Search Results - "Chiu, Bo Chin"

Cutting edge: Central memory CD8 T cells in aged mice are virtual memory cells by Chiu, Bo-Chin, Martin, Brian E, Stolberg, Valerie R, Chensue, Stephen W

“…The number of memory phenotype CD8 T cells increases dramatically with aging in both humans and mice. However, the mechanism for this is unknown. The…”
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Cytokine-Chemokine Networks in Experimental Mycobacterial and Schistosomal Pulmonary Granuloma Formation by Chiu, Bo-Chin, Freeman, Christine M, Stolberg, Valerie R, Komuniecki, Eric, Lincoln, Pamela M, Kunkel, Steven L, Chensue, Stephen W

“…Type-1 and type-2 lung granulomas, respectively, elicited by bead immobilized Mycobacteria bovis and Schistosoma mansoni egg antigens (Ags) display different…”
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CCR4 Participation in Th Type 1 (Mycobacterial) and Th Type 2 (Schistosomal) Anamnestic Pulmonary Granulomatous Responses by Freeman, Christine M, Stolberg, Valerie R, Chiu, Bo-Chin, Lukacs, Nicholas W, Kunkel, Steven L, Chensue, Stephen W

“…CCR4 is purported to be a Th type 2 (Th2) cell-biased receptor but its functional role is unclear. Recent studies suggest that chemokine receptor expression…”
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Impaired Lung Dendritic Cell Activation in CCR2 Knockout Mice by Chiu, Bo-Chin, Freeman, Christine M., Stolberg, Valerie R., Hu, Jerry S., Zeibecoglou, Kyriaki, Lu, Bao, Gerard, Craig, Charo, Israel F., Lira, Sergio A., Chensue, Stephen W.

“…Dendritic cell (DC) recruitment is a hallmark event in antigen (Ag)-challenged lungs. We previously reported models for analyzing DC migration and activation…”
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The host environment is responsible for aging-related functional NK cell deficiency by Chiu, Bo-Chin, Martin, Brian E, Stolberg, Valerie R, Chensue, Stephen W

“…NK cells play an important role in immunity against infection and tumors. Aging-related functional NK cell deficiency is well documented in humans and mice…”
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Population analysis of CD4+ T cell chemokine receptor transcript expression during in vivo type-1 (mycobacterial) and type-2 (schistosomal) immune responses by Chiu, Bo‐Chin, Shang, Xiao‐Zhou, Stolberg, Valerie R., Komuniecki, Eric, Chensue, Stephen W.

“…Chemokine receptor transcripts were defined among CD4+ T cells in lymph nodes of mice with type‐1 and type‐2 inflammation, respectively, elicited by…”
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Chemokine responses in schistosomal antigen‐elicited granuloma formation by Chiu, Bo‐Chin, Chensue, Stephen W.

“…Summary Host immune systems have evolved specialized responses to multicellular parasites. This is well represented by the type 2 granulomatous response to…”
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Mononuclear phagocyte-derived IL-10 suppresses the innate IL-12/IFN-gamma axis in lung-challenged aged mice by Chiu, Bo-Chin, Stolberg, Valerie R, Chensue, Stephen W

“…Previously, we reported that IL-10-producing mononuclear phagocytes increase in lungs of aged mice, causing impaired innate cytokine expression. Since…”
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Increased Foxp3 + Treg cell activity reduces dendritic cell co-stimulatory molecule expression in aged mice by Chiu, Bo-Chin, Stolberg, Valerie R., Zhang, Haoming, Chensue, Stephen W.

“…As potent suppressors of immune responses to self- and foreign-antigens, Foxp3 + Treg cells are suspected to be involved in immunosuppression leading to…”
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CC Chemokine Receptor 4 Contributes to Innate NK and Chronic Stage T Helper Cell Recall Responses during Mycobacterium bovis Infection by Stolberg, Valerie R, Chiu, Bo-Chin, Schmidt, Brian M, Kunkel, Steven L, Sandor, Matyas, Chensue, Stephen W

“…Cysteine-cysteinyl chemokine receptor 4 (CCR4) is expressed by a variety of T-cell subsets and leukocytes. This study examined the participation of CCR4 in…”
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CCR8 Is Expressed by Antigen-Elicited, IL-10-Producing CD4+CD25+ T Cells, Which Regulate Th2-Mediated Granuloma Formation in Mice by Freeman, Christine M, Chiu, Bo-Chin, Stolberg, Valerie R, Hu, Jerry, Zeibecoglou, Kyriaki, Lukacs, Nicholas W, Lira, Sergio A, Kunkel, Steven L, Chensue, Stephen W

“…CCR8 was initially described as a Th2 cell-restricted receptor, but this has not been fully tested in vivo. The present study used ex vivo and in vivo…”
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Cysteine-Cysteinyl Chemokine Receptor 6 Mediates Invariant Natural Killer T Cell Airway Recruitment and Innate Stage Resistance during Mycobacterial Infection by Stolberg, Valerie R., Chiu, Bo-chin, Martin, Brian E., Shah, Samir A., Sandor, Matyas, Chensue, Stephen W.

