Search Results - "Chiu, Tim"

Akt and Rac1 signaling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance by Sylow, Lykke, Kleinert, Maximilian, Pehmøller, Christian, Prats, Clara, Chiu, Tim T., Klip, Amira, Richter, Erik A., Jensen, Thomas E.

“…Skeletal muscle plays a major role in regulating whole body glucose metabolism. Akt and Rac1 are important regulators of insulin-stimulated glucose uptake in…”
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Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells by Sun, Yi, Chiu, Tim T, Foley, Kevin P, Bilan, Philip J, Klip, Amira

“…Rab-GTPases are important molecular switches regulating intracellular vesicle traffic, and we recently showed that Rab8A and Rab13 are activated by insulin in…”
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Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle by Sylow, Lykke, Jensen, Thomas E, Kleinert, Maximilian, Mouatt, Joshua R, Maarbjerg, Stine J, Jeppesen, Jacob, Prats, Clara, Chiu, Tim T, Boguslavsky, Shlomit, Klip, Amira, Schjerling, Peter, Richter, Erik A

“…In skeletal muscle, the actin cytoskeleton-regulating GTPase, Rac1, is necessary for insulin-dependent GLUT4 translocation. Muscle contraction increases…”
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Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle by Chiu, Tim T., Jensen, Thomas E., Sylow, Lykke, Richter, Erik A., Klip, Amira

“…Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in…”
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Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells by Tunduguru, Ragadeepthi, Chiu, Tim T., Ramalingam, Latha, Elmendorf, Jeffrey S., Klip, Amira, Thurmond, Debbie C.

“…Insulin-stimulated PAK1 activation initiates F-actin remodeling by regulating the activity of cofilin and is required for mobilization of GLUT4 vesicles to the…”
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NOD2 Activation Induces Muscle Cell-Autonomous Innate Immune Responses and Insulin Resistance by Tamrakar, Akhilesh K, Schertzer, Jonathan D, Chiu, Tim T, Foley, Kevin P, Bilan, Philip J, Philpott, Dana J, Klip, Amira

“…Insulin resistance is associated with chronic low-grade inflammation in vivo, largely mediated by activated innate immune cells. Cytokines and pathogen-derived…”
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The Rho guanine dissociation inhibitor α inhibits skeletal muscle Rac1 activity and insulin action by Møller, Lisbeth L V, Ali, Mona S, Davey, Jonathan, Raun, Steffen H, Andersen, Nicoline R, Long, Jonathan Z, Qian, Hongwei, Jeppesen, Jacob F, Henriquez-Olguin, Carlos, Frank, Emma, Jensen, Thomas E, Højlund, Kurt, Wojtaszewski, Jørgen F P, Nielsen, Joachim, Chiu, Tim T, Jedrychowski, Mark P, Gregorevic, Paul, Klip, Amira, Richter, Erik A, Sylow, Lykke

“…The molecular events governing skeletal muscle glucose uptake have pharmacological potential for managing insulin resistance in conditions such as obesity,…”
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Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages by Pillon, Nicolas J, Arane, Karen, Bilan, Philip J, Chiu, Tim T, Klip, Amira

“…Obesity is associated with chronic low-grade inflammation. Within adipose tissue of mice fed a high fat diet, resident and infiltrating macrophages assume a…”
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Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation by Klip, Amira, Sun, Yi, Chiu, Tim Ting, Foley, Kevin P

“…Skeletal muscle is the major tissue disposing of dietary glucose, a function regulated by insulin-elicited signals that impart mobilization of GLUT4 glucose…”
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Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles by Boguslavsky, Shlomit, Chiu, Tim, Foley, Kevin P, Osorio-Fuentealba, Cesar, Antonescu, Costin N, Bayer, K Ulrich, Bilan, Philip J, Klip, Amira

“…GLUT4-containing vesicles cycle between the plasma membrane and intracellular compartments. Insulin promotes GLUT4 exocytosis by regulating GLUT4 vesicle…”
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Evaluation of Phosphatidylinositol-4-Kinase IIIα as a Hepatitis C Virus Drug Target by VAILLANCOURT, Frederic H, BRAULT, Martine, CHIU, Tim T, MAHROUCHE, Louiza, FAUCHER, Anne-Marie, CARTIER, Mireille, CORDINGLEY, Michael G, BETHELL, Richard C, HUIPING JIANG, WHITE, Peter W, KUKOLJ, George, PILOTE, Louise, UYTTERSPROT, Nathalie, GAILLARD, Elias T, STOTTZ, James H, KNIGHT, Brian L, PANTAGES, Lynn, MCFARIAND, Mary, BREITFELDER, Steffen

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells by Chiu, Tim Ting, Patel, Nish, Shaw, Alisa E, Bamburg, James R, Klip, Amira

“…GLUT4 vesicles are actively recruited to the muscle cell surface upon insulin stimulation. Key to this process is Rac-dependent reorganization of filamentous…”
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Influence of fin size and distribution on solid-liquid phase change in a rectangular enclosure by Biwole, Pascal Henry, Groulx, Dominic, Souayfane, Farah, Chiu, Tim

