Search Results - "Chittezhath, Manesh"

Macrophage polarization and plasticity in health and disease by Biswas, Subhra K., Chittezhath, Manesh, Shalova, Irina N., Lim, Jyue-Yuan

“…The role of myelomonocytic cells like monocytes and macrophages as first line of host defense is well established. Recent understanding of these cells using…”
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Molecular Profiling Reveals a Tumor-Promoting Phenotype of Monocytes and Macrophages in Human Cancer Progression by Chittezhath, Manesh, Dhillon, Manprit Kaur, Lim, Jyue Yuan, Laoui, Damya, Shalova, Irina N., Teo, Yi Ling, Chen, Jinmiao, Kamaraj, Revathy, Raman, Lata, Lum, Josephine, Thamboo, Thomas Paulraj, Chiong, Edmund, Zolezzi, Francesca, Yang, Henry, Van Ginderachter, Jo A., Poidinger, Michael, Wong, Alvin S.C., Biswas, Subhra K.

“…Monocytes and macrophages are major components of the tumor microenvironment, but their contributions to human cancer are poorly understood. We used molecular…”
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Macrophage polarization to a unique phenotype driven by B cells by Wong, Siew-Cheng, Puaux, Anne-Laure, Chittezhath, Manesh, Shalova, Irina, Kajiji, Tasneem S, Wang, Xiaojie, Abastado, Jean-Pierre, Lam, Kong-Peng, Biswas, Subhra K

“…Regulation of adaptive immunity by innate immune cells is widely accepted. Conversely, adaptive immune cells can also regulate cells of the innate immune…”
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Effect of Silibinin on the Growth and Progression of Primary Lung Tumors in Mice by Singh, Rana P., Deep, Gagan, Chittezhath, Manesh, Kaur, Manjinder, Dwyer-Nield, Lori D., Malkinson, Alvin M., Agarwal, Rajesh

“…Background: Silibinin, a flavanone from milk thistle, inhibits the growth of tumors in several rodent models. We examined the effects of dietary silibinin on…”
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Silibinin inhibits cytokine-induced signaling cascades and down-regulates inducible nitric oxide synthase in human lung carcinoma A549 cells by Chittezhath, Manesh, Deep, Gagan, Singh, Rana P, Agarwal, Chapla, Agarwal, Rajesh

“…Recently, we reported that silibinin inhibits primary lung tumor growth and progression in mice and down-regulates inducible nitric oxide synthase (iNOS)…”
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Protumoral role of monocytes in human B-cell precursor acute lymphoblastic leukemia: involvement of the chemokine CXCL10 by Lee, Yunqin, Chittezhath, Manesh, André, Valentina, Zhao, Helen, Poidinger, Michael, Biondi, Andrea, D'Amico, Giovanna, Biswas, Subhra K.

“…Myelomonocytic cells play a key role in the progression of many solid tumors. However, very little is known about their contribution to the progression of…”
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The LIDPAD Mouse Model Captures the Multisystem Interactions and Extrahepatic Complications in MASLD by Low, Zun Siong, Chua, Damien, Cheng, Hong Sheng, Tee, Rachel, Tan, Wei Ren, Ball, Christopher, Sahib, Norliza Binte Esmail, Ng, Ser Sue, Qu, Jing, Liu, Yingzi, Hong, Haiyu, Cai, Chaonong, Rao, Nandini Chilagondanahalli Lakshmi, Wee, Aileen, Muthiah, Mark Dhinesh, Bichler, Zoë, Mickelson, Barbara, Kong, Mei Suen, Tay, Vanessa Shiyun, Yan, Zhuang, Chen, Jiapeng, Ng, Aik Seng, Yip, Yun Sheng, Vos, Marcus Ivan Gerard, Tan, Nicole Ashley, Lim, Dao Liang, Lim, Debbie Xiu En, Chittezhath, Manesh, Yaligar, Jadegoud, Verma, Sanjay Kumar, Poptani, Harish, Guan, Xue Li, Velan, Sambasivam Sendhil, Ali, Yusuf, Li, Liang, Tan, Nguan Soon, Wahli, Walter

