“…In this study, we report a series of newly synthesised sulphonamides of aziridine-2-carboxylic acid (Az-COOH) ester and amide analogues as potent protein…”
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1‐Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti‐thrombotic activity mediated by a cyclooxygenase‐2/prostacyclin pathway by Chlopicki, S, Swies, J, Mogielnicki, A, Buczko, W, Bartus, M, Lomnicka, M, Adamus, J, Gebicki, J

“…Background and purpose: 1‐methylnicotinamide (MNA) has been considered to be an inactive metabolite of nicotinamide. Here we assessed the anti‐thrombotic…”
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Raman spectroscopic studies of vitamin A content in the liver: a biomarker of healthy liver by Kochan, K, Marzec, K M, Maslak, E, Chlopicki, S, Baranska, M

“…Confocal Raman microspectroscopy was used in this study to identify hepatic stellate cells (HSCs) from healthy mice and mice with untreated and treated liver…”
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Alterations in NO- and PGI2- dependent function in aorta in the orthotopic murine model of metastatic 4T1 breast cancer: relationship with pulmonary endothelial dysfunction and systemic inflammation by Buczek, E, Denslow, A, Mateuszuk, L, Proniewski, B, Wojcik, T, Sitek, B, Fedorowicz, A, Jasztal, A, Kus, E, Chmura- Skirlinska, A, Gurbiel, R, Wietrzyk, J, Chlopicki, S

“…Background Patients with cancer develop endothelial dysfunction and subsequently display a higher risk of cardiovascular events. The aim of the present work…”
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Label-free spectroscopic characterization of live liver sinusoidal endothelial cells (LSECs) isolated from the murine liver by Kochan, K, Kus, E, Filipek, A, Szafrańska, K, Chlopicki, S, Baranska, M

“…Liver sinusoidal endothelial cells (LSECs) represent a highly specialized and unique type of endothelial cell in terms of their morphology and function. The…”
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Nuclear accumulation of anthracyclines in the endothelium studied by bimodal imaging: fluorescence and Raman microscopy by Majzner, K, Wojcik, T, Szafraniec, E, Lukawska, M, Oszczapowicz, I, Chlopicki, S, Baranska, M

“…Anthracycline antibiotics display genotoxic activity towards cancer cells but their clinical utility is limited by their cardiac and vascular toxicity. The aim…”
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Morphology and force probing of primary murine liver sinusoidal endothelial cells by Zapotoczny, B., Owczarczyk, K., Szafranska, K., Kus, E., Chlopicki, S., Szymonski, M.

“…Liver sinusoidal endothelial cells (LSECs) represent unique type of endothelial cells featured by their characteristic morphology, ie, lack of a basement…”
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A novel combined glucocorticoid-mineralocorticoid receptor selective modulator markedly prevents weight gain and fat mass expansion in mice fed a high-fat diet by Mammi, C, Marzolla, V, Armani, A, Feraco, A, Antelmi, A, Maslak, E, Chlopicki, S, Cinti, F, Hunt, H, Fabbri, A, Caprio, M

“…Background: We have previously shown that antagonism of the mineralocorticoid receptor (MR) results in a potent antiadipogenic activity, in vitro and in vivo…”
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Biochemical changes of the endothelium in the murine model of NO-deficient hypertension by Pacia, M Z, Mateuszuk, L, Chlopicki, S, Baranska, M, Kaczor, A

“…The main spectral differences between the biochemical compositions of the vascular endothelium of control, hypertensive NO-deficient, and NO-deficient mice…”
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Identification of a biochemical marker for endothelial dysfunction using Raman spectroscopy by Rygula, A, Pacia, M Z, Mateuszuk, L, Kaczor, A, Kostogrys, R B, Chlopicki, S, Baranska, M

“…In the present work, we propose the spectroscopic approach to identify biochemical alterations in endothelial dysfunction. The method is based on the…”
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Effects of a single bout of strenuous exercise on platelet activation in female ApoE/LDLR−/− mice by Przyborowski, K., Kassassir, H., Wojewoda, M., Kmiecik, K., Sitek, B., Siewiera, K., Zakrzewska, A., Rudolf, A. M., Kostogrys, R., Watala, C., Zoladz, J. A., Chlopicki, S.

“…Strenuous physical exercise leads to platelet activation that is normally counterbalanced by the production of endothelium-derived anti-platelet mediators,…”
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Raman microimaging of murine lungs: insight into the vitamin A content by Marzec, K M, Kochan, K, Fedorowicz, A, Jasztal, A, Chruszcz-Lipska, K, Dobrowolski, J Cz, Chlopicki, S, Baranska, M

“…The composition of the lung tissue of mice was investigated using Raman confocal microscopy at 532 nm excitation wavelength and was supported with various…”
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Effects of Low Carbohydrate High Protein (LCHP) diet on atherosclerotic plaque phenotype in ApoE/LDLR−/− mice: FT-IR and Raman imaging by Wrobel, T. P., Marzec, K. M., Chlopicki, S., Maślak, E., Jasztal, A., Franczyk-Żarów, M., Czyżyńska-Cichoń, I., Moszkowski, T., Kostogrys, R. B., Baranska, M.

“…Low Carbohydrate High Protein (LCHP) diet displays pro-atherogenic effects, however, the exact mechanisms involved are still unclear. Here, with the use of…”
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Exercise capacity and cardiac hemodynamic response in female ApoE/LDLR−/− mice: a paradox of preserved V’O2max and exercise capacity despite coronary atherosclerosis by Wojewoda, M., Tyrankiewicz, U., Gwozdz, P., Skorka, T., Jablonska, M., Orzylowska, A., Jasinski, K., Jasztal, A., Przyborowski, K., Kostogrys, R. B., Zoladz, J. A., Chlopicki, S.

“…We assessed exercise performance, coronary blood flow and cardiac reserve of female ApoE/LDLR −/− mice with advanced atherosclerosis compared with age-matched,…”
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Short-term treatment with nitrate is not sufficient to induce in vivo antithrombotic effects in rats and mice by Kramkowski, K., Leszczynska, A., Przyborowski, K., Proniewski, B., Marcinczyk, N., Rykaczewska, U., Jarmoc, D., Chabielska, E., Chlopicki, S.

“…In humans, short-term supplementation with nitrate is hypotensive and inhibits platelet aggregation via an nitric oxide (NO)-dependent mechanism. In the…”
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