Search Results - "Chizh, B."

NMDA antagonists and neuropathic pain--multiple drug targets and multiple uses by Chizh, B A, Headley, P M

“…NMDA (N-methyl-D-aspartate) receptors are one class of ionotropic receptor for the ubiquitous excitatory neurotransmitter L-glutamate. The receptor is made up…”
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Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers by Chizh, B.A., Göhring, M., Tröster, A., Quartey, G.K., Schmelz, M., Koppert, W.

“…Central sensitization is an important mechanism of neuropathic pain; its human models could be useful for early detection of efficacy of novel treatments. The…”
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P2X Receptors and Nociception by Chizh, B A, Illes, P

“…The potential importance for nociception of P2X receptors, the ionotropic receptors activated by ATP, is underscored by the variety of pain states in which…”
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The effects of the TRPV1 receptor antagonist SB-705498 on trigeminovascular sensitisation and neurotransmission by Lambert, G. A., Davis, J. B., Appleby, J. M., Chizh, B. A., Hoskin, K. L., Zagami, A. S.

“…This report examines the effect of the transient receptor potential vanilloid 1 receptor antagonist SB-705498 on neurotransmission and inflammation-induced…”
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NMDA receptor antagonists as analgesics: focus on the NR2B subtype by Chizh, Boris A, Headley, P.Max, Tzschentke, Thomas M

“…Ifenprodil and a group of related compounds are selective antagonists of NR2B-containing NMDA receptors. These compounds are antinociceptive in a variety of…”
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Effective electromagnetic noise cancellation with beamformers and synthetic gradiometry in shielded and partly shielded environments by Adjamian, P., Worthen, S.F., Hillebrand, A., Furlong, P.L., Chizh, B.A., Hobson, A.R., Aziz, Q., Barnes, G.R.

“…The major challenge of MEG, the inverse problem, is to estimate the very weak primary neuronal currents from the measurements of extracranial magnetic fields…”
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Novel approaches to targeting glutamate receptors for the treatment of chronic pain: review article by Chizh, B A

“…Glutamatergic mechanisms are implicated in acute and chronic pain, and there is a great diversity of glutamate receptors that can be used as targets for novel…”
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A Lack of Antinociceptive or Antiinflammatory Effect of Botulinum Toxin A in an Inflammatory Human Pain Model by Sycha, Thomas, Samal, Doris, Chizh, Boris, Lehr, Stephan, Gustorff, Burkhard, Schnider, Peter, Auff, Eduard

“…Several in vitro and in vivo investigations have shown that botulinum toxin A (BoNT/A) can inhibit the release of substance P and excitatory amino acids…”
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Rofecoxib attenuates both primary and secondary inflammatory hyperalgesia: a randomized, double blinded, placebo controlled crossover trial in the UV-B pain model by Sycha, Thomas, Anzenhofer, Sebastian, Lehr, Stephan, Schmetterer, Leopold, Chizh, Boris, Eichler, Hans-Georg, Gustorff, Burkhard

“…The analysis of drug's influence on peripheral and central sensitisation can give useful information about its mode of action and can lead to more efficacy in…”
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421 COMPARISON OF 4-SPOKE VERSUS 8-SPOKE METHODS FOR ANALYSING EXPERIMENTAL HYPERALGESIA AND ALLODYNIA by Robertson, J., Ackland, J., Robertson, D., O'Donnell, M., Bird, N., Chizh, B.

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400 THE EFFECTS OF PARACETAMOL AND THE NK1 ANTAGONIST APREPITANT ON THE UVB-EVOKED CUTANEOUS HYPERALGESIA IN HEALTHY VOLUNTEERS by Boyle, Y, Robertson, D, O'Donnell, M, Griffiths, L, Hewens, D, Cookson, L, Ramakrishnan, Y, Chizh, B

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408 A PILOT STUDY OF MARKERS OF PERIPHERAL AFFERENT ACTIVATION AND NEUROGENIC INFLAMMATION IN THE ELECTRICAL HYPERALGESIA MODEL USING MICRODIALYSIS by Robertson, D., O'Donnell, M., Boyle, Y., Smith, L., Robertson, J., Ramakrishnan, Y., Cookson, L., Chizh, B.

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702 A RANDOMISED, TWO-PERIOD CROSS-OVER STUDY TO INVESTIGATE THE EFFICACY OF THE TRPV1 ANTAGONIST SB-705498 IN ACUTE MIGRAINE by Chizh, B., Palmer, J., Lai, R., Guillard, F., Bullman, J., Baines, A., Napolitano, A., Appleby, J.

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Homotopic stimulation can reduce the area of allodynia in patients with neuropathic pain by Love‐Jones, S. J., Steeds, C. E., Besson, M., Brook, P., Chizh, B. A., Pickering, A. E.

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Supraspinal vs spinal sites of the antinociceptive action of the subtype-selective NMDA antagonist ifenprodil by Chizh, Boris A, Reißmüller, Elke, Schlütz, Harald, Scheede, Manuela, Haase, Günter, Englberger, Werner

“…The N-methyl-D-aspartate (NMDA) antagonist ifenprodil and several structurally related compounds are highly selective for the NR2B-containing receptor subtype…”
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Antinociception and (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid antagonism by gabapentin in the rat spinal cord in vivo by Chizh, B A, Scheede, M, Schlütz, H

“…Gabapentin, a novel anticonvulsant and analgesic with an unknown mechanism of action, was tested on spinal dorsal horn neurone activity evoked by…”
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401 THE EFFECTS OF INTRAVENOUS REMIFENTANIL ON PAIN OF DIFFERENT MODALITIES: A RANDOMISED CONTROLLED STUDY IN HEALTHY VOLUNTEERS by Yu, K.S, Price, J, Mistry, P, Chizh, B

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The N-methyl- d-aspartate antagonistic and opioid components of d-methadone antinociception in the rat spinal cord by Chizh, Boris A, Schlütz, Harald, Scheede, Manuela, Englberger, Werner

“…The d-enantiomer of the opioid methadone is a weak opioid with low micromolar affinity to the N-methyl- d-aspartate (NMDA) receptor. We have investigated the…”
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Stimulus intensity, cell excitation and the N-methyl- d-aspartate receptor component of sensory responses in the rat spinal cord in vivo by Chizh, B.A, Cumberbatch, M.J, Herrero, J.F, Stirk, G.C, Headley, P.M

“…The importance of receptors for N-methyl- d-aspartate in synaptic plasticity and in triggering long-term pronociceptive changes is explained by their…”
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Modulation of excitatory amino acid responses by tachykinins and selective tachykinin receptor agonists in the rat spinal cord by Cumberbatch, Michael J., Chizh, Boris A., MaxHeadley, P.

“…1 The effects of tachykinins and agonists selective for the three subtypes of neurokinin (NK) receptor have been tested on spinal neuronal responses both to…”
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