Search Results - "Chivero, Ernest T"

Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics by Thangaraj, Annadurai, Periyasamy, Palsamy, Guo, Ming-Lei, Chivero, Ernest T., Callen, Shannon, Buch, Shilpa

“…Although cocaine exposure has been shown to potentiate neuroinflammation by upregulating glial activation in the brain, the role of mitophagy in this process…”
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Targeting endoplasmic reticulum stress and autophagy as therapeutic approaches for neurological diseases by Thangaraj, Annadurai, Sil, Susmita, Tripathi, Ashutosh, Chivero, Ernest T, Periyasamy, Palsamy, Buch, Shilpa

“…Neurological diseases are multifactorial, devastating diseases that are causative for various neurodegenerative disorders. Emerging evidence points that…”
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Involvement of lncRNA TUG1 in HIV-1 Tat-Induced Astrocyte Senescence by Pillai, Prakash P, Kannan, Muthukumar, Sil, Susmita, Singh, Seema, Thangaraj, Annadurai, Chivero, Ernest T, Dagur, Raghubendra Singh, Tripathi, Ashutosh, Hu, Guoku, Periyasamy, Palsamy, Buch, Shilpa

“…HIV-1 infection in the era of combined antiretroviral therapy has been associated with premature aging. Among the various features of HIV-1 associated…”
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HIV TAT-mediated microglial senescence: Role of SIRT3-dependent mitochondrial oxidative stress by Thangaraj, Annadurai, Chivero, Ernest T., Tripathi, Ashutosh, Singh, Seema, Niu, Fang, Guo, Ming-Lei, Pillai, Prakash, Periyasamy, Palsamy, Buch, Shilpa

“…The advent of combined antiretroviral treatment (cART) as a treatment for HIV-1 infection has not only resulted in a dramatic decrease in the peripheral viral…”
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Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia by Chivero, Ernest T, Liao, Ke, Niu, Fang, Tripathi, Ashutosh, Tian, Changhai, Buch, Shilpa, Hu, Guoku

“…MicroRNA-124 (miR-124), a brain-enriched microRNA, is known to regulate microglial quiescence. Psychostimulants such as cocaine have been shown to activate…”
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Extracellular Vesicles in Viral Infections of the Nervous System by Kutchy, Naseer A, Peeples, Eric S, Sil, Susmita, Liao, Ke, Chivero, Ernest T, Hu, Guoku, Buch, Shilpa

“…Almost all types of cells release extracellular vesicles (EVs) into the extracellular space. EVs such as exosomes and microvesicles are membrane-bound vesicles…”
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N-Acetylcysteine Reverses Antiretroviral-Mediated Microglial Activation by Attenuating Autophagy-Lysosomal Dysfunction by Tripathi, Ashutosh, Thangaraj, Annadurai, Chivero, Ernest T, Periyasamy, Palsamy, Burkovetskaya, Maria E, Niu, Fang, Guo, Ming-Lei, Buch, Shilpa

“…Successful suppression of viral replication by combined antiretroviral therapy (cART) in HIV-1 infected individuals is paradoxically also accompanied by an…”
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Role of Inflammasomes in HIV-1 and Drug Abuse Mediated Neuroinflammaging by Sil, Susmita, Niu, Fang, Chivero, Ernest T, Singh, Seema, Periyasamy, Palsamy, Buch, Shilpa

“…Despite the effectiveness of combined antiretroviral therapy (cART) in suppressing virus replication, chronic inflammation remains one of the cardinal features…”
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Antiretroviral-Mediated Microglial Activation Involves Dysregulated Autophagy and Lysosomal Dysfunction by Tripathi, Ashutosh, Thangaraj, Annadurai, Chivero, Ernest T, Periyasamy, Palsamy, Callen, Shannon, Burkovetskaya, Maria E, Guo, Ming-Lei, Buch, Shilpa

“…In the era of combined antiretroviral therapy (cART), as infected individuals continue to have longer lifespans, there is also an increased prevalence of…”
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Corrigendum to “HIV TAT-mediated microglial senescence: Role of SIRT3-dependent mitochondrial oxidative stress” [Redox Biol. 40 (2021) 101843] by Thangaraj, Annadurai, Chivero, Ernest T., Tripathi, Ashutosh, Singh, Seema, Niu, Fang, Guo, Ming-Lei, Pillai, Prakash, Periyasamy, Palsamy, Buch, Shilpa

