Search Results - "Chitturi, Trinadha Rao"
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Synthesis, preliminary biological evaluation and molecular modeling of some new heterocyclic inhibitors of TACE
Published in European journal of medicinal chemistry (01-11-2011)“…Central heteroaryl ring analogues belonging to a series of potent hydroxamate TACE inhibitors were synthesized. The TACE inhibitory activities of these…”
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Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel antihistamine SUN-1334H
Published in International archives of allergy and immunology (01-01-2010)“…The anti-inflammatory potential of antihistamines has significant clinical utility. Long-term pharmacotherapy of so-called 'safe' antihistamines may be…”
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In the Quest for Potent and Selective Malic Enzyme 3 Inhibitors for the Treatment of Pancreatic Ductal Adenocarcinoma
Published in ACS medicinal chemistry letters (12-01-2023)“…The genome of pancreatic ductal adenocarcinoma (PDAC) is associated with frequent deletion of the tumor suppressor gene SMAD family member 4 (SMAD4) with…”
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Preclinical Efficacy and Safety Pharmacology of SUN-1334H, a Potent Orally Active Antihistamine Agent
Published in Drugs in R&D (2008)“…Methods: In vitro antihistamine activity and selectivity of SUN-1334H was evaluated in a panel of receptor and enzyme assays and functional assays using…”
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