Search Results - "Chiu, Vi K."

Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells by Butler, Jason M, Chiu, Vi K, Benjamin, Laura, Rafii, Shahin, Bonner, Bryant, Nolan, Daniel J, Kobayashi, Mariko, Ding, Bi-Sen, O'Donnell, Rebekah, Shido, Koji, Kobayashi, Hideki

“…Endothelial cells form a vascular niche that supports haematopoietic stem cell function. Akt activation in endothelial cells upregulates angiocrine factors to…”
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Identification and characterization of RET fusions in advanced colorectal cancer by Le Rolle, Anne-France, Klempner, Samuel J, Garrett, Christopher R, Seery, Tara, Sanford, Eric M, Balasubramanian, Sohail, Ross, Jeffrey S, Stephens, Philip J, Miller, Vincent A, Ali, Siraj M, Chiu, Vi K

“…There is an unmet clinical need for molecularly directed therapies available for metastatic colorectal cancer. Comprehensive genomic profiling has the…”
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The prognostic significance of CXCL1 hypersecretion by human colorectal cancer epithelia and myofibroblasts by le Rolle, Anne-France, Chiu, Thang K, Fara, Michael, Shia, Jinru, Zeng, Zhaoshi, Weiser, Martin R, Paty, Philip B, Chiu, Vi K

“…Clinical therapy for metastatic colorectal cancer (CRC) remains limited, especially when the tumor harbors a KRAS mutation. This study aimed to identify…”
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Oncogenic KRAS activates an embryonic stem cell-like program in human colon cancer initiation by Le Rolle, Anne-France, Chiu, Thang K, Zeng, Zhaoshi, Shia, Jinru, Weiser, Martin R, Paty, Philip B, Chiu, Vi K

“…Colorectal cancer is the third most frequently diagnosed cancer worldwide. Prevention of colorectal cancer initiation represents the most effective overall…”
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Rural Disparities in Treatment-Related Financial Hardship and Adherence to Surveillance Colonoscopy in Diverse Colorectal Cancer Survivors by McDougall, Jean A, Banegas, Matthew P, Wiggins, Charles L, Chiu, Vi K, Rajput, Ashwani, Kinney, Anita Y

“…Cancer survivors increasingly report financial hardship as a consequence of the high cost of cancer care, yet the financial experience of rural cancer…”
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Mogamulizumab in Combination with Nivolumab in a Phase I/II Study of Patients with Locally Advanced or Metastatic Solid Tumors by Hong, David S, Rixe, Olivier, Chiu, Vi K, Forde, Patrick M, Dragovich, Tomislav, Lou, Yanyan, Nayak-Kapoor, Asha, Leidner, Rom, Atkins, James N, Collaku, Agron, Fox, Floyd E, Marshall, Margaret A, Olszanski, Anthony J

“…The aim of the study was to determine safety, antitumor activity, and pharmacodynamic profile of mogamulizumab, an anti-CCR4 monoclonal antibody targeting…”
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Pembrolizumab in Patients With Tumors With High Tumor Mutational Burden: Results From the Targeted Agent and Profiling Utilization Registry Study by Duvivier, Herbert L, Rothe, Michael, Mangat, Pam K, Garrett-Mayer, Elizabeth, Ahn, Eugene R, Al Baghdadi, Tareq, Alva, Ajjai S, Dublis, Stephanie A, Cannon, Timothy L, Calfa, Carmen J, Li, Rui, Behl, Deepti, Chiu, Vi K, Gold, Philip J, Marr, Alissa S, Mileham, Kathryn F, Powell, Steven Francis, Rodon, Jordi, Thota, Ramya, Grantham, Gina N, Gregory, Abigail, Hinshaw, Dominique C, Halabi, Susan, Schilsky, Richard L

“…The Targeted Agent and Profiling Utilization Registry (TAPUR) Study is a pragmatic basket trial evaluating antitumor activity of approved targeted agents in…”
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DKN-01 in Combination With Tislelizumab and Chemotherapy as First-Line Therapy in Advanced Gastric or Gastroesophageal Junction Adenocarcinoma: DisTinGuish by Klempner, Samuel J, Sonbol, Mohamad Bassam, Wainberg, Zev A, Uronis, Hope Elizabeth, Chiu, Vi K, Scott, Aaron James, Iqbal, Syma, Tejani, Mohamedtaki Abdulaziz, Chung, Vincent, Stilian, Melissa C, Thoma, Mathis, Zhang, Ying, Kagey, Michael H, Baum, Jason, Sirard, Cynthia A, Altura, Rachel A, Ajani, Jaffer A

“…The outcomes of anti-PD-1 agents plus fluoropyrimidine/platinum in frontline advanced gastroesophageal adenocarcinomas (aGEAs) remain poor. We investigated the…”
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Pertuzumab Plus Trastuzumab in Patients With Biliary Tract Cancer With ERBB2/3 Alterations: Results From the Targeted Agent and Profiling Utilization Registry Study by Cannon, Timothy L, Rothe, Michael, Mangat, Pam K, Garrett-Mayer, Elizabeth, Chiu, Vi K, Hwang, Jimmy, Vijayvergia, Namrata, Alese, Olatunji B, Dib, Elie G, Duvivier, Herbert L, Klute, Kelsey A, Sahai, Vaibhav, Ahn, Eugene R, Bedano, Pablo, Behl, Deepti, Sinclair, Sarah, Thota, Ramya, Urba, Walter J, Yang, Eddy S, Grantham, Gina N, Hinshaw, Dominique C, Gregory, Abigail, Halabi, Susan, Schilsky, Richard L

“…Targeted Agent and Profiling Utilization Registry is a phase II basket trial evaluating the antitumor activity of commercially available targeted agents in…”
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Socioeconomic disparities in health-related quality of life among colorectal cancer survivors by McDougall, Jean A., Blair, Cindy K., Wiggins, Charles L., Goodwin, Michael B., Chiu, Vi K., Rajput, Ashwani, Kinney, Anita Y.