“…This paper details a numerical study of solid-liquid phase change heat transfer in a rectangular enclosure with the aim of optimizing the number, dimension,…”
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Rac-1 Superactivation Triggers Insulin-independent Glucose Transporter 4 (GLUT4) Translocation That Bypasses Signaling Defects Exerted by c-Jun N-terminal kinase (JNK)- and Ceramide-induced Insulin Resistance by Chiu, Tim Ting, Sun, Yi, Koshkina, Alexandra, Klip, Amira

“…Insulin activates a cascade of signaling molecules, including Rac-1, Akt, and AS160, to promote the net gain of glucose transporter 4 (GLUT4) at the plasma…”
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A Phase 1/2 first-in-human study to evaluate the safety, tolerability, and pharmacokinetics of UX053 in patients with glycogen storage disease type III by Rodriguez-Buritica, David F., Mozaffar, Tahseen, Comi, Giacomo P., Morales-Conejo, Montserrat, Phan, Han C., Rahman, Syeda, Luca, Diana, Chiu, Tim, Gupta, Manju, Hawtin, Rachael, Grimm, Andrew

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Structure-Activity Relationships and Discovery of (S)-6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6H-pyrido1,2-h1,7naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer by Gotchev, Dimitar, Dorsey, Bruce D, Nguyen, Duyan, Kakarla, Ramesh, Dugan, Benjamin, Chen, Shuai, Gao, Min, Bailey, Laurèn, Liu, Fei, Harasym, Troy, Chiu, Tim, Tang, Sunny, Lee, Amy C-H, Cole, Andrew G, Sofia, Michael J

“…Approved therapies for hepatitis B virus (HBV) treatment include nucleos(t)ides and interferon alpha (IFN-α) which effectively suppress viral replication, but…”
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Structure–Activity Relationships and Discovery of ( S )-5-( tert -Butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1,2,5,6-tetrahydropyrido[2′,1′:2,3]imidazo[4,5- h ]quinoline-3-carboxylic Acid (AB-161), a Novel Orally Available and Liver-Centric HBV RNA Destabilizer by Gotchev, Dimitar, Chen, Shuai, Dugan, Benjamin, Dorsey, Bruce D., Wang, Xu, Sheraz, Muhammad, Kowalski, Rose, Liu, Fei, Tang, Sunny, Chiu, Tim, Harasym, Troy, Graves, Ingrid E., Thi, Emily P., Mason, Jeremy D., Overholt, Nathan, Dugyala, Ravi, Lam, Angela M., Cole, Andrew G., Sofia, Michael J.

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Structure-Activity Relationships and Discovery of (S)-5-(tert-Butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1,2,5,6-tetrahydropyrido2',1':2,3imidazo4,5-hquinoline-3-carboxylic Acid (AB-161), a Novel Orally Available and Liver-Centric HBV RNA Destabilizer by Gotchev, Dimitar, Chen, Shuai, Dugan, Benjamin, Dorsey, Bruce D, Wang, Xu, Sheraz, Muhammad, Kowalski, Rose, Liu, Fei, Tang, Sunny, Chiu, Tim, Harasym, Troy, Graves, Ingrid E, Thi, Emily P, Mason, Jeremy D, Overholt, Nathan, Dugyala, Ravi, Lam, Angela M, Cole, Andrew G, Sofia, Michael J

“…Lowering hepatitis B surface antigen (HBsAg) levels from covalently closed circular DNA (cccDNA) and the integrated genome could reduce the persistence of…”
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Structure–Activity Relationships and Discovery of (S)‑6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro‑6H‑pyrido[1,2‑h][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer by Gotchev, Dimitar, Dorsey, Bruce D., Nguyen, Duyan, Kakarla, Ramesh, Dugan, Benjamin, Chen, Shuai, Gao, Min, Bailey, Laurèn, Liu, Fei, Harasym, Troy, Chiu, Tim, Tang, Sunny, Lee, Amy C.-H., Cole, Andrew G., Sofia, Michael J.

“…Approved therapies for hepatitis B virus (HBV) treatment include nucleos­(t)­ides and interferon alpha (IFN-α) which effectively suppress viral replication,…”
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Structure-Activity Relationships and Discovery of ( S )-6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6 H -pyrido[1,2- h ][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer by Gotchev, Dimitar, Dorsey, Bruce D, Nguyen, Duyan, Kakarla, Ramesh, Dugan, Benjamin, Chen, Shuai, Gao, Min, Bailey, Laurèn, Liu, Fei, Harasym, Troy, Chiu, Tim, Tang, Sunny, Lee, Amy C-H, Cole, Andrew G, Sofia, Michael J

“…Approved therapies for hepatitis B virus (HBV) treatment include nucleos(t)ides and interferon alpha (IFN-α) which effectively suppress viral replication, but…”
Get full text