“…This study examined the contribution of cysteine-cysteinyl chemokine receptor 6 (CCR6) to the innate pulmonary antimycobacterial immune response. Using a mouse…”
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The Innate Pulmonary Granuloma: Characterization and Demonstration of Dendritic Cell Recruitment and Function by Chiu, Bo-Chin, Freeman, Christine M, Stolberg, Valerie R, Hu, Jerry S, Komuniecki, Eric, Chensue, Stephen W

“…Granulomas are innate sequestration responses that can be modified by superimposed acquired immune mechanisms. The present study examined the innate stage of…”
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Eosinophil Recruitment in Type-2 Hypersensitivity Pulmonary Granulomas : Source and Contribution of Monocyte Chemotactic Protein-3 (CCL7) by Shang, Xiao-Zhou, Chiu, Bo-Chin, Stolberg, Valerie, Lukacs, Nicholas W, Kunkel, Steven L, Murphy, Hedwig S, Chensue, Stephen W

“…Monocyte chemotactic protein-3 (MCP-3/CCL7) has potent eosinophil chemoattractant properties. The present study determined its relative contribution to the…”
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Mononuclear Phagocyte-Derived Interleukin-10 Suppresses the Innate Pulmonary Granuloma Cytokine Response in Aged Mice by Chiu, Bo-Chin, Stolberg, Valerie R, Freeman, Christine M, Chensue, Stephen W

“…Granulomas are sequestration responses observed in a wide variety of clinical conditions, including mycobacterial infection. We previously reported impaired…”
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AMD3465, a Novel CXCR4 Receptor Antagonist, Abrogates Schistosomal Antigen-Elicited (Type-2) Pulmonary Granuloma Formation by Hu, Jerry S., Freeman, Christine M., Stolberg, Valerie R., Chiu, Bo Chin, Bridger, Gary J., Fricker, Simon P., Lukacs, Nicholas W., Chensue, Stephen W.

“…CXCR4 is a major receptor for CXCL12 and is known to participate in multiple physiological systems. The present study tested a second generation CXCR4…”
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Analysis of inducible costimulatory molecule participation during the induction and elicitation of granulomatous responses to mycobacterial and schistosomal antigens by Stolberg, Valerie R., Chiu, Bo-chin, Komuniecki, Eric, Freeman, Christine M., Chensue, Stephen W.

“…The contribution of inducible costimulatory molecule (ICOS) to Th1 and Th2 cell-mediated immune responses was examined in well-defined pathogen…”
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Central Memory CD8 T Cells in Aged Mice Are Virtual Memory Cells by Chiu, Bo-Chin, Martin, Brian E., Stolberg, Valerie R., Chensue, Stephen W.

“…The number of memory phenotype CD8 T cells increases dramatically with aging in both humans and mice. However, the mechanism for this is unknown. The…”
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Differential effects of ageing on cytokine and chemokine responses during type-1 (Mycobacterial) and type-2 (Schistosomal) pulmonary granulomatous inflammation in mice by Chiu, Bo Chin, Shang, Xiaozhou, Frait, Kirsten A, Hu, Jerry S, Komuniecki, Eric, Miller, Richard A, Chensue, Stephen W

“…Cytokine and chemokine responses during anamnestic type-1 and type-2 lung granuloma formation were evaluated in mice at 6, 12, 18 and 24-months of age. Lesions…”
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CC chemokine receptor 4 is required for optimal Th1 memory but not IL-17+ gamma/delta T cell effector responses during Mycobacterium bovis infection (96.5) by Chensue, Stephen W., Stolberg, Valerie R., Chiu, Bo-Chin, Schmidt, Brian M., Kunkel, Steven L., Sandor, Matyas

“…The CC chemokine receptor 4 (CCR4) is a widely expressed receptor that in regard to T cell biology was purported to be a Th2 restricted receptor, however…”
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