Search Results - "Chitkara, Deepak"
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Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: Strategies and significance
Published in Journal of controlled release (10-10-2020)“…Exosomes are natural nanovesicles excreted by many cells for intercellular communication and for transfer of materials including proteins, nucleic acids and…”
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Exploration and insights into the cellular internalization and intracellular fate of amphiphilic polymeric nanocarriers
Published in Acta pharmaceutica Sinica. B (01-04-2021)“…The beneficial or deleterious effects of nanomedicines emerge from their complex interactions with intracellular pathways and their subcellular fate. Moreover,…”
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Lipid-polymer hybrid nanocarriers for delivering cancer therapeutics
Published in Journal of controlled release (10-02-2018)“…Cancer remained a major cause of death providing diversified challenges in terms of treatment including non-specific toxicity, chemoresistance and relapse…”
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Efficacy of gemcitabine conjugated and miRNA-205 complexed micelles for treatment of advanced pancreatic cancer
Published in Biomaterials (01-08-2014)“…Abstract Clinical effectiveness of gemcitabine in pancreatic cancer is hindered due to its rapid plasma metabolism and development of chemo-resistance. We have…”
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Exosomal fragment enclosed polyamine-salt nano-complex for co-delivery of docetaxel and mir-34a exhibits higher cytotoxicity and apoptosis in breast cancer cells
Published in Scientific reports (17-09-2024)“…A novel core–shell nanocarrier system has been designed for co-delivery of a small anticancer drug, docetaxel (DTX) and tumor suppressor (TS) miR-34a named as…”
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Self-Assembled Lecithin-Chitosan Nanoparticles Improved Rotigotine Nose-to-Brain Delivery and Brain Targeting Efficiency
Published in Pharmaceutics (01-03-2023)“…Rotigotine (RTG) is a non-ergoline dopamine agonist and an approved drug for treating Parkinson's disease. However, its clinical use is limited due to various…”
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Oral sorafenib-loaded microemulsion for breast cancer: evidences from the in-vitro evaluations and pharmacokinetic studies
Published in Scientific reports (12-08-2022)“…Sorafenib tosylate (SFB) is a multikinase inhibitor that inhibits tumour growth and proliferation for the management of breast cancer but is also associated…”
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Self-Assembling, Amphiphilic Polymer–Gemcitabine Conjugate Shows Enhanced Antitumor Efficacy Against Human Pancreatic Adenocarcinoma
Published in Bioconjugate chemistry (17-07-2013)“…The therapeutic efficacy of gemcitabine is severely compromised due to its rapid plasma metabolism. Moreover, its hydrophilicity poses a challenge for its…”
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Bile-Acid-Appended Triazolyl Aryl Ketones: Design, Synthesis, In Vitro Anticancer Activity and Pharmacokinetics in Rats
Published in Molecules (Basel, Switzerland) (22-09-2021)“…A library of bile-acid-appended triazolyl aryl ketones was synthesized and characterized by detailed spectroscopic techniques such as 1H and 13C NMR, HRMS and…”
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Delivery of Docetaxel to Brain Employing Piperine-Tagged PLGA-Aspartic Acid Polymeric Micelles: Improved Cytotoxic and Pharmacokinetic Profiles
Published in AAPS PharmSciTech (14-06-2019)“…In this study, poly-(lactic-co-glycolic) acid (PLGA) was conjugated with aspartic acid and was characterized by nuclear magnetic resonance and Fourier…”
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Chemoresistance in prostate cancer cells is regulated by miRNAs and Hedgehog pathway
Published in PloS one (29-06-2012)“…Many prostate cancers relapse due to the generation of chemoresistance rendering first-line treatment drugs like paclitaxel (PTX) ineffective. The present…”
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miRNA profiling in pancreatic cancer and restoration of chemosensitivity
Published in Cancer letters (01-07-2013)“…Abstract Pancreatic cancers relapse due to small but distinct population of cancer stem cells (CSCs) which are in turn regulated by miRNAs. The present study…”
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Enhanced tumor cell killing by ultrasound after microtubule depolymerization
Published in Bioengineering & translational medicine (01-09-2021)“…Recent studies show that tumor cells are vulnerable to mechanical stresses and undergo calcium‐dependent apoptosis (mechanoptosis) with mechanical perturbation…”
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Delivery strategies for CRISPR/Cas genome editing tool for retinal dystrophies: challenges and opportunities
Published in Asian journal of pharmceutical sciences (01-03-2022)“…CRISPR/Cas, an adaptive immune system in bacteria, has been adopted as an efficient and precise tool for site-specific gene editing with potential therapeutic…”
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Micellar Delivery of Cyclopamine and Gefitinib for Treating Pancreatic Cancer
Published in Molecular pharmaceutics (06-08-2012)“…Hedgehog (Hh) and epidermal growth factor receptor (EGFR) signaling are involved in pancreatic cancer progression. Targeting these pathways simultaneously with…”
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HPLC method for the determination of carboplatin and paclitaxel with cremophorEL in an amphiphilic polymer matrix
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15-08-2007)“…Simple and rapid reversed phase HPLC methods for individual as well as simultaneous analysis of paclitaxel and carboplatin with cremophorEL (CrEL) in an…”
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Proteostasis defects: Medicinal challenges of imperfect aging & neurodegeneration
Published in Translational medicine of aging (2023)“…A prolonged healthy life is based on the optimal activity of an organism’s organ systems, and healthy cells are at the core of this proper functioning…”
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BSA-PLGA-Based Core-Shell Nanoparticles as Carrier System for Water-Soluble Drugs
Published in Pharmaceutical research (01-09-2013)“…ABSTRACT Purpose Preparation, optimization and in vitro evaluation of core-shell nanoparticles comprising of a hydrophilic core of BSA surrounded by a…”
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CRISPR/Cas System for Genome Editing: Progress and Prospects as a Therapeutic Tool
Published in The Journal of pharmacology and experimental therapeutics (01-09-2019)“…CRISPR was first observed in 1987 in bacteria and archaea and was later confirmed as part of bacterial adaptive immunity against the attacking phage. The…”
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CRISPR/Cas mediated epigenome editing for cancer therapy
Published in Seminars in cancer biology (01-08-2022)“…The understanding of the relationship between epigenetic alterations, their effects on gene expression and the knowledge that these epigenetic alterations are…”
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