“…Metabolic dysfunction‐associated steatotic liver disease (MASLD) represents an impending global health challenge. Current management strategies often face…”
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Human Monocytes Undergo Functional Re-programming during Sepsis Mediated by Hypoxia-Inducible Factor-1α by Shalova, Irina N., Lim, Jyue Yuan, Chittezhath, Manesh, Zinkernagel, Annelies S., Beasley, Federico, Hernández-Jiménez, Enrique, Toledano, Victor, Cubillos-Zapata, Carolina, Rapisarda, Annamaria, Chen, Jinmiao, Duan, Kaibo, Yang, Henry, Poidinger, Michael, Melillo, Giovanni, Nizet, Victor, Arnalich, Francisco, López-Collazo, Eduardo, Biswas, Subhra K.

“…Sepsis is characterized by a dysregulated inflammatory response to infection. Despite studies in mice, the cellular and molecular basis of human sepsis remains…”
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A cost-effective strategy for selection of third-party donors for a virus-specific T-cell bank for an Asian patient population by Linn, Yeh-ching, Sundar Raj, Kirubavathy, Teo, Bryan, Phang, Chew-Yen, Chittezhath, Manesh, Koh, Mickey

“…Third party virus-specific T cells (VST) has shown efficacy for opportunistic virus infection which do not have effective treatment or are drug-refractory. We…”
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Stage-specific inhibitory effects and associated mechanisms of silibinin on tumor progression and metastasis in transgenic adenocarcinoma of the mouse prostate model by Raina, Komal, Rajamanickam, Subapriya, Singh, Rana P, Deep, Gagan, Chittezhath, Manesh, Agarwal, Rajesh

“…Herein, using transgenic adenocarcinoma of the mouse prostate (TRAMP) model, we assessed the "stage-specific" efficacy of silibinin feeding against prostate…”
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TLR4 signals through islet macrophages to alter cytokine secretion during diabetes by Chittezhath, Manesh, Wai, Cho M M, Tay, Vanessa S Y, Chua, Minni, Langley, Sarah R, Ali, Yusuf

“…Toll-like receptors (TLRs), particularly TLR4, may act as immune sensors for metabolic stress signals such as lipids and link tissue metabolic changes to…”
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Islet macrophages are associated with islet vascular remodeling and compensatory hyperinsulinemia during diabetes by Chittezhath, Manesh, Gunaseelan, Divya, Zheng, Xiaofeng, Hasan, Riasat, Tay, Vanessa S Y, Lim, Seok Ting, Wang, Xiaomeng, Berggren, Per-Olof, Bornstein, Stefan, Boehm, Bernhard, Ruedl, Christiane, Ali, Yusuf

“…β-Cells respond to peripheral insulin resistance by first increasing circulating insulin during diabetes. Islet remodeling supports this compensation, but its…”
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The LIDPAD Mouse Model Captures the Multisystem Interactions and Extrahepatic Complications in MASLD (Adv. Sci. 35/2024) by Low, Zun Siong, Chua, Damien, Cheng, Hong Sheng, Tee, Rachel, Tan, Wei Ren, Ball, Christopher, Sahib, Norliza Binte Esmail, Ng, Ser Sue, Qu, Jing, Liu, Yingzi, Hong, Haiyu, Cai, Chaonong, Rao, Nandini Chilagondanahalli Lakshmi, Wee, Aileen, Muthiah, Mark Dhinesh, Bichler, Zoë, Mickelson, Barbara, Kong, Mei Suen, Tay, Vanessa Shiyun, Yan, Zhuang, Chen, Jiapeng, Ng, Aik Seng, Yip, Yun Sheng, Vos, Marcus Ivan Gerard, Tan, Nicole Ashley, Lim, Dao Liang, Lim, Debbie Xiu En, Chittezhath, Manesh, Yaligar, Jadegoud, Verma, Sanjay Kumar, Poptani, Harish, Guan, Xue Li, Velan, Sambasivam Sendhil, Ali, Yusuf, Li, Liang, Tan, Nguan Soon, Wahli, Walter