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PDGF/PDGFR axis in the neural systems by Sil, Susmita, Periyasamy, Palsamy, Thangaraj, Annadurai, Chivero, Ernest T., Buch, Shilpa

“…Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are expressed in several cell types including the brain cells such as neuronal…”
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HIV-1 Tat Primes and Activates Microglial NLRP3 Inflammasome-Mediated Neuroinflammation by Chivero, Ernest T, Guo, Ming-Lei, Periyasamy, Palsamy, Liao, Ke, Callen, Shannon E, Buch, Shilpa

“…Neuroinflammation associated with HIV-1 infection is a problem affecting ∼50% of HIV-infected individuals. NLR family pyrin domain containing 3 (NLRP3)…”
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Substance use, microbiome and psychiatric disorders by Chivero, Ernest T., Sil, Susmita, Kumar, Mohit, Buch, Shilpa

“…Accumulating evidence from several studies has shown association between substance use, dysregulation of the microbiome and psychiatric disorders such as…”
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Tropism of human pegivirus (formerly known as GB virus C/hepatitis G virus) and host immunomodulation: insights into a highly successful viral infection by Chivero, Ernest T, Stapleton, Jack T

“…Human pegivirus (HPgV; originally called GB virus C/hepatitis G virus) is an RNA virus within the genus Pegivirus of the family Flaviviridae that commonly…”
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Cocaine Induces Inflammatory Gut Milieu by Compromising the Mucosal Barrier Integrity and Altering the Gut Microbiota Colonization by Chivero, Ernest T., Ahmad, Rizwan, Thangaraj, Annadurai, Periyasamy, Palsamy, Kumar, Balawant, Kroeger, Elisa, Feng, Dan, Guo, Ming-Lei, Roy, Sabita, Dhawan, Punita, Singh, Amar B., Buch, Shilpa

“…Cocaine use disorder (CUD), a major health crisis, has traditionally been considered a complication of the CNS; however, it is also closely associated with…”
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HIV-1 and drug abuse comorbidity: Lessons learned from the animal models of NeuroHIV by Sil, Susmita, Thangaraj, Annadurai, Chivero, Ernest T., Niu, Fang, Kannan, Muthukumar, Liao, Ke, Silverstein, Peter S., Periyasamy, Palsamy, Buch, Shilpa

“…•HIV-1 infection and drug abuse are intertwined epidemics.•Animal models are necessary to decipher the impact of drugs on HAND progression.•Non-human primates…”
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Human pegivirus RNA is found in multiple blood mononuclear cells in vivo and serum-derived viral RNA-containing particles are infectious in vitro by Chivero, Ernest T, Bhattarai, Nirjal, Rydze, Robert T, Winters, Mark A, Holodniy, Mark, Stapleton, Jack T

“…Human pegivirus (HPgV; previously called GB virus C/hepatitis G virus) has limited pathogenicity, despite causing persistent infection, and is associated with…”
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Protective Role of Lactobacillus rhamnosus Probiotic in Reversing Cocaine-Induced Oxidative Stress, Glial Activation and Locomotion in Mice by Chivero, Ernest T., Sil, Susmita, Singh, Seema, Thangaraj, Annadurai, Gordon, Lila, Evah-Nzoughe, Grace B., Ferguson, Natasha, Callen, Shannon, Buch, Shilpa

“…Cocaine abuse is known to cause inflammation, oxidative injury and alterations in the gut microbiota. Although emerging studies have demonstrated the role of…”
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NLRP3 Inflammasome Blockade Reduces Cocaine-Induced Microglial Activation and Neuroinflammation by Chivero, Ernest T., Thangaraj, Annadurai, Tripathi, Ashutosh, Periyasamy, Palsamy, Guo, Ming-Lei, Buch, Shilpa

“…Cocaine use disorder is a major health crisis that is associated with increased oxidative stress and neuroinflammation. While the role of NLRP3 inflammasome in…”
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Astrocytes & Astrocyte derived Extracellular Vesicles in Morphine Induced Amyloidopathy: Implications for Cognitive Deficits in Opiate Abusers by Sil, Susmita, Singh, Seema, Chemparathy, Divya T, Chivero, Ernest T, Gordon, Lila, Buch, Shilpa

“…While opiates like morphine play a major role in the pharmacotherapy for the control of pain associated with various diseases, paradoxically, their long-term…”
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