“…Purpose Improvements in colorectal cancer (CRC) prevention, early detection, and treatment have resulted in substantial gains in survival. However, the…”
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Correlates of poor adherence to a healthy lifestyle among a diverse group of colorectal cancer survivors by Blair, Cindy K., McDougall, Jean A., Chiu, Vi K., Wiggins, Charles L., Rajput, Ashwani, Harding, Elizabeth M., Kinney, Anita Y.

“…Purpose Lifestyle factors may have a synergistic effect on health. We evaluated the correlates of poor adherence to a healthy lifestyle among a diverse sample…”
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Carboxyl Methylation of Ras Regulates Membrane Targeting and Effector Engagement by Chiu, Vi K., Silletti, Joseph, Dinsell, Victoria, Wiener, Heidi, Loukeris, Kristina, Ou, Guoming, Philips, Mark R., Pillinger, Michael H.

“…Post-translational modification of Ras proteins includes prenylcysteine-directed carboxyl methylation. Because Ras participates in Erk activation by epidermal…”
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Napabucasin Plus FOLFIRI in Patients With Previously Treated Metastatic Colorectal Cancer: Results From the Open-Label, Randomized Phase III CanStem303C Study by Shah, Manish A., Yoshino, Takayuki, Tebbutt, Niall C., Grothey, Axel, Tabernero, Josep, Xu, Rui-Hua, Cervantes, Andres, Oh, Sang Cheul, Yamaguchi, Kensei, Fakih, Marwan, Falcone, Alfredo, Wu, Christina, Chiu, Vi K., Tomasek, Jiri, Bendell, Johanna, Fontaine, Marilyn, Hitron, Matthew, Xu, Bo, Taieb, Julien, Van Cutsem, Eric

“…Napabucasin is an investigational, orally administered reactive oxygen species generator bioactivated by intracellular antioxidant NAD(P)H:quinone…”
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Site-Specific Genomic Alterations in a Well-Differentiated Pancreatic Neuroendocrine Tumor With High-Grade Progression by Martin, David R, LaBauve, Elisa, Pomo, Joseph M, Chiu, Vi K, Hanson, Joshua A, Gullapalli, Rama R

“…The major categories of pancreatic neuroendocrine tumor (PanNET) are well-differentiated NET and poorly differentiated neuroendocrine carcinoma. Sequencing of…”
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Ras signalling on the endoplasmic reticulum and the Golgi by Philips, Mark R, Chiu, Vi K, Bivona, Trever, Hach, Angela, Sajous, J. Bernard, Silletti, Joseph, Wiener, Heidi, Johnson, Ronald L, Cox, Adrienne D

“…Current models evoke the plasma membrane (PM) as the exclusive platform from which Ras regulates signalling. We developed a fluorescent probe that reports…”
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Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1 by Philips, Mark R, Bivona, Trever G, Pérez de Castro, Ignacio, Ahearn, Ian M, Grana, Theresa M, Chiu, Vi K, Lockyer, Peter J, Cullen, Peter J, Pellicer, Angel, Cox, Adrienne D

“…Ras proteins regulate cellular growth and differentiation, and are mutated in 30% of cancers. We have shown recently that Ras is activated on and transmits…”
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Colorectal Cancer Survivors’ Receptivity toward Genomic Testing and Targeted Use of Non-Steroidal Anti-Inflammatory Drugs to Prevent Cancer Recurrence by O’Malley, Denalee M., Blair, Cindy K., Greenbaum, Alissa, Wiggins, Charles L., Rajput, Ashwani, Chiu, Vi K., Kinney, Anita Y.

“…Genomic testing and targeted use of non-steroidal anti-inflammatory drugs (NSAIDs) may mitigate cancer recurrence risks. This study examines colorectal cancer…”
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Cancer comes of age embryonically by Chiu, Vi K, Le Rolle, Anne-France

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Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases by Michaelson, David, Ali, Wasif, Chiu, Vi K, Bergo, Martin, Silletti, Joseph, Wright, Latasha, Young, Stephen G, Philips, Mark

“…The CAAX motif at the C terminus of most monomeric GTPases is required for membrane targeting because it signals for a series of three posttranslational…”
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Nivolumab Plus Ipilimumab in Patients With Solid Tumors With ATM Mutations: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study by Rohatgi, Nitin, Rothe, Michael, Mangat, Pam K, Garrett-Mayer, Elizabeth, Meric-Bernstam, Funda, Pisick, Evan, Alese, Olatunji B, Reynolds, Christopher M, Thota, Ramya, Vaccaro, Gina M, von Mehren, Margaret, Arend, Rebecca C, Chiu, Vi K, Duvivier, Herbert L, Gold, Philip J, Hack, Keely, Marr, Alissa S, Winer, Arthur, Grantham, Gina N, Hinshaw, Dominique C, Gregory, Abigail, Halabi, Susan, Schilsky, Richard L

“…The Targeted Agent and Profiling Utilization Registry Study is a phase II basket study evaluating the antitumor activity of commercially available targeted…”
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