“…Metabolic Dysfunction‐Associated Steatotic Liver Disease The LIDPAD model, a single‐mouse metabolic dysfunction‐associated steatotic liver disease (MASLD)…”
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Radioprotective activity of naturally occurring organosulfur compounds by Chittezhath, Manesh, Kuttan, Girija

“…The radioprotective effects of naturally occurring sulfur compounds and isothiocyanates such as diallyl sulfide (DAS), diallyl disulfide (DADS), allyl methyl…”
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NR4A1 (Nur77) dependent monocytes patrol the lung vasculature and inhibit tumor cell invasion (P5068) by Hanna, Richard, Cekic, Cagler, Chittezhath, Manesh, Herrley, Erica, Chodaczek, Grzegorz, Biswas, Subhra, Hedrick, Catherine

“…Abstract The nuclear receptor NR4A1 (Nur77) is expressed in monocytes and macrophages, yet its function in regulating inflammation associated with cancer is…”
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Human Monocytes Undergo Functional Re-programming during Sepsis Mediated by Hypoxia-Inducible Factor-1[alpha] by Shalova, Irina N, Lim, Jyue Yuan, Chittezhath, Manesh, Zinkernagel, Annelies S, Beasley, Federico, Hernández-Jiménez, Enrique, Toledano, Victor, Cubillos-Zapata, Carolina, Rapisarda, Annamaria, Chen, Jinmiao, Duan, Kaibo, Yang, Henry, Poidinger, Michael, Melillo, Giovanni, Nizet, Victor, Arnalich, Francisco, López-Collazo, Eduardo, Biswas, Subhra K

“…Sepsis is characterized by a dysregulated inflammatory response to infection. Despite studies in mice, the cellular and molecular basis of human sepsis remains…”
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NF-κB pathway orchestrates the tumor promoting role of monocytes/macrophages in human renal cell carcinoma (66.45) by Chittezhath, Manesh, Dhillon, Manprit, Teo, YiLing, Chen, Jinmiao, Yang, Henry, Lum, Josephine, Shalova, Irina, Kamaraj, Revathy, Singh, Rajeev, Wong, Alvin, Biswas, Subhra

“…Abstract Growing evidences suggests that monocyte/macrophages play crucial role in cancer progression. Even though studies in transgenic mouse tumor models…”
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The proto-oncoprotein SYT (SS18) controls ATP release and regulates cyst formation by polarized MDCK cells by Chittezhath, Manesh, Frump, Andrea L., Jourquin, Jerome, Lobdell, Nichole, Eid, Josiane E.

“…The SYT proto-oncoprotein (also known as SS18) is a gene expression regulator conserved across species. Although its biological function is still unknown, the…”
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Stage Specific Inhibitory Effects and Associated Mechanisms of Silibinin on Tumor Progression and Metastasis in TRAMP Model by Raina, Komal, Rajamanickam, Subapriya, Singh, Rana P., Deep, Gagan, Chittezhath, Manesh, Agarwal, Rajesh

“…Herein, employing transgenic adenocarcinoma of the mouse prostate (TRAMP) model, we assessed the ‘stage specific’ efficacy of silibinin feeding against…”
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Silibinin inhibits cytokine-induced STATs, MAPKs, NF-κB and AP-1 activation, and down-regulates HIF-1α and iNOS in human lung carcinoma A549 cells by Chittezhath, Manesh, Deep, Gagan, Singh, Rana P., Agarwal, Chapla, Agarwal, Rajesh

“…Recently, we reported that silibinin inhibits primary lung tumor growth and progression in mice and down-regulates iNOS expression in tumors; however, the…”
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