Search Results - "Chiu, Cecilia P.C."

A phase 1 study to evaluate the safety and LDL cholesterol–lowering effects of RG7652, a fully human monoclonal antibody against proprotein convertase subtilisin/kexin type 9 by Baruch, Amos, Luca, Diana, Kahn, Robert S., Cowan, Kyra J., Leabman, Maya, Budha, Nageshwar R., Chiu, Cecilia P.C., Wu, Yan, Kirchhofer, Daniel, Peterson, Andrew, Davis Jr, John C., Tingley, Whittemore G.

“…Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) downregulates low‐density lipoprotein (LDL) receptors, thereby leading to a rise in…”
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Structure and Mechanism of the Lipooligosaccharide Sialyltransferase from Neisseria meningitidis by Lin, Leo Y.-C., Rakic, Bojana, Chiu, Cecilia P.C., Lameignere, Emilie, Wakarchuk, Warren W., Withers, Stephen G., Strynadka, Natalie C.J.

“…The first x-ray crystallographic structure of a CAZY family-52 glycosyltransferase, that of the membrane associated α2,3/α2,6 lipooligosaccharide…”
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High-Throughput Analyses of Therapeutic Antibodies Using High-Field Asymmetric Waveform Ion Mobility Spectrometry Combined with SampleStream and Intact Protein Mass Spectrometry by Shi, Rachel Liuqing, Dillon, Michael A, Compton, Philip D, Sawyer, William S, Thorup, John R, Kwong, Mandy, Chan, Pamela, Chiu, Cecilia P C, Li, Ran, Yadav, Rajbharan, Lee, Genee Y, Gober, Joshua G, Li, Zhiyu, ElSohly, Adel M, Ovacik, Ayse Meric, Koerber, James T, Spiess, Christoph, Josephs, Jonathan L, Tran, John C

“…Intact protein mass spectrometry (MS) coupled with liquid chromatography was applied to characterize the pharmacokinetics and stability profiles of therapeutic…”
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Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis by Chavarria-Smith, Joseph, Chiu, Cecilia P C, Jackman, Janet K, Yin, Jianping, Zhang, Juan, Hackney, Jason A, Lin, Wei-Yu, Tyagi, Tulika, Sun, Yonglian, Tao, Janet, Dunlap, Debra, Morton, William D, Ghodge, Swapnil V, Maun, Henry R, Li, Hong, Hernandez-Barry, Hilda, Loyet, Kelly M, Chen, Emily, Liu, John, Tam, Christine, Yaspan, Brian L, Cai, Hao, Balazs, Mercedesz, Arron, Joseph R, Li, Jing, Wittwer, Arthur J, Pappu, Rajita, Austin, Cary D, Lee, Wyne P, Lazarus, Robert A, Sudhamsu, Jawahar, Koerber, James T, Yi, Tangsheng

“…The epidermis is a barrier that prevents water loss while keeping harmful substances from penetrating the host. The impermeable cornified layer of the stratum…”
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Novel Anti-LY6G6D/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Colorectal Cancer by Wang, Peiyin, Sun, Liping L, Clark, Robyn, Hristopoulos, Maria, Chiu, Cecilia P C, Dillon, Michael, Lin, WeiYu, Lo, Amy A, Chalsani, Sreedevi, Das Thakur, Meghna, Zimmerman Savill, Kristin M, Rougé, Lionel, Lupardus, Patrick, Piskol, Robert, Husain, Bushra, Ellerman, Diego, Shivva, Vittal, Leong, Steven R, Ovacik, Meric, Totpal, Klara, Wu, Yan, Spiess, Christoph, Lee, Genee, Leipold, Douglas D, Polson, Andrew G

“…New therapeutics and combination regimens have led to marked clinical improvements for the treatment of a subset of colorectal cancer. Immune checkpoint…”
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Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma by Jackman, Janet K., Stockwell, Amy, Choy, David F., Xie, Markus M., Lu, Peipei, Jia, Guiquan, Li, Hong, Abbas, Alexander R., Bronson, Paola G., Lin, Wei-Yu, Chiu, Cecilia P.C., Maun, Henry R., Roose-Girma, Merone, Tam, Lucinda, Zhang, Juan, Modrusan, Zora, Graham, Robert R., Behrens, Timothy W., White, Steven R., Naureckas, Ted, Ober, Carole, Ferreira, Manuel, Sedlacek, Radislav, Wu, Jiansheng, Lee, Wyne P., Lazarus, Robert A., Koerber, James T., Arron, Joseph R., Yaspan, Brian L., Yi, Tangsheng

“…Clinical studies of type 2 (T2) cytokine-related neutralizing antibodies in asthma have identified a substantial subset of patients with low levels of T2…”
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High-throughput screening methodology for the directed evolution of glycosyltransferases by Withers, Stephen G, Aharoni, Amir, Thieme, Karena, Chiu, Cecilia P C, Buchini, Sabrina, Lairson, Luke L, Chen, Hongming, Strynadka, Natalie C J, Wakarchuk, Warren W

“…Engineering of glycosyltransferases (GTs) with desired substrate specificity for the synthesis of new oligosaccharides holds great potential for the…”
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Structural Analysis of the α-2,3-Sialyltransferase Cst-I from Campylobacter jejuni in Apo and Substrate-Analogue Bound Forms by Chiu, Cecilia P. C, Lairson, Luke L, Gilbert, Michel, Wakarchuk, Warren W, Withers, Stephen G, Strynadka, Natalie C. J

“…Sialic acid is an essential sugar in biology that plays key roles in numerous cellular processes and interactions. The biosynthesis of sialylated…”
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Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog by Strynadka, Natalie C J, Chiu, Cecilia P C, Watts, Andrew G, Lairson, Luke L, Gilbert, Michel, Lim, Daniel, Wakarchuk, Warren W, Withers, Stephen G

“…Sialic acid terminates oligosaccharide chains on mammalian and microbial cell surfaces, playing critical roles in recognition and adherence. The enzymes that…”
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Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue by Lairson, Luke L, Chiu, Cecilia P C, Ly, Hoa D, He, Shouming, Wakarchuk, Warren W, Strynadka, Natalie C J, Withers, Stephen G

“…Lipopolysaccharyl-alpha-1,4-galactosyltransferase C (LgtC), a glycosyltransferase family 8 alpha-1,4-galactosyltransferase from Neisseria meningitidis,…”
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